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The HEP community is approaching an era were the excellent performances of the particle accelerators in delivering collision at high rate will force the experiments to record a large amount of information. The growing size of the datasets…

How and where proteins interface with one another can ultimately impact the proteins' functions along with a range of other biological processes. As such, precise computational methods for protein interface prediction (PIP) come highly…

Quantitative Methods · Quantitative Biology 2021-10-08 Alex Morehead , Chen Chen , Ada Sedova , Jianlin Cheng

High-dimensional omics datasets are routinely visualized as heatmaps, where color intensities reveal co-expression patterns and correlations. However, modern omics technologies increasingly generate matrices so large that existing visual…

Genomics · Quantitative Biology 2026-04-21 Osho Rawal , Rex Lu , Edgar Gonzalez-Kozlova , Sacha Gnjatic , Zeynep H. Gümüş

Powerful detectors at modern experimental facilities routinely collect data at multiple GB/s. Online analysis methods are needed to enable the collection of only interesting subsets of such massive data streams, such as by explicitly…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-08-23 Rafael Vescovi , Ryan Chard , Nickolaus Saint , Ben Blaiszik , Jim Pruyne , Tekin Bicer , Alex Lavens , Zhengchun Liu , Michael E. Papka , Suresh Narayanan , Nicholas Schwarz , Kyle Chard , Ian Foster

R has become a cornerstone of scientific and statistical computing due to its extensive package ecosystem, expressive syntax, and strong support for reproducible analysis. However, as data sizes and computational demands grow, native R…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-13 Xiran Zhang , Javier Conejero , Sameh Abdulah , Jorge Ejarque , Ying Sun , Rosa M. Badia , David E. Keyes , Marc G. Genton

Background: The huge quantity of data produced in Biomedical research needs sophisticated algorithmic methodologies for its storage, analysis, and processing. High Performance Computing (HPC) appears as a magic bullet in this challenge.…

Quantitative Methods · Quantitative Biology 2016-10-19 Gianni D'Angelo , Salvatore Rampone

The escalating data volume and complexity resulting from the rapid expansion of artificial intelligence (AI), internet of things (IoT) and 5G/6G mobile networks is creating an urgent need for energy-efficient, scalable computing hardware.…

Hyperparameter optimization (HPO) is a necessary step to ensure the best possible performance of Machine Learning (ML) algorithms. Several methods have been developed to perform HPO; most of these are focused on optimizing one performance…

Machine Learning · Computer Science 2022-11-16 Alejandro Morales-Hernández , Inneke Van Nieuwenhuyse , Sebastian Rojas Gonzalez

Partitioning graphs into blocks of roughly equal size such that few edges run between blocks is a frequently needed operation when processing graphs on a parallel computer. When a topology of a distributed system is known an important task…

Data Structures and Algorithms · Computer Science 2020-01-23 Marcelo Fonseca Faraj , Alexander van der Grinten , Henning Meyerhenke , Jesper Larsson Träff , Christian Schulz

Multinational enterprises conduct global business that has a demand for geo-distributed transactional databases. Existing state-of-the-art databases adopt a sharded master-follower replication architecture. However, the single-master…

Main memory column-stores have proven to be efficient for processing analytical queries. Still, there has been much less work in the context of clusters. Using only a single machine poses several restrictions: Processing power and data…

Databases · Computer Science 2017-09-18 Demian Hespe , Martin Weidner , Jonathan Dees , Peter Sanders

This paper presents SHARP (Supercomputing for High-speed Avoidance and Reactive Planning), a proof-of-concept study demonstrating how high-performance computing (HPC) can enable millisecond-scale responsiveness in robotic control. While…

Understanding the complex behavior of molecular systems is fundamental to fields such as physics, materials science, and biology. Molecular dynamics (MD) simulations are crucial tools for studying atomic-level dynamics. This work focuses on…

Computational Engineering, Finance, and Science · Computer Science 2025-07-16 David Martin , Samuel James Newcome , Markus Mühlhäußer , Manish Kumar Mishra , Fabio Alexander Gratl , Hans-Joachim Bungartz

To overcome the energy and bandwidth limitations of traditional IoT systems, edge computing or information extraction at the sensor node has become popular. However, now it is important to create very low energy information extraction or…

Machine Learning · Computer Science 2019-12-05 Sumon Kumar Bose , Bapi Kar , Mohendra Roy , Pradeep Kumar Gopalakrishnan , Zhang Lei , Aakash Patil , Arindam Basu

Exploratory data analysis tools must respond quickly to a user's questions, so that the answer to one question (e.g. a visualized histogram or fit) can influence the next. In some SQL-based query systems used in industry, even very large…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-11-09 Jim Pivarski , David Lange , Thanat Jatuphattharachat

High-performance computing (HPC) requires resilience techniques such as checkpointing in order to tolerate failures in supercomputers. As the number of nodes and memory in supercomputers keeps on increasing, the size of checkpoint data also…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-06-13 Kai Keller , Leonardo Bautista Gomez

Online analytical processing of queries on datasets in the many-terabyte range is only possible with costly distributed computing systems. To decrease the cost and increase the throughput, systems can leverage accelerators such as GPUs,…

Selectivity estimation remains a critical task in query optimization even after decades of research and industrial development. Optimizers rely on accurate selectivities when generating execution plans. They maintain a large range of…

Databases · Computer Science 2019-01-08 Jun Hyung Shin , Florin Rusu , Alex Suhan

Scientific advancements rely on high-performance computing (HPC) applications that model real-world phenomena through simulations. These applications process vast amounts of data on specialized accelerators (eg., GPUs) using special…

Software Engineering · Computer Science 2025-01-20 Matthew Davis , Aakash Kulkarni , Ziyan Chen , Yunhan Qiao , Christopher Terrazas , Manish Motwani

We propose a novel Parallel Monte Carlo tree search with Batched Simulations (PMBS) algorithm for accelerating long-horizon, episodic robotic planning tasks. Monte Carlo tree search (MCTS) is an effective heuristic search algorithm for…

Robotics · Computer Science 2022-07-15 Baichuan Huang , Abdeslam Boularias , Jingjin Yu