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We explore the performance of a statistical learning technique based on Gaussian Process (GP) regression as an efficient non-parametric method for constructing multi-dimensional potential energy surfaces (PES) for polyatomic molecules.…

Chemical Physics · Physics 2016-11-23 Jie Cui , Roman V. Krems

We present an accurate machine learning (ML) model for atomistic simulations of carbon, constructed using the Gaussian approximation potential (GAP) methodology. The potential, named GAP-20, describes the properties of the bulk crystalline…

Computational Physics · Physics 2020-08-26 Patrick Rowe , Volker L Deringer , Piero Gasparotto , Gábor Csányi , Angelos Michaelides

Machine learning has transformed the field of atomistic simulations by enabling the development of interatomic potentials that are computationally efficient and highly accurate. These advances have opened the door to modeling molecular…

Chemical Physics · Physics 2026-05-22 Nitik Bhatia , Ondrej Krejci , Patrick Rinke

Machine Learning Interatomic Potentials (MLIPs) sometimes fail to reproduce the physical smoothness of the quantum potential energy surface (PES), leading to erroneous behavior in downstream simulations that standard energy and force…

Machine Learning · Computer Science 2026-02-05 Ryan Liu , Eric Qu , Tobias Kreiman , Samuel M. Blau , Aditi S. Krishnapriyan

To further develop accurate and large-scale simulations of electrochemical interfaces, we propose a unified explicit electric potential framework to simultaneously predict atomic forces and electron density distributions. The framework…

Chemical Physics · Physics 2026-04-14 Jingwen Zhou , Yawen Yu , Xuwei Liu , Chungen Liu

Noncovalent interactions--vdW dispersion, hydrogen/halogen bonding, ion-$\pi$, and $\pi$-stacking--govern structure, dynamics, and emergent phenomena in materials and molecular systems, yet accurately learning them alongside covalent forces…

Chemical Physics · Physics 2025-11-05 Leonardo Cázares-Trejo , Marco Loreto-Silva , Huziel E. Sauceda

We use machine learning to enable large-scale molecular dynamics (MD) of a correlated electron model under the Gutzwiller approximation scheme. This model exhibits a Mott transition as a function of on-site Coulomb repulsion $U$. The…

Strongly Correlated Electrons · Physics 2019-04-17 Hidemaro Suwa , Justin S. Smith , Nicholas Lubbers , Cristian D. Batista , Gia-Wei Chern , Kipton Barros

Data-driven, machine learning (ML) models of atomistic interactions are often based on flexible and non-physical functions that can relate nuanced aspects of atomic arrangements into predictions of energies and forces. As a result, these…

Materials Science · Physics 2024-05-15 Bartosz Barzdajn , Christopher P. Race

Machine learning techniques are being increasingly used as flexible non-linear fitting and prediction tools in the physical sciences. Fitting functions that exhibit multiple solutions as local minima can be analysed in terms of the…

Geoenergy projects (CO2 storage, geothermal, subsurface H2 generation/storage, critical minerals from subsurface fluids, or nuclear waste disposal) increasingly follow a petroleum-style funnel from screening and appraisal to operations,…

Disordered Systems and Neural Networks · Physics 2026-03-17 Hannah P. Menke , Ahmed H. Elsheikh , Lingli Wei , Nanzhe Wang , Andreas Busch

Mesh-based simulations are central to modeling complex physical systems in many disciplines across science and engineering. Mesh representations support powerful numerical integration methods and their resolution can be adapted to strike…

Machine Learning · Computer Science 2021-06-21 Tobias Pfaff , Meire Fortunato , Alvaro Sanchez-Gonzalez , Peter W. Battaglia

We introduce GlassMLP, a machine learning framework using physics-inspired structural input to predict the long-time dynamics in deeply supercooled liquids. We apply this deep neural network to atomistic models in 2D and 3D. Its performance…

Soft Condensed Matter · Physics 2023-09-29 Gerhard Jung , Giulio Biroli , Ludovic Berthier

The accurate modeling of non-covalent interactions between helium and graphitic materials is important for understanding quantum phenomena in reduced dimensions, with the helium-benzene complex serving as the fundamental prototype. However,…

Machine learning models are changing the paradigm of molecular modeling, which is a fundamental tool for material science, chemistry, and computational biology. Of particular interest is the inter-atomic potential energy surface (PES). Here…

Computational Physics · Physics 2020-07-21 Linfeng Zhang , Jiequn Han , Han Wang , Wissam A. Saidi , Roberto Car , Weinan E

Identifying minimum-energy paths (MEPs) is crucial for understanding chemical reaction mechanisms but remains computationally demanding. We introduce MEPIN, a scalable machine-learning method for efficiently predicting MEPs from reactant…

Chemical Physics · Physics 2026-02-18 Juno Nam , Miguel Steiner , Max Misterka , Soojung Yang , Avni Singhal , Rafael Gómez-Bombarelli

Explicit-electron force fields introduce electrons or electron pairs as semi-classical particles in force fields or empirical potentials, which are suitable for molecular dynamics simulations. Even though semi-classical electrons are a…

Chemical Physics · Physics 2022-05-17 Maarten Cools-Ceuppens , Joni Dambre , Toon Verstraelen

In high energy density physics (HEDP) and inertial confinement fusion (ICF), predictive modeling is complicated by uncertainty in parameters that characterize various aspects of the modeled system, such as those characterizing material…

Machine-learning potentials (MLPs) have become important tools for modern molecular simulations. However, developing models that simultaneously achieve high accuracy and high computational efficiency remains a significant challenge. In this…

Chemical Physics · Physics 2026-02-17 Xinze Li , Ruitao Ma , Chen Qu , Dong H. Zhang , Qi Yu

Machine learning (ML) can be used to construct surrogate models for the fast prediction of a property of interest. ML can thus be applied to chemical projects, where the usual experimentation or calculation techniques can take hours or days…

Fast and accurate simulation of complex chemical systems in environments such as solutions is a long standing challenge in theoretical chemistry. In recent years, machine learning has extended the boundaries of quantum chemistry by…

Chemical Physics · Physics 2020-11-05 Michael Gastegger , Kristof T. Schütt , Klaus-Robert Müller