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How to allocate vaccines over heterogeneous individuals is one of the important policy decisions in pandemic times. This paper develops a procedure to estimate an individualized vaccine allocation policy under limited supply, exploiting…

Econometrics · Economics 2021-10-25 Toru Kitagawa , Guanyi Wang

During the COVID-19 pandemic, many organizations (e.g. businesses, companies, government facilities, etc.) have attempted to reduce infection risk by employing partial home office strategies. However, working from home can also reduce…

Data Structures and Algorithms · Computer Science 2022-04-05 Mansoor Davoodi , Abhishek Senapati , Adam Mertel , Weronika Schlechte-Welnicz , Justin M. Calabrese

We study an optimal control problem where the objective is to find the best vaccine allocation during an epidemic outbreak. The epidemic dynamics is described by an age-structured SIR model with nonlocal interactions. Both the infection and…

Optimization and Control · Mathematics 2026-05-19 Luís Almeida , Romain Ducasse , Elisa Paparelli

With the approval of vaccines for the coronavirus disease by many countries worldwide, most developed nations have begun, and developing nations are gearing up for the vaccination process. This has created an urgent need to provide a…

Computers and Society · Computer Science 2021-02-09 Mahzabeen Emu , Dhivya Chandrasekaran , Vijay Mago , Salimur Choudhury

We examine here the effects of recurrent vaccination and waning immunity on the establishment of an endemic equilibrium in a population. An individual-based model that incorporates memory effects for transmission rate during infection and…

Populations and Evolution · Quantitative Biology 2024-11-22 Félix Foutel-Rodier , Arthur Charpentier , Hélène Guérin

Epidemic risk assessment poses inherent challenges, with traditional approaches often failing to balance health outcomes and economic constraints. This paper presents a data-driven decision support tool that models epidemiological dynamics…

Applications · Statistics 2025-11-24 Chang Zhai , Ping Chen , Zhuo Jin , David Pitt

Real-time vaccination following an outbreak can effectively mitigate the damage caused by an infectious disease. However, in many cases, available resources are insufficient to vaccinate the entire at-risk population, logistics result in…

Populations and Evolution · Quantitative Biology 2016-03-29 Chantal Nguyen , Jean M. Carlson

The COVID-19 pandemic showed that stocking and procuring vaccines are different from the inventory holding problems of production. The safety of the supply is more important than cost minimization. The Hungarian inventory model is applied…

Computational Engineering, Finance, and Science · Computer Science 2024-10-28 Aysun Pınarbaşı , Béla Vizvári

In a world being hit by waves of COVID-19, vaccination is a light on the horizon. However, the roll-out of vaccination strategies and their influence on the pandemic are still open problems. In order to compare the effect of various…

Physics and Society · Physics 2021-04-23 N. L. Barreiro , C. I. Ventura , T. Govezensky , M. Núñez , P. G. Bolcatto , R. A. Barrio

In this paper, we present a decision support framework for optimizing multiple aspects of vaccine distribution across a multitier cold chain network. We propose two multi-period optimization formulations within this framework: first to…

Physics and Society · Physics 2022-01-12 Shanmukhi Sripada , Ayush Jain , Prasanna Ramamoorthy , Varun Ramamohan

We develop a model of infection spread that takes into account the existence of a vulnerable group as well as the variability of the social relations of individuals. We develop a compartmentalized power-law model, with power-law connections…

Physics and Society · Physics 2020-10-13 Simone Santini

The pandemic caused by the SARS-CoV-2 virus has exposed many flaws in the decision-making strategies used to distribute resources to combat global health crises. In this paper, we leverage reinforcement learning and optimization to improve…

Artificial Intelligence · Computer Science 2021-01-06 Lawrence Thul , Warren Powell

The COVID-19 vaccine development, manufacturing, transportation, and administration proved an extreme logistics operation of global magnitude. Global vaccination levels, however, remain a key concern in preventing the emergence of new…

General Economics · Economics 2025-01-10 Sharika J. Hegde , Max T. M. Ng , Marcos Rios , Hani S. Mahmassani , Ying Chen , Karen Smilowitz

The aftermath of the Covid-19 pandemic saw more severe outcomes for racial minority groups and economically-deprived communities. Such disparities can be explained by several factors, including unequal access to healthcare, as well as the…

Computers and Society · Computer Science 2024-03-12 Nicola Neophytou , Afaf Taïk , Golnoosh Farnadi

Vaccination has been proven to be the most effective method to prevent infectious diseases. However, in many low and middle-income countries with geographically dispersed and nomadic populations, last-mile vaccine delivery can be extremely…

Applications · Statistics 2021-04-30 Yuwen Yang , Jayant Rajgopal

Fairness in vaccination is not only important from a social justice point of view, but experience has shown that a fair distribution of vaccine proves more effective in public immunization by preventing highly-concentrated infected areas to…

Optimization and Control · Mathematics 2021-11-11 Mohammad Firouz , Linda Li , Daizy Ahmed , Abdulaziz Ahmed

In this paper, we propose a two-group SIR epidemic model to simulate the outcome of stay-at-home policy and wearing face masks during the first COVID-19 epidemic wave in the United States. Based on our proposed model, we further use the…

Populations and Evolution · Quantitative Biology 2021-01-11 Jun Liu , Xiang-Sheng Wang

During various stages of the COVID-19 pandemic, countries implemented diverse vaccine management approaches, influenced by variations in infrastructure and socio-economic conditions. This article provides a comprehensive overview of…

Optimization and Control · Mathematics 2024-05-27 Shibshankar Dey , Ali Kaan Kurbanzade , Esma S. Gel , Joseph Mihaljevic , Sanjay Mehrotra

Vaccines play a crucial role in the prevention and control of infectious diseases. However, the vaccine supply chain faces numerous challenges that hinder its efficiency. To address these challenges and enhance public health outcomes, many…

Theoretical Economics · Economics 2025-10-07 Ran Gu , Enhui Ding , Shigui Ma

The sudden and rapid spread of the COVID_19 pandemic with its terrible consequences has put the management of governments and the various world institutions into a crisis. They have been subjected to a considerable economic effort to be…

Optimization and Control · Mathematics 2024-01-08 Rehana Naz , Andrew Omame , Mariano Torrisi