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Mediation analysis aims to separate the indirect effect through mediators from the direct effect of the exposure on the outcome. It is challenging to perform mediation analysis with neuroimaging data which involves high dimensionality,…

Methodology · Statistics 2025-12-30 Yuliang Xu , Timothy D Johnson , Mary Heitzeg , Jian Kang

Functional near-infrared spectroscopy (fNIRS) is a non-invasive, low-cost method used to study the brain's blood flow pattern. Such patterns can enable us to classify performed by a subject. In recent research, most classification systems…

Machine Learning · Computer Science 2021-01-18 Sajila D. Wickramaratne , MD Shaad Mahmud

Functional neuroimaging measures how the brain responds to complex stimuli. However, sample sizes are modest, noise is substantial, and stimuli are high dimensional. Hence, direct estimates are inherently imprecise and call for…

Applications · Statistics 2016-02-05 Leila Wehbe , Aaditya Ramdas , Rebecca C. Steorts , Cosma Rohilla Shalizi

Fetal functional Magnetic Resonance Imaging (fMRI) has emerged as a powerful tool for investigating brain development in utero, holding promise for generating developmental disease biomarkers and supporting prenatal diagnosis. However, to…

Functional magnetic resonance imaging (fMRI) techniques have contributed significantly to our understanding of brain function. Current methods are based on the analysis of \emph{gradual and continuous} changes in the brain blood oxygenated…

Neurons and Cognition · Quantitative Biology 2011-07-25 Enzo Tagliazucchi , Pablo Balenzuela , Daniel Fraiman , Dante R. Chialvo

Graphical models, used to express conditional dependence between random variables observed at various nodes, are used extensively in many fields such as genetics, neuroscience, and social network analysis. While most current statistical…

Methodology · Statistics 2022-10-25 Jiajing Niu , Boyoung Hur , John Absher , D. Andrew Brown

Currently there is no validated objective measure of pain. Recent neuroimaging studies have explored the feasibility of using functional near-infrared spectroscopy (fNIRS) to measure alterations in brain function in evoked and ongoing pain.…

Machine Learning · Computer Science 2018-08-22 Daniel Lopez-Martinez , Ke Peng , Sarah C. Steele , Arielle J. Lee , David Borsook , Rosalind Picard

The goals of functional Magnetic Resonance Imaging (fMRI) include high spatial and temporal resolutions with a high signal-to-noise ratio (SNR). To simultaneously improve spatial and temporal resolutions and maintain the high SNR advantage…

Image and Video Processing · Electrical Eng. & Systems 2024-07-10 Shouchang Guo

Accurate segmentation of brain tissue in magnetic resonance images (MRI) is a diffcult task due to different types of brain abnormalities. Using information and features from multimodal MRI including T1, T1-weighted inversion recovery…

Computer Vision and Pattern Recognition · Computer Science 2019-03-07 Yongpei Zhu , Zicong Zhou , Guojun Liao , Qianxi Yang , Kehong Yuan

The universal tendency in scanning probe microscopy (SPM) over the last two decades is to transition from simple 2D imaging to complex detection and spectroscopic imaging modes. The emergence of complex SPM engines brings forth the…

Resting state fMRI is an imaging modality which reveals brain activity localization through signal changes, in what is known as Resting State Networks (RSNs). This technique is gaining popularity in neurosurgical pre-planning to visualize…

Machine Learning · Computer Science 2022-09-22 Sejal Ghate , Alberto Santamaria-Pang , Ivan Tarapov , Haris I Sair , Craig K Jones

Major depressive disorder (MDD) requires study of brain functional connectivity alterations for patients, which can be uncovered by resting-state functional magnetic resonance imaging (rs-fMRI) data. We consider the problem of identifying…

Machine Learning · Statistics 2022-06-10 Shuai Liu , Yixuan Qiu , Baojuan Li , Huaning Wang , Xiangyu Chang

Functional magnetic resonance imaging (fMRI) provides an indirect measurement of neuronal activity via hemodynamic responses that vary across brain regions and individuals. Ignoring this hemodynamic variability can bias downstream…

Image and Video Processing · Electrical Eng. & Systems 2026-01-26 William Consagra , Eardi Lila

In neuroimaging studies, it becomes increasingly important to study associations between different imaging modalities using image-on-image regression (IIR), which faces challenges in interpretation, statistical inference, and prediction.…

Applications · Statistics 2026-03-24 Guoxuan Ma , Bangyao Zhao , Hasan Abu-Amara , Jian Kang

Functional magnetic resonance imaging (fMRI) based image reconstruction plays a pivotal role in decoding human perception, with applications in neuroscience and brain-computer interfaces. While recent advancements in deep learning and…

Computer Vision and Pattern Recognition · Computer Science 2025-02-25 Weiyu Guo , Guoying Sun , JianXiang He , Tong Shao , Shaoguang Wang , Ziyang Chen , Meisheng Hong , Ying Sun , Hui Xiong

Functional magnetic resonance imaging (fMRI) is a non-invasive and in-vivo imaging technique essential for measuring brain activity. Functional connectivity is used to study associations between brain regions, either while study subjects…

Applications · Statistics 2024-03-26 Kun Meng , Ani Eloyan

Diffusion models have recently emerged as powerful generative models in medical imaging. However, it remains a major challenge to combine these data-driven models with domain knowledge to guide brain imaging problems. In neuroimaging,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Ana Lawry Aguila , Dina Zemlyanker , You Cheng , Sudeshna Das , Daniel C. Alexander , Oula Puonti , Annabel Sorby-Adams , W. Taylor Kimberly , Juan Eugenio Iglesias

Scaling temporal dynamics in functional MRI (fMRI) signals have been evidenced for a decade as intrinsic characteristics of ongoing brain activity (Zarahn et al., 1997). Recently, scaling properties were shown to fluctuate across brain…

Statistics Theory · Mathematics 2013-08-21 P. Ciuciu , G. Varoquaux , P. Abry , S. Sadaghiani , A. Kleinschmidt

Functional MRI (fMRI) is widely used to examine brain functionality by detecting alteration in oxygenated blood flow that arises with brain activity. This work aims to investigate the neurological variation of human brain responses during…

Computer Vision and Pattern Recognition · Computer Science 2023-09-28 Naveen Kanigiri , Manohar Suggula , Debanjali Bhattacharya , Neelam Sinha

Neuroimaging-based prediction methods for intelligence and cognitive abilities have seen a rapid development in literature. Among different neuroimaging modalities, prediction based on functional connectivity (FC) has shown great promise.…

Neurons and Cognition · Quantitative Biology 2023-07-20 Yang Li , Xin Ma , Raj Sunderraman , Shihao Ji , Suprateek Kundu