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Opioid addiction has become a global epidemic and a national health crisis in recent years, with the number of opioid overdose fatalities steadily increasing since the 1990s. In contrast to the dynamics of a typical illicit drug or disease…

Given the current social distance restrictions across the world, most individuals now use social media as their major medium of communication. Millions of people suffering from mental diseases have been isolated due to this, and they are…

Occupational data mining and analysis is an important task in understanding today's industry and job market. Various machine learning techniques are proposed and gradually deployed to improve companies' operations for upstream tasks, such…

Multi-stage disease histories derived from longitudinal data are becoming increasingly available as registry data and biobanks expand. Multi-state models are suitable to investigate transitions between different disease stages in presence…

The Early diagnosis and treatment of depression is essential for effective treatment. Depression, while being one of the most common mental illnesses, is still poorly understood in both research and clinical practice. Among different…

Disease progression modeling provides a robust framework to identify long-term disease trajectories from short-term biomarker data. It is a valuable tool to gain a deeper understanding of diseases with a long disease trajectory, such as…

Health sensing for chronic disease management creates immense benefits for social welfare. Existing health sensing studies primarily focus on the prediction of physical chronic diseases. Depression, a widespread complication of chronic…

INTRODUCTION: The pharmacological treatment of Major Depressive Disorder (MDD) relies on a trial-and-error approach. We introduce an artificial intelligence (AI) model aiming to personalize treatment and improve outcomes, which was deployed…

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of…

Prognostic task is of great importance as it closely related to the survival analysis of patients, the optimization of treatment plans and the allocation of resources. The existing prognostic models have shown promising results on specific…

The opioid epidemic continues to ravage communities worldwide, straining healthcare systems, disrupting families, and demanding urgent computational solutions. To combat this lethal opioid crisis, graph learning methods have emerged as a…

Voice disorders are pathologies significantly affecting patient quality of life. However, non-invasive automated diagnosis of these pathologies is still under-explored, due to both a shortage of pathological voice data, and diversity of the…

Drug repurposing has historically been an economically infeasible process for identifying novel uses for abandoned drugs. Modern machine learning has enabled the identification of complex biochemical intricacies in candidate drugs; however,…

Modern medicine generates vast multimodal data across siloed systems, yet no existing model integrates the full breadth and temporal depth of the clinical record into a unified patient representation. We introduce Apollo, a multimodal…

Synthetic opioids are the most common drugs involved in drug-involved overdose mortalities in the U.S. The Center for Disease Control and Prevention reported that in 2018, about 70% of all drug overdose deaths involved opioids and 67% of…

Outlier detection (OD), distinguishing inliers and outliers in completely unlabeled datasets, plays a vital role in science and engineering. Although there have been many insightful OD methods, most of them require troublesome…

Multimodal data fusion is a key approach for enhancing diagnosis in medical applications. We propose an asymmetric fusion strategy starting from a primary modality and integrating secondary modalities by disentangling shared and…

Real-world clinical data is inherently multimodal, providing complementary evidence that mirrors the practical necessity of jointly assessing multiple related outcomes. Although multi-task learning can improve efficiency by sharing…

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve…

Depression is a serious mental health illness that significantly affects an individual's well-being and quality of life, making early detection crucial for adequate care and treatment. Detecting depression is often difficult, as it is based…