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In Fluorescein Angiography (FA), an exogenous dye is injected in the bloodstream to image the vascular structure of the retina. The injected dye can cause adverse reactions such as nausea, vomiting, anaphylactic shock, and even death. In…

Image and Video Processing · Electrical Eng. & Systems 2022-05-02 Sharif Amit Kamran , Khondker Fariha Hossain , Alireza Tavakkoli , Stewart Lee Zuckerbrod , Salah A. Baker

Diabetic Retinopathy (DR) is a leading cause of blindness in working age adults. DR lesions can be challenging to identify in fundus images, and automatic DR detection systems can offer strong clinical value. Of the publicly available…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Qiqi Xiao , Jiaxu Zou , Muqiao Yang , Alex Gaudio , Kris Kitani , Asim Smailagic , Pedro Costa , Min Xu

Blindness in diabetic patients caused by retinopathy (characterized by an increase in the diameter and new branches of the blood vessels inside the retina) is a grave concern. Many efforts have been made for the early detection of the…

Image and Video Processing · Electrical Eng. & Systems 2019-10-29 Debojyoti Mallick , Kundan Kumar , Sumanshu Agarwal

Geographic atrophy (GA) is a key biomarker of dry age-related macular degeneration (AMD) traditionally identified through color fundus photography. Hyper-transmission defects (hyperTDs), a feature highly correlated with GA, have recently…

Quantitative Methods · Quantitative Biology 2025-11-04 Yukun Guo , An-Lun Wu , Tristan T. Hormel , Liqin Gao , Min Gao , Thomas S. Hwang , Steven T. Bailey , Yali Jia

Diabetic Retinopathy (DR) is a major cause of blindness worldwide, caused by damage to the blood vessels in the retina due to diabetes. Early detection and classification of DR are crucial for timely intervention and preventing vision loss.…

Image and Video Processing · Electrical Eng. & Systems 2025-01-07 Debjany Ghosh Aronno , Sumaiya Saeha

Diabetic retinopathy (DR) is the primary cause of vision loss among grownup people around the world. In four out of five cases having diabetes for a prolonged period leads to DR. If detected early, more than 90 percent of the new DR…

Computer Vision and Pattern Recognition · Computer Science 2020-06-16 Niloy Sikder , Md. Sanaullah Chowdhury , Abu Shamim Mohammad Arif , Abdullah-Al Nahid

Glaucoma is the leading cause of irreversible but preventable blindness in the world. Its major treatable risk factor is the intra-ocular pressure, although other biomarkers are being explored to improve the understanding of the…

Computer Vision and Pattern Recognition · Computer Science 2018-10-26 José Ignacio Orlando , João Barbosa Breda , Karel van Keer , Matthew B. Blaschko , Pablo J. Blanco , Carlos A. Bulant

Diabetic retinopathy (DR) is a complication of diabetes that severely affects eyes. It can be graded into five levels of severity according to international protocol. However, optimizing a grading model to have strong generalizability…

Image and Video Processing · Electrical Eng. & Systems 2020-12-22 Yi Zhou , Boyang Wang , Xiaodong He , Shanshan Cui , Ling Shao

Predicting future disease progression risk from medical images is challenging due to patient heterogeneity, and subtle or unknown imaging biomarkers. Moreover, deep learning (DL) methods for survival analysis are susceptible to image domain…

Diabetic Retinopathy (DR) affects individuals with long-term diabetes. Without early diagnosis, DR can lead to vision loss. Fundus photography captures the structure of the retina along with abnormalities indicative of the stage of the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Anca Mihai , Adrian Groza

Diabetic Retinopathy (DR) is a leading cause of preventable blindness among working-age adults worldwide, yet most automated screening systems are limited to image-level classification and lack clinically structured reporting. We propose…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Abdelrahman Zaian , Sheethal Bhat , Mohamed Abdalkader , Andreas Maier

We aim to enhance ophthalmologists' decision-making when diagnosing the Neovascular Age-Related Macular Degeneration (nAMD). We developed three tools to analyze Optical Coherence Tomography Angiography images: (1) extracting biomarkers such…

Image and Video Processing · Electrical Eng. & Systems 2026-01-28 MAria Simona Tivadar , Ioana Damian , Adrian Groza , Simona Delia Nicoara

Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the…

Tissues and Organs · Quantitative Biology 2016-04-19 Arianna Bianchi , Kevin J. Painter , Jonathan A. Sherratt

Diabetic eye disease is one of the fastest growing causes of preventable blindness. With the advent of anti-VEGF (vascular endothelial growth factor) therapies, it has become increasingly important to detect center-involved diabetic macular…

Diabetic Retinopathy (DR) stands as the leading cause of blindness globally, particularly affecting individuals between the ages of 20 and 70. This paper presents a Computer-Aided Diagnosis (CAD) system designed for the automatic…

Computer Vision and Pattern Recognition · Computer Science 2024-08-31 Inas Al-Kamachy , Reza Hassanpour , Roya Choupani

Angiogenesis is a multiscale process by which a primary blood vessel issues secondary vessel sprouts that reach regions lacking oxygen. Angiogenesis can be a natural process of organ growth and development or a pathological induced by a…

Analysis of PDEs · Mathematics 2022-10-28 Björn Birnir , Luis Bonilla , Manuel Carretero , Filippo Terragni

Diabetic macular edema (DME) is a severe complication of diabetes, characterized by thickening of the central portion of the retina due to accumulation of fluid. DME is a significant and common cause of visual impairment in diabetic…

Image and Video Processing · Electrical Eng. & Systems 2024-12-11 Pengyao Qin , Arun J. Thirunavukarasu , Theodoros Arvanitis , Le Zhang

Angiogenesis is the formation of new blood vessels from pre-existing ones in response to chemical signals secreted by, for example, a wound or a tumour. In this paper, we propose a mesoscopic lattice-based model of angiogenesis, in which…

Tissues and Organs · Quantitative Biology 2016-03-02 Fabian Spill , Pilar Guerrero , Tomas Alarcon , Philip K. Maini , Helen M. Byrne

Diabetic Retinopathy (DR) refers to a barrier that takes place in diabetes mellitus damaging the blood vessel network present in the retina. This may endanger the subjects' vision if they have diabetes. It can take some time to perform a DR…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 V. Banupriya , S. Anusuya