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The recent boom of large language models (LLMs) has re-ignited the hope that artificial intelligence (AI) systems could aid medical diagnosis. Yet despite dazzling benchmark scores, LLM assistants have yet to deliver measurable improvements…

Artificial Intelligence · Computer Science 2025-07-03 Matthew JY Kang , Wenli Yang , Monica R Roberts , Byeong Ho Kang , Charles B Malpas

An important limitation to the development of AI-based solutions for In Vitro Fertilization (IVF) is the black-box nature of most state-of-the-art models, due to the complexity of deep learning architectures, which raises potential bias and…

Computer Vision and Pattern Recognition · Computer Science 2022-05-16 Tristan Gomez , Thomas Fréour , Harold Mouchère

While Large Language Models (LLMs) have achieved strong performance across many NLP tasks, their opaque internal mechanisms hinder trustworthiness and safe deployment. Existing surveys in explainable AI largely focus on post-hoc explanation…

Computation and Language · Computer Science 2026-04-21 Yutong Gao , Qinglin Meng , Yuan Zhou , Liangming Pan

Real-world problems are often dependent on multiple data modalities, making multimodal fusion essential for leveraging diverse information sources. In high-stakes domains, such as in healthcare, understanding how each modality contributes…

Neural and Evolutionary Computing · Computer Science 2025-05-19 Mafalda Malafaia , Thalea Schlender , Tanja Alderliesten , Peter A. N. Bosman

Recently, deep learning has been advancing the state of the art in artificial intelligence to a new level, and humans rely on artificial intelligence techniques more than ever. However, even with such unprecedented advancements, the lack of…

Human-Computer Interaction · Computer Science 2018-04-10 Jaegul Choo , Shixia Liu

Understanding AI systems' inner workings is critical for ensuring value alignment and safety. This review explores mechanistic interpretability: reverse engineering the computational mechanisms and representations learned by neural networks…

Artificial Intelligence · Computer Science 2024-08-27 Leonard Bereska , Efstratios Gavves

Across various sectors such as healthcare, criminal justice, national security, finance, and technology, large-scale machine learning (ML) and artificial intelligence (AI) systems are being deployed to make critical data-driven decisions.…

Machine Learning · Statistics 2023-10-09 Camille Olivia Little , Debolina Halder Lina , Genevera I. Allen

Interpretation methods to reveal the internal reasoning processes behind machine learning models have attracted increasing attention in recent years. To quantify the extent to which the identified interpretations truly reflect the intrinsic…

Computation and Language · Computer Science 2022-04-13 Chun Sik Chan , Huanqi Kong , Guanqing Liang

Fairness is a critical concern in deep learning, especially in healthcare, where these models influence diagnoses and treatment decisions. Although fairness has been investigated in the vision-only domain, the fairness of medical…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Yan Luo , Min Shi , Muhammad Osama Khan , Muhammad Muneeb Afzal , Hao Huang , Shuaihang Yuan , Yu Tian , Luo Song , Ava Kouhana , Tobias Elze , Yi Fang , Mengyu Wang

With the current ongoing debate about fairness, explainability and transparency of machine learning models, their application in high-impact clinical decision-making systems must be scrutinized. We consider a real-life example of risk…

Machine Learning · Computer Science 2020-11-13 Sandhya Tripathi , Bradley A. Fritz , Mohamed Abdelhack , Michael S. Avidan , Yixin Chen , Christopher R. King

Understanding why machine learning models behave the way they do empowers both system designers and end-users in many ways: in model selection, feature engineering, in order to trust and act upon the predictions, and in more intuitive user…

Machine Learning · Statistics 2016-06-20 Marco Tulio Ribeiro , Sameer Singh , Carlos Guestrin

Social media platforms provide valuable insights into mental health trends by capturing user-generated discussions on conditions such as depression, anxiety, and suicidal ideation. Machine learning (ML) and deep learning (DL) models have…

Computation and Language · Computer Science 2025-04-28 Zhanyi Ding , Zhongyan Wang , Yeyubei Zhang , Yuchen Cao , Yunchong Liu , Xiaorui Shen , Yexin Tian , Jianglai Dai

The evaluation of fairness models in Machine Learning involves complex challenges, such as defining appropriate metrics, balancing trade-offs between utility and fairness, and there are still gaps in this stage. This work presents a novel…

Machine Learning · Computer Science 2026-03-03 Gökhan Özbulak , Oscar Jimenez-del-Toro , Maíra Fatoretto , Lilian Berton , André Anjos

Background: Sepsis-Associated Acute Kidney Injury (SA-AKI) leads to high mortality in intensive care. This study develops machine learning models using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database to predict…

Machine Learning · Computer Science 2025-05-20 Shuheng Chen , Junyi Fan , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Personalized medicine remains a major challenge for scientists. The rapid growth of Machine learning and Deep learning has made them a feasible al- ternative for predicting the most appropriate therapy for individual patients. However, the…

Machine Learning · Computer Science 2025-06-10 Antonio Jesús Banegas-Luna , Horacio Pérez-Sánchez

Interpretability is the study of explaining models in understandable terms to humans. At present, interpretability is divided into two paradigms: the intrinsic paradigm, which believes that only models designed to be explained can be…

Machine Learning · Computer Science 2024-11-14 Andreas Madsen , Himabindu Lakkaraju , Siva Reddy , Sarath Chandar

A wide variety of model explanation approaches have been proposed in recent years, all guided by very different rationales and heuristics. In this paper, we take a new route and cast interpretability as a statistical inference problem. We…

Machine Learning · Computer Science 2024-01-01 Hugo Henri Joseph Senetaire , Damien Garreau , Jes Frellsen , Pierre-Alexandre Mattei

Multimodal sentiment analysis is an important area for understanding the user's internal states. Deep learning methods were effective, but the problem of poor interpretability has gradually gained attention. Previous works have attempted to…

Computation and Language · Computer Science 2023-05-15 Sixia Li , Shogo Okada

Machine-learning models have demonstrated great success in learning complex patterns that enable them to make predictions about unobserved data. In addition to using models for prediction, the ability to interpret what a model has learned…

Machine Learning · Statistics 2019-11-15 W. James Murdoch , Chandan Singh , Karl Kumbier , Reza Abbasi-Asl , Bin Yu

Machine learning models have had discernible achievements in a myriad of applications. However, most of these models are black-boxes, and it is obscure how the decisions are made by them. This makes the models unreliable and untrustworthy.…

Machine Learning · Computer Science 2020-03-23 Raha Moraffah , Mansooreh Karami , Ruocheng Guo , Adrienne Raglin , Huan Liu
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