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Nuclei classification provides valuable information for histopathology image analysis. However, the large variations in the appearance of different nuclei types cause difficulties in identifying nuclei. Most neural network based methods are…

Computer Vision and Pattern Recognition · Computer Science 2023-02-23 Wei Lou , Xiang Wan , Guanbin Li , Xiaoying Lou , Chenghang Li , Feng Gao , Haofeng Li

Scarcity of labeled histopathology data limits the applicability of deep learning methods to under-profiled cancer types and labels. Transfer learning allows researchers to overcome the limitations of small datasets by pre-training machine…

Computer Vision and Pattern Recognition · Computer Science 2022-04-21 Anna Yeaton , Rahul G. Krishnan , Rebecca Mieloszyk , David Alvarez-Melis , Grace Huynh

Pathology deals with the practice of discovering the reasons for disease by analyzing the body samples. The most used way in this field, is to use histology which is basically studying and viewing microscopic structures of cell and tissues.…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Virender Ranga , Shivam Gupta , Priyansh Agrawal , Jyoti Meena

Accurate classification of breast cancer histopathology images is pivotal for early oncological diagnosis and therapeutic intervention.However, conventional deep learning architectures often encounter performance degradation under limited…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Lin-Guo Gao , Suxing Liu

Deploying deep neural networks for risk-sensitive tasks necessitates an uncertainty estimation mechanism. This paper introduces hierarchical selective classification, extending selective classification to a hierarchical setting. Our…

Machine Learning · Computer Science 2025-01-07 Shani Goren , Ido Galil , Ran El-Yaniv

The rich chemical information from tissue metabolomics provides a powerful means to elaborate tissue physiology or tumor characteristics at cellular and tumor microenvironment levels. However, the process of obtaining such information…

Over the recent years, Graph Neural Networks have become increasingly popular in network analytic and beyond. With that, their architecture noticeable diverges from the classical multi-layered hierarchical organization of the traditional…

Machine Learning · Computer Science 2021-05-17 Stanislav Sobolevsky

Many atlases used for brain parcellation are hierarchically organised, progressively dividing the brain into smaller sub-regions. However, state-of-the-art parcellation methods tend to ignore this structure and treat labels as if they are…

Computer Vision and Pattern Recognition · Computer Science 2020-09-17 Mark S. Graham , Carole H. Sudre , Thomas Varsavsky , Petru-Daniel Tudosiu , Parashkev Nachev , Sebastien Ourselin , M. Jorge Cardoso

We introduce HiT, a novel hierarchical neural field representation for 3D shapes that learns general hierarchies in a coarse-to-fine manner across different shape categories in an unsupervised setting. Our key contribution is a hierarchical…

Computer Vision and Pattern Recognition · Computer Science 2026-01-30 Aditya Vora , Lily Goli , Andrea Tagliasacchi , Hao Zhang

Accurate and unbiased examinations of skin lesions are critical for the early diagnosis and treatment of skin diseases. Visual features of skin lesions vary significantly because the images are collected from patients with different lesion…

Image and Video Processing · Electrical Eng. & Systems 2025-02-20 Wei Dai , Rui Liu , Tianyi Wu , Min Wang , Jianqin Yin , Jun Liu

Explainability of deep learning methods is imperative to facilitate their clinical adoption in digital pathology. However, popular deep learning methods and explainability techniques (explainers) based on pixel-wise processing disregard…

To enhance the precision of cancer prognosis, recent research has increasingly focused on multimodal survival methods by integrating genomic data and histology images. However, current approaches overlook the fact that the proteome serves…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Junjie Zhou , Bao Xue , Meiling Wang , Wei Shao , Daoqiang Zhang

Usual relations between entities could be captured using graphs; but those of a higher-order -- more so between two different types of entities (which we term "left" and "right") -- calls for a "bipartite hypergraph". For example, given a…

Machine Learning · Computer Science 2021-11-02 Govind Sharma , Swyam Prakash Singh , V. Susheela Devi , M. Narasimha Murty

The identification of drug-target binding affinity (DTA) has attracted increasing attention in the drug discovery process due to the more specific interpretation than binary interaction prediction. Recently, numerous deep learning-based…

Machine Learning · Computer Science 2022-03-23 Zhaoyang Chu , Shichao Liu , Wen Zhang

Link Prediction on Hyper-relational Knowledge Graphs (HKG) is a worthwhile endeavor. HKG consists of hyper-relational facts (H-Facts), composed of a main triple and several auxiliary attribute-value qualifiers, which can effectively…

Artificial Intelligence · Computer Science 2023-10-17 Haoran Luo , Haihong E , Yuhao Yang , Yikai Guo , Mingzhi Sun , Tianyu Yao , Zichen Tang , Kaiyang Wan , Meina Song , Wei Lin

Protein subcellular localization is an important factor in normal cellular processes and disease. While many protein localization resources treat it as static, protein localization is dynamic and heavily influenced by biological context.…

Molecular Networks · Quantitative Biology 2022-12-13 Chris S. Magnano , Anthony Gitter

In a world abundant with diverse data arising from complex acquisition techniques, there is a growing need for new data analysis methods. In this paper we focus on high-dimensional data that are organized into several hierarchical datasets.…

Machine Learning · Computer Science 2021-04-06 Lior Aloni , Omer Bobrowski , Ronen Talmon

This paper explores the application of Human-in-the-Loop (HITL) strategies in training machine learning models in the medical domain. In this case a doctor-in-the-loop approach is proposed to leverage human expertise in dealing with large…

Computer Vision and Pattern Recognition · Computer Science 2024-04-01 David Vázquez-Lema , Eduardo Mosqueira-Rey , Elena Hernández-Pereira , Carlos Fernández-Lozano , Fernando Seara-Romera , Jorge Pombo-Otero

Histology method is vital in the diagnosis and prognosis of cancers and many other diseases. For the analysis of histopathological images, we need to detect and segment all gland structures. These images are very challenging, and the task…

Image and Video Processing · Electrical Eng. & Systems 2019-11-05 Safiye Rezaei , Ali Emami , Nader Karimi , Shadrokh Samavi

Serous borderline ovarian tumor (SBOT) and high-grade serous ovarian cancer (HGSOC) are two distinct subtypes of epithelial ovarian tumors, with markedly different biologic background, behavior, prognosis, and treatment. However, the…

Image and Video Processing · Electrical Eng. & Systems 2020-08-31 Jun Jiang , Burak Tekin , Ruifeng Guo , Hongfang Liu , Yajue Huang , Chen Wang