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Interpretable machine learning models offer understandable reasoning behind their decision-making process, though they may not always match the performance of their black-box counterparts. This trade-off between interpretability and model…

Artificial Intelligence · Computer Science 2025-03-12 Pranjal Atrey , Michael P. Brundage , Min Wu , Sanghamitra Dutta

When we deploy machine learning models in high-stakes medical settings, we must ensure these models make accurate predictions that are consistent with known medical science. Inherently interpretable networks address this need by explaining…

Computer Vision and Pattern Recognition · Computer Science 2021-10-06 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

With the increasing availability of diverse data types, particularly images and time series data from medical experiments, there is a growing demand for techniques designed to combine various modalities of data effectively. Our motivation…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Ali Rasekh , Reza Heidari , Amir Hosein Haji Mohammad Rezaie , Parsa Sharifi Sedeh , Zahra Ahmadi , Prasenjit Mitra , Wolfgang Nejdl

Machine learning is frequently used in affective computing, but presents challenges due the opacity of state-of-the-art machine learning methods. Because of the impact affective machine learning systems may have on an individual's life, it…

Machine Learning · Computer Science 2025-10-07 David S. Johnson , Olya Hakobyan , Hanna Drimalla

Interpretability remains a key challenge for deploying large language models (LLMs) in clinical settings such as Alzheimer's disease progression diagnosis, where early and trustworthy predictions are essential. Existing attribution methods…

The black-box nature of machine learning models hinders the deployment of some high-accuracy models in medical diagnosis. It is risky to put one's life in the hands of models that medical researchers do not fully understand. However,…

Machine Learning · Computer Science 2021-10-22 Han Wu , Wenjie Ruan , Jiangtao Wang , Dingchang Zheng , Bei Liu , Yayuan Gen , Xiangfei Chai , Jian Chen , Kunwei Li , Shaolin Li , Sumi Helal

Sepsis is a leading cause of mortality in intensive care units (ICUs), representing a substantial medical challenge. The complexity of analyzing diverse vital signs to predict sepsis further aggravates this issue. While deep learning…

Machine Learning · Computer Science 2024-05-24 Yuwei Liu , Chen Dan , Anubhav Bhatti , Bingjie Shen , Divij Gupta , Suraj Parmar , San Lee

Intensive care unit (ICU) is a crucial hospital department that handles life-threatening cases. Nowadays machine learning (ML) is being leveraged in healthcare ubiquitously. In recent years, management of ICU became one of the most…

Machine Learning · Computer Science 2025-05-26 Alexander Gabitashvili , Philipp Kellmeyer

Recent developments in single-cell omics technologies have enabled the quantification of molecular profiles in individual cells at an unparalleled resolution. Deep learning, a rapidly evolving sub-field of machine learning, has instilled a…

Genomics · Quantitative Biology 2024-01-17 Manoj M Wagle , Siqu Long , Carissa Chen , Chunlei Liu , Pengyi Yang

Deep learning is increasingly being used in high-stake decision making applications that affect individual lives. However, deep learning models might exhibit algorithmic discrimination behaviors with respect to protected groups, potentially…

Machine Learning · Computer Science 2020-03-20 Mengnan Du , Fan Yang , Na Zou , Xia Hu

In-hospital mortality (IHM) prediction for ICU patients is critical for timely interventions and efficient resource allocation. While structured physiological data provides quantitative insights, clinical notes offer unstructured,…

Computation and Language · Computer Science 2024-11-27 Harshavardhan Battula , Jiacheng Liu , Jaideep Srivastava

Reinforcement Learning in Healthcare is typically concerned with narrow self-contained tasks such as sepsis prediction or anesthesia control. However, previous research has demonstrated the potential of generalist models (the prime example…

Machine Learning · Computer Science 2024-05-28 Vadim Liventsev , Tobias Fritz

Interpretability is often an essential requirement in medical imaging. Advanced deep learning methods are required to address this need for explainability and high performance. In this work, we investigate whether additional information…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Luisa Gallee , Meinrad Beer , Michael Goetz

Mechanistic interpretability is an emerging diagnostic approach for neural models that has gained traction in broader natural language processing domains. This paradigm aims to provide attribution to components of neural systems where…

Information Retrieval · Computer Science 2025-01-20 Andrew Parry , Catherine Chen , Carsten Eickhoff , Sean MacAvaney

This study investigated the performance, explainability, and robustness of deployed artificial intelligence (AI) models in predicting mortality during the COVID-19 pandemic and beyond. The first study of its kind, we found that Bayesian…

Machine Learning · Computer Science 2023-11-30 Jacob R. Epifano , Stephen Glass , Ravi P. Ramachandran , Sharad Patel , Aaron J. Masino , Ghulam Rasool

Accurate staging of liver fibrosis from magnetic resonance imaging (MRI) is crucial in clinical practice. While conventional methods often focus on a specific sub-region, multi-view learning captures more information by analyzing multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Yuanye Liu , Zheyao Gao , Nannan Shi , Fuping Wu , Yuxin Shi , Qingchao Chen , Xiahai Zhuang

The visual representation of a pre-trained model prioritizes the classifiability on downstream tasks, while the widespread applications for pre-trained visual models have posed new requirements for representation interpretability. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-29 Shufan Shen , Zhaobo Qi , Junshu Sun , Qingming Huang , Qi Tian , Shuhui Wang

Interpretable machine learning (IML) becomes increasingly important in highly regulated industry sectors related to the health and safety or fundamental rights of human beings. In general, the inherently IML models should be adopted because…

Machine Learning · Computer Science 2021-11-03 Agus Sudjianto , Aijun Zhang

Deep learning models have achieved state-of-the-art performance in many classification tasks. However, most of them cannot provide an interpretation for their classification results. Machine learning models that are interpretable are…

Machine Learning · Computer Science 2021-11-04 Miles Q. Li , Benjamin C. M. Fung , Adel Abusitta

While multimodal survival prediction models are increasingly more accurate, their complexity often reduces interpretability, limiting insight into how different data sources influence predictions. To address this, we introduce DIMAFx, an…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Aniek Eijpe , Soufyan Lakbir , Melis Erdal Cesur , Sara P. Oliveira , Angelos Chatzimparmpas , Sanne Abeln , Wilson Silva
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