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The mean survival is the key ingredient of the decision process in several applications, notably in health economic evaluations. It is defined as the area under the complete survival curve, thus necessitating extrapolation of the observed…

Applications · Statistics 2026-03-10 Anastasios Apsemidis , Nikolaos Demiris

This study introduces a framework that integrates nonlinear feature extraction, classification, and efficient optimization. First, kernel principal component analysis with a radial basis function kernel reduces dimensionality while…

Machine Learning · Computer Science 2025-06-23 Iliyas Ibrahim Iliyas , Souley Boukari , Abdulsalam Yau Gital

Heart failure (HF) is a leading cause of morbidity, mortality, and health care costs. Prolonged conduction through the myocardium can occur with HF, and a device-driven approach, termed cardiac resynchronization therapy (CRT), can improve…

Machine Learning · Computer Science 2021-09-14 Brendan E. Odigwe , Francis G. Spinale , Homayoun Valafar

We study the variable selection problem in survival analysis to identify the most important factors affecting survival time. Our method incorporates prior knowledge of mutual correlations among variables, represented through a graph. We…

Statistics Theory · Mathematics 2025-04-25 Liyan Xie , Xi He , Pinar Keskinocak , Yao Xie

Chronic Kidney Disease (CKD) constitutes a major global medical burden, marked by the gradual deterioration of renal function, which results in the impaired clearance of metabolic waste and disturbances in systemic fluid homeostasis. Owing…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Anas Bin Ayub , Nilima Sultana Niha , Md. Zahurul Haque

The accurate prediction of survival times for patients with severe diseases remains a critical challenge despite recent advances in artificial intelligence. This study introduces "SurvTimeSurvival: Survival Analysis On Patients With…

Machine Learning · Computer Science 2023-11-17 Hung Le , Ong Eng-Jon , Bober Miroslaw

Survival outcome assessment is challenging and inherently associated with multiple clinical factors (e.g., imaging and genomics biomarkers) in cancer. Enabling multimodal analytics promises to reveal novel predictive patterns of patient…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Kexin Ding , Mu Zhou , Dimitris N. Metaxas , Shaoting Zhang

Survival prediction models can potentially be used to guide treatment of glioblastoma patients. However, currently available MR imaging biomarkers holding prognostic information are often challenging to interpret, have difficulties…

Image and Video Processing · Electrical Eng. & Systems 2021-09-28 Sveinn Pálsson , Stefano Cerri , Hans Skovgaard Poulsen , Thomas Urup , Ian Law , Koen Van Leemput

We introduce a statistical procedure that integrates survival data from multiple biomedical studies, to improve the accuracy of predictions of survival or other events, based on individual clinical and genomic profiles, compared to models…

Applications · Statistics 2020-07-20 Steffen Ventz , Rahul Mazumder , Lorenzo Trippa

Diabetes is a chronic disease characterised by a high risk of developing diabetic nephropathy, which, in turn, is the leading cause of end-stage chronic kidney disease. The early identification of individuals at heightened risk of such…

Quantitative Methods · Quantitative Biology 2024-09-24 Davide Dei Cas , Barbara Di Camillo , Gian Paolo Fadini , Giovanni Sparacino , Enrico Longato

Survival prediction plays a crucial role in assisting clinicians with the development of cancer treatment protocols. Recent evidence shows that multimodal data can help in the diagnosis of cancer disease and improve survival prediction.…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Ruiquan Ge , Xiangyang Hu , Rungen Huang , Gangyong Jia , Yaqi Wang , Renshu Gu , Changmiao Wang , Elazab Ahmed , Linyan Wang , Juan Ye , Ye Li

The construction of three-dimensional multi-modal tissue maps provides an opportunity to spur interdisciplinary innovations across temporal and spatial scales through information integration. While the preponderance of effort is allocated…

Acute kidney injury (AKI) commonly occurs in hospitalized patients and can lead to serious medical complications. In order to optimally predict AKI before it develops at any time during a hospital stay, we present a novel framework in which…

Quantitative Methods · Quantitative Biology 2019-02-28 Rohit J. Kate , Noah Pearce , Debesh Mazumdar , Vani Nilakantan

The classification of Antibody Mediated Rejection (AMR) in kidney transplant remains challenging even for experienced nephropathologists; this is partly because histological tissue stain analysis is often characterized by low inter-observer…

Computer Vision and Pattern Recognition · Computer Science 2020-07-13 Pietro Antonio Cicalese , Aryan Mobiny , Pengyu Yuan , Jan Becker , Chandra Mohan , Hien Van Nguyen

Heart transplantation is a viable path for patients suffering from advanced heart failure, but this lifesaving option is severely limited due to donor shortage. Although the current allocation policy was recently revised in 2018, a major…

Machine Learning · Computer Science 2025-12-16 Ioannis Anagnostides , Zachary W. Sollie , Arman Kilic , Tuomas Sandholm

Postoperative complications pose a significant challenge in the healthcare industry, resulting in elevated healthcare expenses and prolonged hospital stays, and in rare instances, patient mortality. To improve patient outcomes and reduce…

Machine Learning · Computer Science 2023-06-07 Reza Shirkavand , Fei Zhang , Heng Huang

Survival analysis is a fundamental tool for modeling time-to-event outcomes in healthcare. Recent advances have introduced flexible neural network approaches for improved predictive performance. However, most of these models do not provide…

Machine Learning · Statistics 2025-09-10 Mert Ketenci , Vincent Jeanselme , Harry Reyes Nieva , Shalmali Joshi , Noémie Elhadad

Background: Acute kidney injury (AKI) is a common complication in hospitalized patients and a common cause for chronic kidney disease (CKD) and increased hospital cost and mortality. By timely detection of AKI and AKI progression, effective…

Establishing the reproducibility of radiomic signatures is a critical step in the path to clinical adoption of quantitative imaging biomarkers; however, radiomic signatures must also be meaningfully related to an outcome of clinical…

We propose a flexible joint longitudinal-survival framework to examine the association between longitudinally collected biomarkers and a time-to-event endpoint. More specifically, we use our method for analyzing the survival outcome of…

Applications · Statistics 2018-07-09 Sepehr Akhavan Masouleh , Tracy Holsclaw , Babak Shahbaba , Daniel L. Gillen