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In this review article, we focus on emerging nanocantilever based biological sensors and discuss the response of nanocantilevers towards bio-molecules capture. The article guides the reader through various modes of operation (e.g., static…

Instrumentation and Detectors · Physics 2013-05-30 Ankit Jain , Muhammad Ashraful Alam

Nanoscale molecular systems such as DNA require an atomistic quantum treatment to accurately capture their electrical properties, owing to their small dimensions. A central challenge in modeling transport through these systems is the…

Other Condensed Matter · Physics 2026-03-09 Hashem Mohammad , M. P. Anantram

We present an electron tomography method that allows for the identification of hundreds of electrocatalyst nanoparticles with one-to-one correspondence before and after electrochemical aging. This method allows us to track, in…

Many types of molecular motors have been proposed and synthesized in recent years, displaying different kinds of motion, and fueled by different driving forces such as light, heat, or chemical reactions. We propose a new type of molecular…

Mesoscale and Nanoscale Physics · Physics 2010-11-24 Johannes S. Seldenthuis , Ferry Prins , Joseph M. Thijssen , Herre S. J. van der Zant

Fundamental mechanisms of energy storage, corrosion, sensing, and multiple biological functionalities are directly coupled to electrical processes and ionic dynamics at solid-liquid interfaces. In many cases, these processes are spatially…

Materials Science · Physics 2017-01-25 Liam Collins , Jason Kilpatrick , Sergei V. Kalinin , Brian J. Rodriguez

The entropy of a system gives a powerful insight into its microscopic degrees of freedom, however standard experimental ways of measuring entropy through heat capacity are hard to apply in mesoscale and nanoscale systems, as they require…

Mesoscale and Nanoscale Physics · Physics 2021-06-09 E. Pyurbeeva , J. A. Mol

This paper aims at a comprehensive understanding on the novel elastic property of double-stranded DNA (dsDNA) discovered very recently through single-molecule manipulation techniques. A general elastic model for double-stranded biopolymers…

Soft Condensed Matter · Physics 2009-10-31 Haijun Zhou , Yang Zhang , Zhong-can Ou-Yang

Gel electrophoresis is a powerful experimental method to probe the topology of DNA and other biopolymers. While there is a large body of experimental work which allows us to accurately separate different topoisomers of a molecule, a full…

Soft Condensed Matter · Physics 2016-02-17 Davide Michieletto , Davide Marenduzzo , Enzo Orlandini

The mechanical properties of molecules are today captured by single molecule manipulation experiments, so that polymer features are tested at a nanometric scale. Yet devising mathematical models to get further insight beyond the commonly…

It is a standard exercise in mechanical engineering to infer the external forces and torques on a body from its static shape and known elastic properties. Here we apply this kind of analysis to distorted double-helical DNA in complexes with…

Biomolecules · Quantitative Biology 2009-11-13 Nils B. Becker , Ralf Everaers

Nanopores spanning synthetic membranes have been used as key components in proof-of-principle nanofluidic applications, particularly those involving manipulation of biomolecules or sequencing of DNA. The only practical way of manipulating…

Mesoscale and Nanoscale Physics · Physics 2016-09-21 Tom Chou

We present a very simple model for the study of charge transport in a molecule patterned on B-DNA. In this model we use a discrete non-linear Schr\"{o}dinger equation to describe electrons propagating along the sugar-phosphate backbone of…

Soft Condensed Matter · Physics 2009-11-10 Niels R. Walet , Wojtek J. Zakrzewski

The electrical properties of DNA molecules are investigated by charge injection and electric force microscopy experiments. Prior to injection, DNA molecules exhibit a weak positively charged state. We probe the electrical behaviour of DNA…

Materials Science · Physics 2009-11-10 Thomas Heim , Thierry Melin , Dominique Deresmes , Dominique Vuillaume

We demonstrate electronic sensing of DNA nanostar (NS) condensate. Specifically, we use electrokinetic nanofluidics to observe and interpret how temperature-induced NS condensation affects nanochannel current. The increase in current upon…

Soft Condensed Matter · Physics 2025-05-16 Kuang-Hua Chou , Alexander Eden , David E. Huber , Sumita Pennathur , Deborah Kuchnir Fygenson

Throughout our history, we, humans, have sought to better control and understand our environment. To this end, we have extended our natural senses with a host of sensors-tools that enable us to detect both the very large, such as the…

Biological Physics · Physics 2023-06-09 Kherim Willems

The use of electrophoretic forces to tune friction at material-nanoparticle-liquid interfaces with static or low frequency (0.6-50 mHz) electric fields is reported for the first time. External electric fields were employed to reposition…

Soft Condensed Matter · Physics 2019-01-31 Biplav Acharya , Caitlin M. Seed , Donald W. Brenner , Alex I. Smirnov , Jacqueline Krim

Two forms of G4-DNA, with parallel and pairwise anti-parallel strands, are studied using atomic force microscopy. The directionality of the strands affects the molecules' structural properties (different height and length) and their…

Biological Physics · Physics 2014-10-08 Gideon I. Livshits , Jamal Ghabboun , Natalia Borovok , Alexander B. Kotlyar , Danny Porath

The purpose of this project is to investigate the use of charge couple devices (CCDs) to detect electrons directly. This can be done in transmission electron microscopy (TEM) for electrons over 100 KeV, but for space plasma instruments,…

Instrumentation and Detectors · Physics 2015-10-28 S. R. Mirfayzi

Sensors that are able to detect and track single unlabelled biomolecules are an important tool both to understand biomolecular dynamics and interactions at nanoscale, and for medical diagnostics operating at their ultimate detection limits.…

Optics · Physics 2016-11-15 N. P. Mauranyapin , L. S. Madsen , M. A. Taylor , M. Waleed , W. P. Bowen

The molecular arrangement of lipids and proteins within biomembranes and monolayers gives rise to complex film morphologies as well as regions of distinct electrical surface potential, topographical and electrostatic nanoscale domains. To…

Soft Condensed Matter · Physics 2016-11-28 Elizabeth Drolle , W. F. D. Bennett , K. Hammond , Edward Lyman , Mikko Karttunen , Zoya Leonenko