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We explore the relationship among model fidelity, experimental design, and parameter estimation in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many…

Quantitative Methods · Quantitative Biology 2017-02-08 Andrew White , Malachi Tolman , Howard D. Thames , Hubert Rodney Withers , Kathy A. Mason , Mark K. Transtrum

Interaction with Large Language Models (LLMs) is primarily carried out via prompting. A prompt is a natural language instruction designed to elicit certain behaviour or output from a model. In theory, natural language prompts enable…

Human-Computer Interaction · Computer Science 2024-03-15 Michael Desmond , Michelle Brachman

The goal of experiment design is to select the inputs of a dynamical system in such a way that the resulting data contain sufficient information for system identification and data-driven control. This paper investigates the problem of…

Optimization and Control · Mathematics 2026-04-10 Jiwei Wang , Simone Baldi , Henk J. van Waarde

Measuring innovation often relies on context-specific proxies and on expert evaluation. Hence, empirical innovation research is often limited to settings where such data is available. We investigate how large language models (LLMs) can be…

Computation and Language · Computer Science 2025-08-05 Robin Nowak , Patrick Figge , Carolin Haeussler

We extend the approach in [Ann. Statist. 38 (2010) 2499-2524] for identifying locally optimal designs for nonlinear models. Conceptually the extension is relatively simple, but the consequences in terms of applications are profound. As we…

Statistics Theory · Mathematics 2012-10-04 Min Yang , John Stufken

Recent advances in LLM have been instrumental in autonomous robot control and human-robot interaction by leveraging their vast general knowledge and capabilities to understand and reason across a wide range of tasks and scenarios. Previous…

Robotics · Computer Science 2024-11-07 Jonas Bode , Bastian Pätzold , Raphael Memmesheimer , Sven Behnke

Fine-tuning large language models (LLMs) with limited data poses a practical challenge in low-resource languages, specialized domains, and constrained deployment settings. While pre-trained LLMs provide strong foundations, effective…

Computation and Language · Computer Science 2025-10-29 Marton Szep , Daniel Rueckert , Rüdiger von Eisenhart-Rothe , Florian Hinterwimmer

Large language models (LLMs) are widely used as zero-shot and few-shot classifiers, where task behaviour is largely controlled through prompting. A growing number of works have observed that LLMs are sensitive to prompt variations, with…

Computation and Language · Computer Science 2026-02-05 Branislav Pecher , Michal Spiegel , Robert Belanec , Jan Cegin

We consider the problem of constructing optimal designs for model discrimination between competing regression models. Various new properties of optimal designs with respect to the popular $T$-optimality criterion are derived, which in many…

Statistics Theory · Mathematics 2009-08-14 Holger Dette , Stefanie Titoff

Algorithm design is crucial for effective problem-solving across various domains. The advent of Large Language Models (LLMs) has notably enhanced the automation and innovation within this field, offering new perspectives and promising…

Machine Learning · Computer Science 2026-01-06 Fei Liu , Yiming Yao , Ping Guo , Zhiyuan Yang , Zhe Zhao , Xi Lin , Xialiang Tong , Kun Mao , Zhichao Lu , Zhenkun Wang , Mingxuan Yuan , Qingfu Zhang

Linear mixed models (LMMs) are a powerful and established tool for studying genotype-phenotype relationships. A limiting assumption of LMMs is that the residuals are Gaussian distributed, a requirement that rarely holds in practice.…

Genomics · Quantitative Biology 2014-08-10 Nicolo Fusi , Christoph Lippert , Neil D. Lawrence , Oliver Stegle

Subsampling or subdata selection is a useful approach in large-scale statistical learning. Most existing studies focus on model-based subsampling methods which significantly depend on the model assumption. In this paper, we consider the…

Methodology · Statistics 2022-09-09 Mei Zhang , Yongdao Zhou , Zheng Zhou , Aijun Zhang

We introduce estimation and test procedures through divergence minimization for models satisfying linear constraints with unknown parameter. Several statistical examples and motivations are given. These procedures extend the empirical…

Statistics Theory · Mathematics 2008-11-24 Michel Broniatowski , Amor Keziou

Random field models have been widely employed to develop a predictor of an expensive function based on observations from an experiment. The traditional framework for developing a predictor with random field models can fail due to the…

Methodology · Statistics 2014-12-05 Matthew Plumlee

Many applications of machine learning methods involve an iterative protocol in which data are collected, a model is trained, and then outputs of that model are used to choose what data to consider next. For example, one data-driven approach…

Machine Learning · Computer Science 2025-04-07 Clara Fannjiang , Stephen Bates , Anastasios N. Angelopoulos , Jennifer Listgarten , Michael I. Jordan

Model-based trees are used to find subgroups in data which differ with respect to model parameters. In some applications it is natural to keep some parameters fixed globally for all observations while asking if and how other parameters vary…

Computation · Statistics 2025-10-07 Heidi Seibold , Torsten Hothorn , Achim Zeileis

LLMs are increasingly used to make or support high-stakes decisions under uncertainty, where alignment depends not only on factual accuracy but on how models weigh tradeoffs between different outcomes. We present an empirical pipeline for…

Machine Learning · Computer Science 2026-05-12 Khurram Yamin , Jingjing Tang , Eric Horvitz , Bryan Wilder

General log-linear models specified by non-negative integer design matrices have a potentially wide range of applications, although using models without the genuine overall effect, that is, ones which cannot be reparameterized to include a…

Methodology · Statistics 2023-01-02 Anna Klimova , Matthias Kuhn

This paper discusses minimum distance estimation method in the linear regression model with dependent errors which are strongly mixing. The regression parameters are estimated through the minimum distance estimation method, and asymptotic…

Statistics Theory · Mathematics 2017-01-06 Jiwoong Kim

For large classes of group testing problems, we derive lower bounds for the probability that all significant items are uniquely identified using specially constructed random designs. These bounds allow us to optimize parameters of the…

Statistics Theory · Mathematics 2022-02-17 Jack Noonan , Anatoly Zhigljavsky