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The coupling of the internal mechanisms of cell polarization to cell shape deformations and subsequent cell crawling poses many interdisciplinary scientific challenges. Several mathematical approaches have been proposed to model the…

Cell Behavior · Quantitative Biology 2023-11-08 Eduardo Moreno , Robert Großmann , Carsten Beta , Sergio Alonso

In the presented work we study, by means of numerical simulations, the behaviour of a suspension of active ring polymers in the bulk and under lateral confinement. When changing the separation between the confining planes and the polymers'…

Soft Condensed Matter · Physics 2023-07-31 Juan Pablo Miranda-López , Emanuele Locatelli , Chantal Valeriani

Active particle systems of interacting self-propelled particles offer a versatile framework for modeling complex systems. When employed to describe aspects of animal behavior, the complexity of animal movement and decision-making often…

Biological Physics · Physics 2025-01-09 Amir Haluts , Dan Gorbonos , Nir S. Gov

The processes taking place inside the living cell are now understood to the point where predictive computational models can be used to gain detailed understanding of important biological phenomena. A key challenge is to extrapolate this…

Tissues and Organs · Quantitative Biology 2018-10-26 Stefan Engblom Daniel B. Wilson , Ruth E. Baker

Active matter physics has been developed with various types of self-propelled particles, including those with polar and bipolar motility and beyond. However, the bipolar motions experimentally realized so far have been either random along…

Soft Condensed Matter · Physics 2022-07-28 Airi N. Kato , Kazumasa A. Takeuchi , Masaki Sano

Active particles contain internal degrees of freedom with the ability to take in and dissipate energy and, in the process, execute systematic movement. Examples include all living organisms and their motile constituents such as molecular…

Soft Condensed Matter · Physics 2015-05-18 Sriram Ramaswamy

Collective and directed motility or swarming is an emergent phenomenon displayed by many self-organized assemblies of active biological matter such as clusters of embryonic cells during tissue development, cancerous cells during tumor…

Biological Physics · Physics 2016-04-05 Katherine Copenhagen , Ajay Gopinathan

The organization of cells within tissues plays a vital role in various biological processes, including development and morphogenesis. As a result, understanding how cells self-organize in tissues has been an active area of research. In our…

Soft Condensed Matter · Physics 2023-10-09 Kanaya Malakar , Rafael I. Rubenstein , Dapeng Bi , Bulbul Chakraborty

Escape of active agents from metastable states is of great interest in statistical and biological physics. In this study, we investigate the escape of a flexible active ring, composed of active Brownian particles, from a flat attractive…

Soft Condensed Matter · Physics 2024-08-21 Bin Tang , Jin-cheng Gao , Kang Chen , Tian Hui Zhang , Wen-de Tian

The diffusion of active microscopic organisms in complex environments plays an important role in a wide range of biological phenomena from cell colony growth to single organism transport. Here, we investigate theoretically and…

Fluid Dynamics · Physics 2018-01-16 Juan L. Aragones , Shahrzad Yazdi , Alfredo Alexander-Katz

Collective motion of cells is common in many physiological processes, including tissue development, repair, and tumor formation. Recent experiments have shown that certain malignant cancer cells form clusters in a chemoattractant gradient,…

Biological Physics · Physics 2017-05-02 Katherine Copenhagen , Gema Malet-Engra , Weimiao Yu , Giorgio Scita , Nir Gov , Ajay Gopinathan

Pulsatory activity patterns, driven by mechanochemical feedback, are prevalent in many biological systems. Here we present a theoretical framework to elucidate the mechanical origin and regulation of pulsatile activity patterns within…

Biological Physics · Physics 2023-10-10 Fernanda Pérez-Verdugo , Samuel Banks , Shiladitya Banerjee

Several cellular activities, such as directed cell migration, are coordinated by an intricate network of biochemical reactions which lead to a polarised state of the cell, in which cellular symmetry is broken, causing the cell to have a…

Cell Behavior · Quantitative Biology 2018-09-13 Davide Cusseddu , Leah Edelstein-Keshet , John A. Mackenzie , Stéphanie Portet , Anotida Madzvamuse

Motivated by the formation of ring-like filament structures in the cortex of plant and animal cells, we study the dynamics of a two-dimensional layer of cytoskeletal filaments and motor proteins near a surface by a general continuum theory.…

Subcellular Processes · Quantitative Biology 2009-11-11 Alexander Zumdieck , Marco Cosentino Lagomarsino , Catalin Tanase , Karsten Kruse , Bela Mulder , Marileen Dogterom , Frank J"ulicher

Tracking experiments in dense biological tissues reveal a diversity of sources f or local energy injection at the cell scale. The effect of cell motility has been largely studied, but much less is known abo ut the effect of the observed…

Soft Condensed Matter · Physics 2017-11-29 Elsen Tjhung , Ludovic Berthier

A collection of rings made of active Brownian particles (ABPs) for different packing fractions and activities is investigated using computer simulations. We show that active rings display an emergent dynamic clustering instead of the…

Soft Condensed Matter · Physics 2024-02-27 Ligesh Theeyancheri , Subhasish Chaki , Tapomoy Bhattacharjee , Rajarshi Chakrabarti

The Active Brownian Particle (ABP) model exemplifies a wide class of active matter particles. In this work, we demonstrate how this model can be cast into a field theory in both two and three dimensions. Our aim is manifold: we wish both to…

Soft Condensed Matter · Physics 2022-12-26 Ziluo Zhang , Lili Fehértói-Nagy , Maria Polackova , Gunnar Pruessner

Active particles may happen to be confined in channels so narrow that they cannot overtake each other (Single File conditions). This interesting situation reveals nontrivial physical features as a consequence of the strong inter-particle…

Statistical Mechanics · Physics 2015-06-19 Emanuele Locatelli , Fulvio Baldovin , Enzo Orlandini , Matteo Pierno

Nowadays, multiscale modelling is recognized as the most suitable way to study biological processes. Indeed, almost every phenomenon in nature exhibits a multiscale behaviour, i.e., it is the outcome of interactions that occur at different…

Formal Languages and Automata Theory · Computer Science 2011-08-18 Federico Buti , Massimo Callisto De Donato , Flavio Corradini , Emanuela Merelli , Luca Tesei

This work concerns a many-body deterministic model that displays life-like properties as emergence, complexity, self-organization, spontaneous compartmentalization, and self-regulation. The model portraits the dynamics of an ensemble of…

Adaptation and Self-Organizing Systems · Physics 2023-07-11 Alessandro Scirè , Valerio Annovazzi-Lodi