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We introduce SIM-CE, an advanced, user-friendly modeling and simulation environment in Simulink for performing multi-scale behavioral analysis of the nervous system of Caenorhabditis elegans (C. elegans). SIM-CE contains an implementation…

Neurons and Cognition · Quantitative Biology 2017-03-28 Ramin M. Hasani , Victoria Beneder , Magdalena Fuchs , David Lung , Radu Grosu

Understanding how information about external stimuli is transformed into behavior is one of the central goals of neuroscience. Here we characterize the information flow through a complete sensorimotor circuit: from stimulus, to sensory…

Neurons and Cognition · Quantitative Biology 2015-10-15 Eduardo J. Izquierdo , Paul L. Williams , Randall D. Beer

The gait generator, which is capable of producing rhythmic signals for coordinating multiple joints, is an essential component in the quadruped robot locomotion control framework. The biological counterpart of the gait generator is the…

Robotics · Computer Science 2024-06-21 Yide Liu , Xiyan Liu , Dongqi Wang , Wei Yang , shaoxing Qu

The ability to acquire large-scale recordings of neuronal activity in awake and unrestrained animals poses a major challenge for studying neural coding of animal behavior. We present a new instrument capable of recording intracellular…

Neurons and Cognition · Quantitative Biology 2015-12-31 Jeffrey P. Nguyen , Frederick B. Shipley , Ashley N. Linder , George S. Plummer , Joshua W. Shaevitz , Andrew M. Leifer

Grand efforts in neuroscience are working toward mapping the connectomes of many new species, including the near completion of the Drosophila melanogaster. It is important to ask whether these models could benefit artificial intelligence.…

Neural and Evolutionary Computing · Computer Science 2022-12-26 Samuel Schmidgall , Catherine Schuman , Maryam Parsa

Small groups of interneurons, abbreviated by CPG for central pattern generators, are arranged into neural networks to generate a variety of core bursting rhythms with specific phase-locked states, on distinct time scales, that govern vital…

Chaotic Dynamics · Physics 2015-06-17 Sajiya Jalil , Dane Allen , Joe Youker , Andrey Shilnikov

Central pattern generators (CPGs), with a basis is neurophysiological studies, are a type of neural network for the generation of rhythmic motion. While CPGs are being increasingly used in robot control, most applications are hand-tuned for…

Neural and Evolutionary Computing · Computer Science 2015-03-13 Atilim Gunes Baydin

One of the biggest challenges in biology is to understand how activity at the cellular level of neurons, as a result of their mutual interactions, leads to the observed behavior of an organism responding to a variety of environmental…

Neurons and Cognition · Quantitative Biology 2010-03-09 Raj Kumar Pan , Nivedita Chatterjee , Sitabhra Sinha

We present what we believe to be the first formal verification of a biologically realistic (nonlinear ODE) model of a neural circuit in a multicellular organism: Tap Withdrawal (TW) in \emph{C. Elegans}, the common roundworm. TW is a…

Logic in Computer Science · Computer Science 2015-03-24 Md. Ariful Islam , Richard DeFrancisco , Chuchu Fan , Radu Grosu , Sayan Mitra , Scott A. Smolka

Advanced volumetric imaging methods and genetically encoded activity indicators have permitted a comprehensive characterization of whole brain activity at single neuron resolution in \textit{Caenorhabditis elegans}. The constant motion and…

Quantitative Methods · Quantitative Biology 2022-10-12 Yuxiang Wu , Shang Wu , Xin Wang , Chengtian Lang , Quanshi Zhang , Quan Wen , Tianqi Xu

Rectilinear crawling locomotion is a primitive and common mode of locomotion in slender, soft-bodied animals. It requires coordinated contractions that propagate along a body that interacts frictionally with its environment. We propose a…

Biological Physics · Physics 2021-08-31 Shruti Mishra , Wim M. van Rees , L. Mahadevan

Abrupt changes in behavior can often be associated with changes in underlying behavioral states. When placed off food, the foraging behavior of C. elegans can be described as a change between an initial local-search behavior characterized…

Neurons and Cognition · Quantitative Biology 2025-06-03 Andrew Margolis , Andrew Gordus

Insects have tiny brains but complicated visual systems for motion perception. A handful of insect visual neurons have been computationally modeled and successfully applied for robotics. How different neurons collaborate on motion…

Neural and Evolutionary Computing · Computer Science 2019-04-16 Qinbing Fu , Cheng Hu , Pengcheng Liu , Shigang Yue

The motility of the worm nematode \textit{Caenorhabditis elegans} is investigated in shallow, wet granular media as a function of particle size dispersity and area density ($\phi$). Surprisingly, we find that the nematode's propulsion speed…

Biological Physics · Physics 2012-03-06 G. Juarez , K. Lu , J. Sznitman , P. E. Arratia

Many animals in their natural habitat exhibit collective motion and form complex patterns to tackle environmental difficulties. Several physical and biological factors, such as animal motility, population densities, and chemical cues, play…

Biological Physics · Physics 2019-06-25 Esin Demir , Y. Ilker Yaman , Askin Kocabas

A main goal in the analysis of a complex system is to infer its underlying network structure from time-series observations of its behaviour. The inference process is often done by using bi-variate similarity measures, such as the…

Disordered Systems and Neural Networks · Physics 2019-09-06 Rodrigo A. García , Arturo C. Martí , Cecilia Cabeza , Nicolás Rubido

Synchronization plays a key role in information processing in neuronal networks. Response of specific groups of neurons are triggered by external stimuli, such as visual, tactile or olfactory inputs. Neurons, however, can be divided into…

Adaptation and Self-Organizing Systems · Physics 2020-03-02 Carolina A. Moreira , Marcus A. M. de Aguiar

We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three technical challenges: it…

Neurons and Cognition · Quantitative Biology 2022-02-01 Mochi Liu , Sandeep Kumar , Anuj K Sharma , Andrew M Leifer

The video showcases how C. elegans worms respond to DC and AC electrical stimulations. Gabel et al (2007) demonstrated that in the presence of DC and low frequency AC fields, worms of stage L2 and larger propel themselves towards the…

Fluid Dynamics · Physics 2015-05-20 Han-Sheng Chuang , David Raizen , Nooreen Dabbish , Haim Bau

This paper shows that ResNets, NeuralODEs, and CT-RNNs, are particular neural regulatory networks (NRNs), a biophysical model for the nonspiking neurons encountered in small species, such as the C.elegans nematode, and in the retina of…

Neurons and Cognition · Quantitative Biology 2020-03-20 Radu Grosu
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