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Histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation of histopathological cancer sections…

Image and Video Processing · Electrical Eng. & Systems 2021-12-08 André Pedersen , Erik Smistad , Tor V. Rise , Vibeke G. Dale , Henrik S. Pettersen , Tor-Arne S. Nordmo , David Bouget , Ingerid Reinertsen , Marit Valla

Deep neural networks are increasingly applied in automated histopathology. Yet, whole-slide images (WSIs) are often acquired at gigapixel sizes, rendering them computationally infeasible to analyze entirely at high resolution. Diagnostic…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Tarun G , Naman Malpani , Gugan Thoppe , Sridharan Devarajan

Pathology image segmentation is crucial in computational pathology for analyzing histological features relevant to cancer diagnosis and prognosis. However, current methods face major challenges in clinical applications due to limited…

Computer Vision and Pattern Recognition · Computer Science 2025-08-20 Zhixuan Chen , Junlin Hou , Liqi Lin , Yihui Wang , Yequan Bie , Xi Wang , Yanning Zhou , Ronald Cheong Kin Chan , Hao Chen

Segmentation is a critical task in computational pathology, as it identifies areas affected by disease or abnormal growth and is essential for diagnosis and treatment. However, acquiring high-quality pixel-level supervised segmentation data…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Zhiling Yan , Sicheng Chen , Tianyi Zhang , Nan Ying , Yanli Lei , Guanglei Zhang

Weakly supervised semantic segmentation (WSSS) aims to bypass the need for laborious pixel-level annotation by using only image-level annotation. Most existing methods rely on Class Activation Maps (CAM) to derive pixel-level pseudo-labels…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Tianle Chen , Zheda Mai , Ruiwen Li , Wei-lun Chao

High-quality pixel-level annotations of medical images are essential for supervised segmentation tasks, but obtaining such annotations is costly and requires medical expertise. To address this challenge, we propose a novel coarse-to-fine…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Anghong Du , Nay Aung , Theodoros N. Arvanitis , Stefan K. Piechnik , Joao A C Lima , Steffen E. Petersen , Le Zhang

The detection of nuclei is one of the most fundamental components of computational pathology. Current state-of-the-art methods are based on deep learning, with the prerequisite that extensive labeled datasets are available. The increasing…

Image and Video Processing · Electrical Eng. & Systems 2019-07-11 Nicolas Brieu , Armin Meier , Ansh Kapil , Ralf Schoenmeyer , Christos G. Gavriel , Peter D. Caie , Günter Schmidt

Precise identification of multiple cell classes in high-resolution Giga-pixel whole slide imaging (WSI) is critical for various clinical scenarios. Building an AI model for this purpose typically requires pixel-level annotations, which are…

Image and Video Processing · Electrical Eng. & Systems 2023-08-14 Xueyuan Li , Ruining Deng , Yucheng Tang , Shunxing Bao , Haichun Yang , Yuankai Huo

Surgical instrument segmentation is recognised as a key enabler in providing advanced surgical assistance and improving computer-assisted interventions. In this work, we propose SegMatch, a semi-supervised learning method to reduce the need…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Meng Wei , Charlie Budd , Luis C. Garcia-Peraza-Herrera , Reuben Dorent , Miaojing Shi , Tom Vercauteren

Deep convolutional neural networks have achieved remarkable progress on a variety of medical image computing tasks. A common problem when applying supervised deep learning methods to medical images is the lack of labeled data, which is very…

Computer Vision and Pattern Recognition · Computer Science 2020-05-12 Xiaomeng Li , Lequan Yu , Hao Chen , Chi-Wing Fu , Lei Xing , Pheng-Ann Heng

The rapid development of deep learning has driven significant progress in image semantic segmentation - a fundamental task in computer vision. Semantic segmentation algorithms often depend on the availability of pixel-level labels (i.e.,…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Zhaozheng Chen , Qianru Sun

Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtain across diverse tissues and staining conditions. To address…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Kazuya Nishimura , Ryoma Bise , Haruka Hirose , Yasuhiro Kojima

Recently, generative adversarial networks exhibited excellent performances in semi-supervised image analysis scenarios. In this paper, we go even further by proposing a fully unsupervised approach for segmentation applications with prior…

Computer Vision and Pattern Recognition · Computer Science 2018-08-02 Michael Gadermayr , Laxmi Gupta , Barbara M. Klinkhammer , Peter Boor , Dorit Merhof

Automated grading of prostate cancer histopathology images is a challenging task, with one key challenge being the scarcity of annotations down to the level of regions of interest (strong labels), as typically the prostate cancer Gleason…

Computer Vision and Pattern Recognition · Computer Science 2018-11-20 Eirini Arvaniti , Manfred Claassen

Often in medical imaging, it is prohibitively challenging to produce enough boundary annotations to train deep neural networks for accurate tumor segmentation. We propose the use of weak labels about whether an image presents tumor or…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Eugene Vorontsov , Pavlo Molchanov , Christopher Beckham , Jan Kautz , Samuel Kadoury

Comprehensive semantic segmentation on renal pathological images is challenging due to the heterogeneous scales of the objects. For example, on a whole slide image (WSI), the cross-sectional areas of glomeruli can be 64 times larger than…

Image and Video Processing · Electrical Eng. & Systems 2023-01-20 Ruining Deng , Quan Liu , Can Cui , Tianyuan Yao , Jun Long , Zuhayr Asad , R. Michael Womick , Zheyu Zhu , Agnes B. Fogo , Shilin Zhao , Haichun Yang , Yuankai Huo

Accurate segmentation of polyps and skin lesions is essential for diagnosing colorectal and skin cancers. While various segmentation methods for polyps and skin lesions using fully supervised deep learning techniques have been developed,…

Computer Vision and Pattern Recognition · Computer Science 2025-04-03 Encheng Su , Hu Cao , Alois Knoll

Segmentation is essential for medical image analysis tasks such as intervention planning, therapy guidance, diagnosis, treatment decisions. Deep learning is becoming increasingly prominent for segmentation, where the lack of annotations,…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Firat Ozdemir , Zixuan Peng , Christine Tanner , Philipp Fuernstahl , Orcun Goksel

One of the key challenges in the battle against the Coronavirus (COVID-19) pandemic is to detect and quantify the severity of the disease in a timely manner. Computed tomographies (CT) of the lungs are effective for assessing the state of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-15 Issam Laradji , Pau Rodriguez , Frederic Branchaud-Charron , Keegan Lensink , Parmida Atighehchian , William Parker , David Vazquez , Derek Nowrouzezahrai

Nuclei segmentation is one of the important tasks for whole slide image analysis in digital pathology. With the drastic advance of deep learning, recent deep networks have demonstrated successful performance of the nuclei segmentation task.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-23 Inwan Yoo , Donggeun Yoo , Kyunghyun Paeng