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Most deep neural networks use simple, fixed activation functions, such as sigmoids or rectified linear units, regardless of domain or network structure. We introduce differential equation units (DEUs), an improvement to modern neural…

Machine Learning · Computer Science 2019-05-21 MohamadAli Torkamani , Phillip Wallis , Shiv Shankar , Amirmohammad Rooshenas

Neural ordinary differential equations (ODEs) have been attracting increasing attention in various research domains recently. There have been some works studying optimization issues and approximation capabilities of neural ODEs, but their…

Machine Learning · Computer Science 2022-03-04 Hanshu Yan , Jiawei Du , Vincent Y. F. Tan , Jiashi Feng

A key appeal of the recently proposed Neural Ordinary Differential Equation (ODE) framework is that it seems to provide a continuous-time extension of discrete residual neural networks. As we show herein, though, trained Neural ODE models…

Machine Learning · Computer Science 2023-09-12 Katharina Ott , Prateek Katiyar , Philipp Hennig , Michael Tiemann

Optimal control problems with nonsmooth objectives and nonlinear partial differential equation (PDE) constraints are challenging, mainly because of the underlying nonsmooth and nonconvex structures and the demanding computational cost for…

Optimization and Control · Mathematics 2025-04-25 Yongcun Song , Xiaoming Yuan , Hangrui Yue , Tianyou Zeng

Deep neural networks (DNNs) are vulnerable to small adversarial perturbations of the inputs, posing a significant challenge to their reliability and robustness. Empirical methods such as adversarial training can defend against particular…

Machine Learning · Computer Science 2026-03-10 Kuo Gai , Sicong Wang , Shihua Zhang

Identifying dynamical systems from experimental data is a notably difficult task. Prior knowledge generally helps, but the extent of this knowledge varies with the application, and customized models are often needed. Neural ordinary…

Systems and Control · Electrical Eng. & Systems 2023-01-13 Mona Buisson-Fenet , Valery Morgenthaler , Sebastian Trimpe , Florent Di Meglio

Objective. Precise control of neural systems is essential to experimental investigations of how the brain controls behavior and holds the potential for therapeutic manipulations to correct aberrant network states. Model predictive control,…

Neurons and Cognition · Quantitative Biology 2024-08-06 Christof Fehrman , C. Daniel Meliza

An extensive body of empirical research has revealed remarkable regularities in the acquisition, organization, deployment, and neural representation of human semantic knowledge, thereby raising a fundamental conceptual question: what are…

Machine Learning · Computer Science 2022-10-12 Andrew M. Saxe , James L. McClelland , Surya Ganguli

Automated medical image segmentation plays a key role in quantitative research and diagnostics. Convolutional neural networks based on the U-Net architecture are the state-of-the-art. A key disadvantage is the hard-coding of the receptive…

Image and Video Processing · Electrical Eng. & Systems 2019-10-24 Hans Pinckaers , Geert Litjens

Neural networks can be fragile to input noise and adversarial attacks. In this work, we consider Convolutional Neural Ordinary Differential Equations (NODEs), a family of continuous-depth neural networks represented by dynamical systems,…

Machine Learning · Computer Science 2025-08-18 Muhammad Zakwan , Liang Xu , Giancarlo Ferrari-Trecate

The uncertainty in human driving behaviors leads to stop-and-go instabilities in freeway traffic. The traffic dynamics are typically modeled by the Aw-Rascle-Zhang (ARZ) Partial Differential Equation (PDE) models, in which the relaxation…

Optimization and Control · Mathematics 2025-09-29 Kaijing Lyu , Junmin Wang , Yihuai Zhang , Huan Yu

OD matrix estimation is a critical problem in the transportation domain. The principle method uses the traffic sensor measured information such as traffic counts to estimate the traffic demand represented by the OD matrix. The problem is…

Machine Learning · Computer Science 2023-07-13 Zheli Xiong , Defu Lian , Enhong Chen , Gang Chen , Xiaomin Cheng

Scientific machine learning is an emerging field that broadly describes the combination of scientific computing and machine learning to address challenges in science and engineering. Within the context of differential equations, this has…

Machine Learning · Computer Science 2026-04-03 Laurens R. Lueg , Victor Alves , Daniel Schicksnus , John R. Kitchin , Carl D. Laird , Lorenz T. Biegler

Deep learning has arguably achieved tremendous success in recent years. In simple words, deep learning uses the composition of many nonlinear functions to model the complex dependency between input features and labels. While neural networks…

Machine Learning · Statistics 2019-04-16 Jianqing Fan , Cong Ma , Yiqiao Zhong

While tumor dynamic modeling has been widely applied to support the development of oncology drugs, there remains a need to increase predictivity, enable personalized therapy, and improve decision-making. We propose the use of Tumor Dynamic…

Quantitative Methods · Quantitative Biology 2023-10-24 Mark Laurie , James Lu

We investigate the expressive power of deep residual neural networks idealized as continuous dynamical systems through control theory. Specifically, we consider two properties that arise from supervised learning, namely universal…

Machine Learning · Computer Science 2023-09-13 Jingpu Cheng , Qianxiao Li , Ting Lin , Zuowei Shen

Recently, domain-uniform stabilizability and detectability has been the central assumption %in order robustness results on the to ensure robustness in the sense of exponential decay of spatially localized perturbations in optimally…

Optimization and Control · Mathematics 2025-02-18 Benedikt Oppeneiger , Manuel Schaller , Karl Worthmann

Recent research in deep learning has shown that neural networks can learn differential equations governing dynamical systems. In this paper, we adapt this concept to Virtual Analog (VA) modeling to learn the ordinary differential equations…

Audio and Speech Processing · Electrical Eng. & Systems 2022-08-09 Jan Wilczek , Alec Wright , Vesa Välimäki , Emanuël Habets

Physics-Informed Neural Networks (PINNs) and Neural Ordinary Differential Equations (NODEs) represent two distinct machine learning frameworks for modeling nonlinear neuronal dynamics. This study systematically evaluates their performance…

Dynamical Systems · Mathematics 2026-03-31 Nikolaos M. Matzakos , Chrisovalantis Sfyrakis

We propose a reduced-order modeling approach for nonlinear, parameter-dependent ordinary differential equations (ODE). Dimensionality reduction is achieved using nonlinear maps represented by autoencoders. The resulting low-dimensional ODE…

Numerical Analysis · Mathematics 2026-04-16 Enrico Ballini , Marco Gambarini , Alessio Fumagalli , Luca Formaggia , Anna Scotti , Paolo Zunino