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Prostate cancer (PCa) is one of the most common cancers in men around the world. The most accurate method to evaluate lesion levels of PCa is microscopic inspection of stained biopsy tissue and estimate the Gleason score of tissue…

The problem of recognizing various types of tissues present in multi-gigapixel histology images is an important fundamental pre-requisite for downstream analysis of the tumor microenvironment in a bottom-up analysis paradigm for…

Deep learning-based melanoma classification with dermoscopic images has recently shown great potential in automatic early-stage melanoma diagnosis. However, limited by the significant data imbalance and obvious extraneous artifacts, i.e.,…

Semantic segmentation involves assigning a specific category to each pixel in an image. While Vision Transformer-based models have made significant progress, current semantic segmentation methods often struggle with precise predictions in…

Transformer models have consistently achieved remarkable results in various domains such as natural language processing and computer vision. However, despite ongoing research efforts to better understand these models, the field still lacks…

The manifold hypothesis posits that high-dimensional data often lies on a lower-dimensional manifold and that utilizing this manifold as the target space yields more efficient representations. While numerous traditional manifold-based…

Melanoma is one of the ten most common cancers in the US. Early detection is crucial for survival, but often the cancer is diagnosed in the fatal stage. Deep learning has the potential to improve cancer detection rates, but its…

Advanced representation learning techniques require reliable and general evaluation methods. Recently, several algorithms based on the common idea of geometric and topological analysis of a manifold approximated from the learned data…

Medical imaging is a cornerstone of therapy and diagnosis in modern medicine. However, the choice of imaging modality for a particular theranostic task typically involves trade-offs between the feasibility of using a particular modality…

Histopathological images are widely used for the analysis of diseased (tumor) tissues and patient treatment selection. While the majority of microscopy image processing was previously done manually by pathologists, recent advances in…

In numerous studies, deep learning algorithms have proven their potential for the analysis of histopathology images, for example, for revealing the subtypes of tumors or the primary origin of metastases. These models require large datasets…

Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of…

The inapplicability of amino acid covariation methods to small protein families has limited their use for structural annotation of whole genomes. Recently, deep learning has shown promise in allowing accurate residue-residue contact…

Transcriptional profiling on microarrays to obtain gene expressions has been used to facilitate cancer diagnosis. We propose a deep generative machine learning architecture (called DeepCancer) that learn features from unlabeled microarray…

In many scenarios, especially biomedical applications, the correct delineation of complex fine-scaled structures such as neurons, tissues, and vessels is critical for downstream analysis. Despite the strong predictive power of deep learning…

Analyzing large volumes of high-dimensional data requires dimensionality reduction: finding meaningful low-dimensional structures hidden in their high-dimensional observations. Such practice is needed in atomistic simulations of complex…

Deep learning (DL)-based tomographic SAR imaging algorithms are gradually being studied. Typically, they use an unfolding network to mimic the iterative calculation of the classical compressive sensing (CS)-based methods and process each…

Malignant melanoma is the deadliest form of skin cancer and, in recent years, is rapidly growing in terms of the incidence worldwide rate. The most effective approach to targeted treatment is early diagnosis. Deep learning algorithms,…

As the application of deep learning in dermatology continues to grow, the recognition of melanoma has garnered significant attention, demonstrating potential for improving diagnostic accuracy. Despite advancements in image classification…

Recent advances in cancer research largely rely on new developments in microscopic or molecular profiling techniques offering high level of detail with respect to either spatial or molecular features, but usually not both. Here, we present…