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Two-sample hypothesis testing for network comparison presents many significant challenges, including: leveraging repeated network observations and known node registration, but without requiring them to operate; relaxing strong structural…
Protein motifs are conserved fragments occurred frequently in protein sequences. They have significant functions, such as active site of an enzyme. Search and clustering protein sequence motifs are computational intensive. Most existing…
This paper presents hep-aid, a modular Python library conceived for utilising, implementing, and developing parameter scan algorithms. Originally devised for sample-efficient, multi-objective active search approaches in computationally…
Recently, parallel search engines have been implemented based on scalable distributed file systems such as Google File System. However, we claim that building a massively-parallel search engine using a parallel DBMS can be an attractive…
Subgraph isomorphism, essential for pattern detection in large-scale graphs, faces scalability challenges in attribute-rich property graphs used in neuroscience, systems biology, and social network analysis. Traditional algorithms explore…
The near channel performance of Low Density Parity Check Codes (LDPC) has motivated its wide applications. Iterative decoding of LDPC codes provides significant implementation challenges as the complexity grows with the code size. Recent…
Numerous complex real-world systems, such as those in biological, ecological, and social networks, exhibit higher-order interactions that are often modeled using polynomial dynamical systems or homogeneous polynomial dynamical systems…
An important step in the task of neural network design, such as hyper-parameter optimization (HPO) or neural architecture search (NAS), is the evaluation of a candidate model's performance. Given fixed computational resources, one can…
Metaproteomics has become a crucial omics technology for studying microbiomes. In this area, the Unipept ecosystem, accessible at https://unipept.ugent.be, has emerged as an invaluable resource for analyzing metaproteomic data. It offers…
Latent variable models have accumulated a considerable amount of interest from the industry and academia for their versatility in a wide range of applications. A large amount of effort has been made to develop systems that is able to extend…
I/O efficiency is crucial to productivity in scientific computing, but the increasing complexity of the system and the applications makes it difficult for practitioners to understand and optimize I/O behavior at scale. Data-driven machine…
Mining large-scale high-throughput tandem mass spectrometry data sets is a very important problem in mass spectrometry based protein identification. One of the fundamental problems in large scale mining of spectra is to design appropriate…
Scientific communities are increasingly adopting machine learning and deep learning models in their applications to accelerate scientific insights. High performance computing systems are pushing the frontiers of performance with a rich…
Exponential increases in scientific experimental data are outstripping the rate of progress in silicon technology. As a result, heterogeneous combinations of architectures and process or device technologies are increasingly important to…
Real-time image segmentation demands architectures that preserve fine spatial detail while capturing global context under tight latency and memory budgets. Image segmentation is one of the most fundamental problems in computer vision and…
Modern day computing increasingly relies on specialization to satiate growing performance and efficiency requirements. A core challenge in designing such specialized hardware architectures is how to perform mapping space search, i.e.,…
Data series similarity search is a core operation for several data series analysis applications across many different domains. However, the state-of-the-art techniques fail to deliver the time performance required for interactive…
Dataset condensation can be used to reduce the computational cost of training multiple models on a large dataset by condensing the training dataset into a small synthetic set. State-of-the-art approaches rely on matching the model gradients…
High-throughput sequencing (HTS) technologies have revolutionized the field of genomics, enabling rapid and cost-effective genome analysis for various applications. However, the increasing volume of genomic data generated by HTS…
Single-cell proteomics (SCP) is transforming our understanding of biological complexity by shifting from bulk proteomics, where signals are averaged over thousands of cells, to the proteome analysis of individual cells. This granular…