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This mini review focuses on conductance measurements through molecular junctions containing few tens of molecules, which are fabricated along two approaches: (i) conducting atomic force microscope contacting a self-assembled monolayers on…

Applied Physics · Physics 2019-11-12 Dominique Vuillaume

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer, monitoring treatment and detecting…

Precise manipulation of single molecules has already led to remarkable insights in physics, chemistry, biology and medicine. However, widespread adoption of single-molecule techniques has been impeded by equipment cost and the laborious…

Biological Physics · Physics 2015-05-14 Ken Halvorsen , Wesley P. Wong

Quantum-logic techniques used to manipulate quantum systems are now increasingly being applied to molecules. Previous experiments on single trapped diatomic species have enabled state detection with excellent fidelities and highly precise…

Quantum Physics · Physics 2025-03-18 Kaveh Najafian , Ziv Meir , Mudit Sinhal , Stefan Willitsch

The operation of solid-state qubits often relies on single-shot readout using a nanoelectronic charge sensor, and the detection of events in a noisy sensor signal is crucial for high fidelity readout of such qubits. The most common…

Mesoscale and Nanoscale Physics · Physics 2015-06-09 J. R. Prance , B. J. Van Bael , C. B. Simmons , D. E. Savage , M. G. Lagally , Mark Friesen , S. N. Coppersmith , M. A. Eriksson

Nanopore based sequencing has demonstrated significant potential for the development of fast, accurate, and cost-efficient fingerprinting techniques for next generation molecular detection and sequencing. We propose a specific multi-layered…

Mesoscale and Nanoscale Physics · Physics 2014-05-15 Towfiq Ahmed , Jason T. Haraldsen , John J. Rehr , Massimiliano Di Ventra , Ivan K. Schuller , Alexander V. Balatsky

Electrochemical phenomena in biology often unfold in confined geometries where micrometer- to millimeter-scale domains coexist with nanometer-scale interfacial diffuse charge layers. We analyze a model lipid membrane-electrolyte system…

Soft Condensed Matter · Physics 2025-08-20 Joshua B. Fernandes , Hyeongjoo Row , Kranthi K. Mandadapu , Karthik Shekhar

Significant effort has been devoted to searching for new fundamental forces of nature. At short length scales (below approximately 10 nm), the strongest experimental constraints come from neutron scattering from individual nuclei in gases.…

High Energy Physics - Phenomenology · Physics 2023-09-11 Zachary Bogorad , Peter W. Graham , Giorgio Gratta

Single molecules are nanoscale thermodynamic systems with few degrees of freedom. Thus, the knowledge of their entropy can reveal the presence of microscopic electron transfer dynamics, that are difficult to observe otherwise. Here, we…

Mesoscale and Nanoscale Physics · Physics 2021-12-08 Eugenia Pyurbeeva , Chunwei Hsu , David Vogel , Christina Wegeberg , Marcel Mayor , Herre van der Zant , Jan A. Mol , Pascal Gehring

Acquiring quantitative information on charge transfer (CT) dynamics at the nanoscale remains an important scientific challenge. In particular, CT processes in single molecules at surfaces needs to be investigated to be properly controlled…

Mesoscale and Nanoscale Physics · Physics 2017-06-20 Hatem Labidi , Henry Pinto , Jerzy Leszczynski , Damien Riedel

Single molecule detection has revolutionised the fields of chemistry and biology by offering powerful ways to study individual molecules under different scenarios. Nanophotonic structures, including plasmonic antennas, significantly…

Biological Physics · Physics 2022-01-31 Pamina M. Winkler , Thomas S. van Zanten , Satyajit Mayor , Maria F. Garcia-Parajo

We present a short review of various experiments that measure charge transfer and charge transport in DNA. Some general comments are made on the possible connection between 'chemistry-style' charge transfer experiments that probe…

Disordered Systems and Neural Networks · Physics 2009-11-10 N. P. Armitage , M. Briman , G. Gruner

We present the first proof-of-concept simulations of detectors using biomaterials to detect particle interactions. The essential idea behind a "DNA detector" involves the attachment of a forest of precisely-sequenced single or…

The sensitive conductance change of semiconductor nanowires and carbon nanotubes in response to binding of charged molecules provide a novel sensing modality which is generally denoted as nanoFET sensors. In this paper, we study the scaling…

Materials Science · Physics 2009-11-13 Fu-Shan Zhou , Qi-Huo Wei

We demonstrate a novel technique for the measurement of the charge carried by a colloidal particle. The technique uses the phenomenon of the resonance of a particle held in an optical tweezers trap and driven by a sinusoidal electric field.…

Soft Condensed Matter · Physics 2007-05-23 G. Seth Roberts , Tiffany A. Wood , William J. Frith , Paul Bartlett

Light sources on the scale of single molecules can be addressed and characterized on their proper sub-nanometer scale by scanning tunneling microscopy induced luminescence (STML). Such a source can be driven by defined short charge pulses…

Mesoscale and Nanoscale Physics · Physics 2021-06-15 Anna Rosławska , Pablo Merino , Christopher C. Leon , Abhishek Grewal , Markus Etzkorn , Klaus Kuhnke , Klaus Kern

The manipulation of nanoscale matter has the potential to revolutionize a variety of fields across nanoscience and technology. Here, we demonstrate experimentally and characterize numerically a device that combines the benefits of…

Mesoscale and Nanoscale Physics · Physics 2024-08-13 Marco Riccardi , Olivier J. F. Martin

We introduce a theoretical and numerical method to investigate the flow of charged fluid mixtures under extreme confinement. We model the electrolyte solution as a ternary mixture, comprising two ionic species of opposite charge and a third…

Mesoscale and Nanoscale Physics · Physics 2012-09-13 Umberto Marini Bettolo Marconi , Simone Melchionna

Functionalization of nanoparticles or colloids is increasingly being used to develop customizable "atoms". Functionalization by attaching single strands of DNA allows for direct control of the binding between nanoparticles, since…

Soft Condensed Matter · Physics 2019-10-24 Chia Wei Hsu , Julio Largo , Francesco Sciortino , Francis W. Starr

Achieving dynamic manipulation and control of single molecules at high spatio-temporal resolution is pivotal for advancing atomic-scale computing and nanorobotics. However, this endeavour is critically challenged by complex nature of atomic…

Atomic and Molecular Clusters · Physics 2024-06-18 Divyam Neer Verma , KV Chinmaya , Jan Heck , G Mohan Rao , Sonia Contera , Moumita Ghosh , Siddharth Ghosh
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