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Cell motility is one of the most fundamental phenomena underlying biological processes that maintain living organisms alive. Here we introduce a simple model to describe the motility of cells which include not only time-correlated internal…

Biological Physics · Physics 2022-07-13 T. N. Azevedo , L. G. Rizzi

During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases,…

Biological Physics · Physics 2016-07-07 Fabian Spill , Vivi Andasari , Michael Mak , Roger D. Kamm , Muhammad H. Zaman

In this work we have characterized the phase behaviour and the dynamics of bidimensional mixtures of active and passive Brownian particles. We have evaluated state diagrams at several concentrations of the passive components finding that,…

Soft Condensed Matter · Physics 2025-11-12 Diego Rogel Rodriguez , Francisco Alarcon , Raul Martinez , Jorge Ramirez , Chantal Valeriani

Active matter comprises individually driven units that convert locally stored energy into mechanical motion. Interactions between driven units lead to a variety of non-equilibrium collective phenomena in active matter. One of such phenomena…

Soft Condensed Matter · Physics 2021-06-15 Mingji Huang , Wensi Hu , Siyuan Yang , Quan-Xing Liu , H. P. Zhang

We study a generic model for the polarisation and motility of self-propelled soft objects, biological cells or biomimetic systems, interacting with a viscous substrate. The active forces generated by the cell on the substrate are modelled…

Soft Condensed Matter · Physics 2015-06-23 M. Leoni , P. Sens

We develop an agent-based model of the motion and pattern formation of vesicles. These intracellular particles can be found in four different modes of (undirected and directed) motion and can fuse with other vesicles. While the size of…

Subcellular Processes · Quantitative Biology 2011-09-19 Mirko Birbaumer , Frank Schweitzer

We study the dynamics of proliferating cell collectives whose microscopic constituents' growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a growing collective show the emergence of concentric-ring…

Biological Physics · Physics 2024-05-17 Scott Weady , Bryce Palmer , Adam Lamson , Taeyoon Kim , Reza Farhadifar , Michael J. Shelley

Self-activation coupled to a transport mechanism results in traveling waves that describe polymerization reactions, forest fires, tumor growth, and even the spread of epidemics. Diffusion is a simple and commonly used model of particle…

Statistical Mechanics · Physics 2020-07-06 Keisuke Ishihara , Ashish B. George , Ryan Cornelius , Kirill S. Korolev

We propose a neural network model of multi-neuron interacting system that simulates neurons to interact each other through the surroundings of neuronal cell bodies. We physically model the neuronal cell surroundings, include the dendrites,…

Neurons and Cognition · Quantitative Biology 2021-07-05 Yu-Juan Sun , Wei-Min Zhang

Swimmers and self-propelled particles are physical models for the collective behaviour and motility of a wide variety of living systems, such as bacteria colonies, bird flocks and fish schools. Such artificial active materials are amenable…

Biological tissues are active materials whose non-equilibrium dynamics emerge from distinct cellular force-generating mechanisms. Using a two-dimensional active foam model, we compare the effects of traction forces and junctional tension…

Biological Physics · Physics 2026-04-14 Alessandro Rizzi , Sangwoo Kim

We propose a three dimensional mechanical model of embryonic tissue dynamics. Mechanically coupled adherent cells are represented as particles interconnected with elastic beams which can exert non-central forces and torques. Tissue…

Biological Physics · Physics 2015-06-22 Andras Czirok , Dona Greta Isai

The dynamics of a packages diffusion process within a selforganized network is analytically studied by means of an extended $f$% -spin facilitated kinetic Ising model (Fredrickson-Andersen model) using a Fock-space representation for the…

Statistical Mechanics · Physics 2009-11-07 C. Pigorsch , S. Trimper

Motivated by various recent experimental findings, we propose a dynamical model of intermittently self-propelled particles: active particles that recurrently switch between two modes of motion, namely an active run-state and a turn state,…

Soft Condensed Matter · Physics 2025-10-30 Agniva Datta , Carsten Beta , Robert Großmann

Aggregation and fragmentation of single molecules in the cell environment lead to a spectrum of diffusivities and to statistical laws of movement very different from typical Brownian motion. Current models of intracellular transport do not…

Statistical Mechanics · Physics 2020-07-08 M. Hidalgo-Soria , E. Barkai

Living cells exhibit multi-mode transport that switches between an active, self-propelled motion and a seemingly passive, random motion. Cellular decision-making over transport mode switching is a stochastic process that depends on the…

Biological Physics · Physics 2020-10-28 Seungsoo Hahn , Sanggeun Song , Dae Hyun Kim , Gil-Suk Yang , Kang Taek Lee , Jaeyoung Sung

Systems of active particles can show a large variety of collective behavior. In theory, two aspects determine the collective behavior: the model at the particle level and the parameter regime. While many studies consider a single model and…

Soft Condensed Matter · Physics 2025-11-17 Colin-Marius Koch , Michael Wilczek

Collective rotations are common in active matter, enhancing cohesion, transport, and mixing. They are typically attributed to chiral non-reciprocal dynamics due to intrinsic particle chirality, torque-generating interactions among units, or…

Soft Condensed Matter · Physics 2026-04-20 Maks Pečnik Bambič , Nuno A. M. Araújo , Giorgio Volpe

Recent advances in high-resolution experimental methods have highlighted the significance of cell signal pathway crosstalk and localised signalling activity in the development and disease of numerous biological systems. The investigation of…

Dynamical Systems · Mathematics 2022-09-19 Joshua W. Moore , Trevor C. Dale , Thomas E. Woolley

We study the dynamics of circular active particles (AP) on a two dimensional periodic undulated surface. Each particle has an internal energy mechanism which is modeled by an active friction force and it is controlled by an activity…

Soft Condensed Matter · Physics 2021-03-04 Vivek Semwal , Shambhavi Dikshit , Shradha Mishra