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COVID-19 has shown the importance of having a fast response against pandemics. Finding a novel drug is a very long and complex procedure, and it is possible to accelerate the preliminary phases by using computer simulations. In particular,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-09-13 Emanuele Vitali , Federico Ficarelli , Mauro Bisson , Davide Gadioli , Massimiliano Fatica , Andrea R. Beccari , Gianluca Palermo

The frequent elements problem, a key component in demanding stream-data analytics, involves selecting elements whose occurrence exceeds a user-specified threshold. Fast, memory-efficient $\epsilon$-approximate synopsis algorithms select all…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-09-04 Victor Jarlow , Charalampos Stylianopoulos , Marina Papatriantafilou

Motivation: Next-generation sequencing tools have enabled producing of huge amount of genomic information at low cost. Unfortunately, presence of sequencing errors in such data affects quality of downstream analyzes. Accuracy of them can be…

Genomics · Quantitative Biology 2017-03-03 Maciej Dlugosz , Sebastian Deorowicz

Large language models (LLMs) are increasingly deployed on customer devices. To support them, current devices are adopting SoCs (System on Chip) with NPUs (Neural Processing Unit) installed. Although high performance is expected, LLM…

Hardware Architecture · Computer Science 2025-11-17 Jianyu Wei , Qingtao Li , Shijie Cao , Lingxiao Ma , Zixu Hao , Yanyong Zhang , Xiaoyan Hu , Ting Cao

LLM decoding is bottlenecked for large batches and long contexts by loading the key-value (KV) cache from high-bandwidth memory, which inflates per-token latency, while the sequential nature of decoding limits parallelism. We analyze the…

Machine Learning · Computer Science 2025-05-28 Ted Zadouri , Hubert Strauss , Tri Dao

Current AI code generation systems suffer from significant latency bottlenecks due to CPU-GPU data transfers during compilation, execution, and testing phases. We establish theoretical foundations for three complementary approaches to…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-15 Adilet Metinov , Gulida M. Kudakeeva , Gulnara D. Kabaeva

We develop a new class of genetic algorithm that computationally determines efficient pulse sequences to implement a quantum gate U in a three-qubit system. The method is shown to be quite general, and the same algorithm can be used to…

Quantum Physics · Physics 2009-12-04 Ashok Ajoy , Anil Kumar

Accurately matching local features between a pair of images is a challenging computer vision task. Previous studies typically use attention based graph neural networks (GNNs) with fully-connected graphs over keypoints within/across images…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Zizhuo Li , Jiayi Ma

Comparative analysis of adaptive immune repertoires at population scale is hampered by two practical bottlenecks: the near-quadratic cost of pairwise affinity evaluations and dataset imbalances that obscure clinically important minority…

Machine Learning · Computer Science 2026-04-14 Rong Fu , Zijian Zhang , Kun Liu , Jiekai Wu , Xianda Li , Simon Fong

As large language models move toward million-token context windows, CPU tokenizers become a major slowdown because they process text one step at a time while powerful GPUs sit unused. We built a GPU-based byte-level BPE tokenizer that…

Computation and Language · Computer Science 2026-03-04 Venu Gopal Kadamba , Kanishkha Jaisankar

Attention mechanisms underpin the success of large language models (LLMs), yet their substantial computational and memory overhead poses challenges for optimizing efficiency and performance. A critical bottleneck arises as KV cache and…

Computation and Language · Computer Science 2025-07-24 Luoyang Sun , Cheng Deng , Jiwen Jiang , Xinjian Wu , Haifeng Zhang , Lei Chen , Lionel Ni , Jun Wang

Parameter-Efficient Fine-tuning (PEFT) facilitates the fine-tuning of Large Language Models (LLMs) under limited resources. However, the fine-tuning performance with PEFT on complex, knowledge-intensive tasks is limited due to the…

Computation and Language · Computer Science 2024-06-10 Jitai Hao , WeiWei Sun , Xin Xin , Qi Meng , Zhumin Chen , Pengjie Ren , Zhaochun Ren

General Purpose Graphics Processing Unit (GPGPU) computing plays a transformative role in deep learning and machine learning by leveraging the computational advantages of parallel processing. Through the power of Compute Unified Device…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-20 Ming Li , Ziqian Bi , Tianyang Wang , Yizhu Wen , Qian Niu , Xinyuan Song , Zekun Jiang , Junyu Liu , Benji Peng , Sen Zhang , Xuanhe Pan , Jiawei Xu , Jinlang Wang , Keyu Chen , Caitlyn Heqi Yin , Pohsun Feng , Ming Liu

Genetic Programming (GP) is a computationally intensive technique which is naturally parallel in nature. Consequently, many attempts have been made to improve its run-time from exploiting highly parallel hardware such as GPUs. However, a…

Neural and Evolutionary Computing · Computer Science 2018-09-21 Darren M. Chitty

A string matching -- and more generally, sequence matching -- algorithm is presented that has a linear worst-case computing time bound, a low worst-case bound on the number of comparisons (2n), and sublinear average-case behavior that is…

Data Structures and Algorithms · Computer Science 2008-10-02 David R. Musser , Gor V. Nishanov

Quantitative MRI (qMRI) offers tissue-specific biomarkers that can be tracked over time or compared across populations; however, its adoption in clinical research is hindered by significant computational demands of parameter estimation.…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 Kwok-Shing Chan , Hansol Lee , Yixin Ma , Berkin Bilgic , Susie Y. Huang , Hong-Hsi Lee , José P. Marques

In order to satisfy timing constraints, modern real-time applications require massively parallel accelerators such as General Purpose Graphic Processing Units (GPGPUs). Generation after generation, the number of computing clusters made…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-05-24 Houssam-Eddine Zahaf , Ignacio Sanudo Olmedo , Jayati Singh , Nicola Capodieci , Sebastien Faucou

Pairwise sequence alignment is one of the most computationally intensive kernels in genomic data analysis, accounting for more than 90% of the runtime for key bioinformatics applications. This method is particularly expensive for…

Sequence Alignment is the process of aligning biological sequences in order to identify similarities between multiple sequences. In this paper, a Quantum Algorithm for finding the optimal alignment between DNA sequences has been…

Data Structures and Algorithms · Computer Science 2025-09-05 Md. Rabiul Islam Khan , Shadman Shahriar , Shaikh Farhan Rafid

This paper presents an efficient parallel Adaptive Inverse Distance Weighting (AIDW) interpolation algorithm on modern Graphics Processing Unit (GPU). The presented algorithm is an improvement of our previous GPU-accelerated AIDW algorithm…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-09-09 Gang Mei , Nengxiong Xu , Liangliang Xu