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Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes. Gene products such as proteins seldom…
This work examines the conformational ensemble involved in $\beta$-hairpin folding by means of advanced molecular dynamics simulations and dimensionality reduction. A fully atomistic description of the protein and the surrounding solvent…
Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single…
Hematoxylin and Eosin stained histopathology image analysis is essential for the diagnosis and study of complicated diseases such as cancer. Existing state-of-the-art approaches demand extensive amount of supervised training data from…
$\alpha$-Sn exhibits a rich topological phase diagram, yet experimental methods to tune and distinguish these phases remain limited. Here, we investigated the helicity-dependent photocurrent (HDPC) in $\alpha$-Sn films of varying thickness…
Publicly available collections of drug-like molecules have grown to comprise 10s of billions of possibilities in recent history due to advances in chemical synthesis. Traditional methods for identifying "hit" molecules from a large…
Motivated by recent transport experiments and proposed atomic-scale semiconductor devices, we present measurements that extend the reach of scanned-probe methods to discern the properties of individual dopants tens of nanometers below the…
We consider two minimal mathematical models for cancer dynamics and self-adaptation. We aim to capture the interplay between the rapid progression of cancer growth and the possibility to leverage and enhance self-adaptive defense mechanisms…
Aberrantly regulated cell motility is a hallmark of cancer cells. A hybrid agent-based model has been developed to investigate the synergistic and antagonistic cell motility-impacting effects of three microenvironment variables…
Drug combinations play an important role in therapeutics due to its better efficacy and reduced toxicity. Recent approaches have applied machine learning to identify synergistic combinations for cancer, but they are not applicable to new…
Discriminating between Parkinson's Disease (PD) and Progressive Supranuclear Palsy (PSP) is difficult due to overlapping symptoms, especially early on. Saccades (rapid conjugate eye movements between fixation points) are affected by both…
Monolayer molybdenum disulfide (MoS2) has a honeycomb crystal structure. We consider the triangular sublattice of molybdenum atoms and introduce a simple tight-binding Hamiltonian for studying the phase transition and topological…
The electronic properties of hybrid organic-inorganic semiconductor interfaces depend strongly on the alignment of the electronic carrier levels in the organic/inorganic components. In the present work, we address this energy level…
Particles trapped in the evanescent field of an ultrathin optical fibre inter-act over very long distances via multiple scattering of the fibre-guided fields. In ultrathin fibres that support higher order modes, these interac-tions are…
Vascular adhesion of circulating tumor cells (CTCs) is a key step in cancer spreading. If inflammation is recognized to favor the formation of vascular metastatic niches, little is known about the contribution of blood rheology to CTC…
In chemical reactions, the interplay between coherent evolution and dissipation is central to determining key properties such as the rate and yield. Of particular interest are cases where two potential energy surfaces cross at features…
The reaction mechanism of the central collisions and peripheral collisions for $^{112,124}Sn+^{112,124}Sn$ at $E/A=50MeV$ is investigated within the framework of the Improved Quantum Molecular Dynamics model. The results show that…
In polymer science, cross-linking of polymer chains yields a substantially modified system compared to the one-dimensional constituent chains, due to the increase of dimensionality and effective seeding by defects (cross-linking sites).…
Signal transduction within biological cells is governed by networks of interacting proteins. Communication between these proteins is mediated by signaling molecules which bind to receptors and induce stochastic transitions between different…
Understanding hadronic interactions is crucial for investigating the properties of unstable hadrons, since measuring physical quantities for unstable hadrons including the resonance mass and decay width requires simultaneous calculations of…