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Cryo-electron microscopy (cryo-EM), the subject of the 2017 Nobel Prize in Chemistry, is a technology for determining the 3-D structure of macromolecules from many noisy 2-D projections of instances of these macromolecules, whose…

Computer Vision and Pattern Recognition · Computer Science 2020-04-22 Roy R. Lederman , Joakim Andén , Amit Singer

Semi-supervised learning (SSL) can reduce the need for large labelled datasets by incorporating unlabelled data into the training. This is particularly interesting for semantic segmentation, where labelling data is very costly and…

Computer Vision and Pattern Recognition · Computer Science 2022-10-20 Sebastian Scherer , Robin Schön , Rainer Lienhart

In single-particle cryo-electron microscopy (cryo-EM), the efficient determination of orientation parameters for 2D projection images poses a significant challenge yet is crucial for reconstructing 3D structures. This task is complicated by…

Image and Video Processing · Electrical Eng. & Systems 2025-09-30 Szu-Chi Chung

Weakly-supervised medical image segmentation is a challenging task that aims to reduce the annotation cost while keep the segmentation performance. In this paper, we present a novel framework, SimTxtSeg, that leverages simple text cues to…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Yuxin Xie , Tao Zhou , Yi Zhou , Geng Chen

Accurate and efficient catheter segmentation in 3D ultrasound (US) is essential for cardiac intervention. Currently, the state-of-the-art segmentation algorithms are based on convolutional neural networks (CNNs), which achieved remarkable…

Computer Vision and Pattern Recognition · Computer Science 2022-02-01 Hongxu Yang , Caifeng Shan , Alexander F. Kolen , Peter H. N. de With

X-ray computed tomography (CT) is a widely used imaging technique that provides detailed examinations into the internal structure of an object with synchrotron CT (SR-CT) enabling improved data quality by using higher energy, monochromatic…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Austin Yunker , Peter Kenesei , Hemant Sharma , Jun-Sang Park , Antonino Miceli , Rajkumar Kettimuthu

In this paper we study the formal algebraic structure underlying the intrinsic classification algorithm, recently introduced by Hadani, Shkolnisky, Singer and Zhao, for classifying noisy projection images of similar viewing directions in…

Representation Theory · Mathematics 2011-04-07 Ronny Hadani , Amit Singer

Accurate analysis and modeling of renal functions require a precise segmentation of the renal blood vessels. Micro-CT scans provide image data at higher resolutions, making more small vessels near the renal cortex visible. Although…

Image and Video Processing · Electrical Eng. & Systems 2023-05-29 Peidi Xu , Olga Sosnovtseva , Charlotte Mehlin Sørensen , Kenny Erleben , Sune Darkner

Annotation is a major hurdle in the semantic segmentation of microscopy images and volumes due to its prerequisite expertise and effort. This work enables the training of semantic segmentation networks on images with only a single point for…

Computer Vision and Pattern Recognition · Computer Science 2021-03-22 Shijie Li , Neel Dey , Katharina Bermond , Leon von der Emde , Christine A. Curcio , Thomas Ach , Guido Gerig

This paper addresses semi-supervised semantic segmentation by exploiting a small set of images with pixel-level annotations (strong supervisions) and a large set of images with only image-level annotations (weak supervisions). Most existing…

Computer Vision and Pattern Recognition · Computer Science 2022-01-12 Rumeng Yi , Yaping Huang , Qingji Guan , Mengyang Pu , Runsheng Zhang

There are many approaches to weakly-supervised training of networks to segment 2D images. By contrast, existing approaches to segmenting volumetric images rely on full-supervision of a subset of 2D slices of the 3D volume. We propose an…

Computer Vision and Pattern Recognition · Computer Science 2022-06-06 Udaranga Wickramasinghe , Patrick M. Jensen , Mian Shah , Jiancheng Yang , Pascal Fua

Cryogenic electron microscopy (cryo-EM) has become an enabling technology in drug discovery and in understanding molecular bases of disease by producing near-atomic resolution (less than 0.4 nm) 3D reconstructions of biological…

Computer Vision and Pattern Recognition · Computer Science 2020-07-23 Hong Xu , David E. Timm , Shireen Y. Elhabian

Cryo-electron microscopy (cryo-EM) has achieved near-atomic level resolution of biomolecules by reconstructing 2D micrographs. However, the resolution and accuracy of the reconstructed particles are significantly reduced due to the…

Computer Vision and Pattern Recognition · Computer Science 2024-01-03 Jing Zhang , Tengfei Zhao , ShiYu Hu , Xin Zhao

A single-particle cryo-electron microscopy (cryo-EM) measurement, called a micrograph, consists of multiple two-dimensional tomographic projections of a three-dimensional (3-D) molecular structure at unknown locations, taken under unknown…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Shay Kreymer , Amit Singer , Tamir Bendory

Cryo-electron microscopy (cryo-EM) has become a tool of fundamental importance in structural biology, helping us understand the basic building blocks of life. The algorithmic challenge of cryo-EM is to jointly estimate the unknown 3D poses…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Axel Levy , Frédéric Poitevin , Julien Martel , Youssef Nashed , Ariana Peck , Nina Miolane , Daniel Ratner , Mike Dunne , Gordon Wetzstein

Cryo-electron microscopy (cryo-EM) emerges as a pivotal technology for determining the architecture of cells, viruses, and protein assemblies at near-atomic resolution. Traditional particle picking, a key step in cryo-EM, struggles with…

Biomolecules · Quantitative Biology 2024-04-17 Chentianye Xu , Xueying Zhan , Min Xu

Noise and artifacts during computed tomography (CT) scans are a fundamental challenge affecting disease diagnosis. However, current methods either involve excessively long reconstruction times or rely on data-driven models for optimization,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Guoquan Wei , Liu Shi , Shaoyu Wang , Mohan Li , Cunfeng Wei , Qiegen Liu

The Audio-Visual Video Parsing task aims to identify and temporally localize the events that occur in either or both the audio and visual streams of audible videos. It often performs in a weakly-supervised manner, where only video event…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Jinxing Zhou , Dan Guo , Yiran Zhong , Meng Wang

Semi-supervised learning (SSL) has emerged as a promising paradigm for breast ultrasound (BUS) image segmentation, but it often suffers from unstable pseudo labels under extremely limited annotations, leading to inaccurate supervision and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Ruili Li , Jiayi Ding , Ruiyu Li , Yilun Jin , Shiwen Ge , Yuwen Zeng , Xiaoyong Zhang , Eichi Takaya , Jan Vrba , Noriyasu Homma

Despite the remarkable performance of supervised medical image segmentation models, relying on a large amount of labeled data is impractical in real-world situations. Semi-supervised learning approaches aim to alleviate this challenge using…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Yunyao Lu , Yihang Wu , Ahmad Chaddad , Tareef Daqqaq , Reem Kateb