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Ribonucleotide reductases are encoded by many viruses, but without other enzymes of nucleotide metabolism of no obvious use. A look at the enzymes' molecular properties and their possible mutator action may give clues.

Biomolecules · Quantitative Biology 2014-03-19 Claus Bornemann

A polyglot is a file that is valid in two or more formats. Polyglot files pose a problem for malware detection systems that route files to format-specific detectors/signatures, as well as file upload and sanitization tools. In this work we…

With the rapid growth of malware attacks, more antivirus developers consider deploying machine learning technologies into their productions. Researchers and developers published various machine learning-based detectors with high precision…

Cryptography and Security · Computer Science 2021-12-07 Matthew Crawford , Wei Wang , Ruoxi Sun , Minhui Xue

The translocation of a short DNA fragment through a nanopore is addressed when the perforated membrane contains an embedded electrode. Accurate numerical solutions of the coupled Poisson, Nernst-Planck, and Stokes equations for a realistic,…

Soft Condensed Matter · Physics 2017-06-29 Thomas Töws , Peter Reimann

In this paper we study $\gamma$-structures filtered by topological genus. $\gamma$-structures are a class of RNA pseudoknot structures that plays a key role in the context of polynomial time folding of RNA pseudoknot structures. A…

Combinatorics · Mathematics 2012-02-07 Thomas J. X. Li , Christian M. Reidys

This paper tackles the problem of defending a neural network against adversarial attacks crafted with different norms (in particular $\ell_\infty$ and $\ell_2$ bounded adversarial examples). It has been observed that defense mechanisms…

Machine Learning · Computer Science 2020-02-14 Alexandre Araujo , Laurent Meunier , Rafael Pinot , Benjamin Negrevergne

RNA design shows growing applications in synthetic biology and therapeutics, driven by the crucial role of RNA in various biological processes. A fundamental challenge is to find functional RNA sequences that satisfy given structural…

Biomolecules · Quantitative Biology 2024-04-18 Han Huang , Ziqian Lin , Dongchen He , Liang Hong , Yu Li

Models for RNA secondary structures (the topology of folded RNA) without pseudo knots are disordered systems with a complex state-space below a critical temperature. Hence, a complex dynamical (glassy) behavior can be expected, when…

Disordered Systems and Neural Networks · Physics 2008-02-02 S. Wolfsheimer , B. Burghardt , A. Mann , A. K. Hartmann

Accurate RNA structure modeling remains difficult because RNA backbones are highly flexible, non-canonical interactions are prevalent, and experimentally determined 3D structures are comparatively scarce. We introduce \emph{RiboSphere}, a…

Machine Learning · Computer Science 2026-03-23 Zhou Zhang , Hanqun Cao , Cheng Tan , Fang Wu , Pheng Ann Heng , Tianfan Fu

We enumerate the number of RNA contact structures according to their genus, i.e. the topological character of their pseudoknots. By using a recently proposed matrix model formulation for the RNA folding problem, we obtain exact results for…

Biomolecules · Quantitative Biology 2009-11-10 G. Vernizzi , H. Orland , A. Zee

The vast parallelism, exceptional energy efficiency and extraordinary information inherent in DNA molecules are being explored for computing, data storage and cryptography. DNA cryptography is a emerging field of cryptography. In this paper…

Cryptography and Security · Computer Science 2011-01-14 D. Prabhu , M. Adimoolam

Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the effect of knocking…

Molecular Networks · Quantitative Biology 2015-01-19 Panagiotis Papasaikas , J. Ramon Tejedor , Luisa Vigevani , Juan Valcarcel

To test whether X-chromosome has unique genomic characteristics, X-chromosome and 22 autosomes were compared for RNA binding density. Nucleotide sequences on the chromosomes were divided into 50kb per segment that was recoded as a set of…

Genomics · Quantitative Biology 2007-05-23 Zhanjun Lu , Ying Lu , Shuxia Song , Zhai Yu , Xiufang Wang

The phenomenon of gene conservation is an interesting evolutionary problem related to speciation and adaptation. Conserved genes are acted upon in evolution in a way that preserves their function despite other structural and functional…

Genomics · Quantitative Biology 2008-07-23 Bradly J. Alicea , Marcela A. Carvallo-Pinto , Jorge L. M. Rodrigues

This paper considers the problem of matching fragment to organism using its complete genome. Our method is based on the probability measure representation of a genome. We first demonstrate that these probability measures can be modelled as…

Biological Physics · Physics 2009-11-07 V. V. Anh , K. S. Lau , Z. G. Yu

Ransomware poses a serious and fast-acting threat to critical systems, often encrypting files within seconds of execution. Research indicates that ransomware is the most reported cybercrime in terms of financial damage, highlighting the…

Cryptography and Security · Computer Science 2026-04-13 Busra Caliskan , Ibrahim Gulatas , H. Hakan Kilinc , A. Halim Zaim

Suppose we have a virus or one competing idea/product that propagates over a multiple profile (e.g., social) network. Can we predict what proportion of the network will actually get "infected" (e.g., spread the idea or buy the competing…

Social and Information Networks · Computer Science 2015-04-14 Angeliki Rapti , Kostas Tsichlas , Spiros Sioutas , Giannis Tzimas

Polyploidization is an evolutionary process by which a species acquires multiple copies of its complete set of chromosomes. The reticulate nature of the signal left behind by it means that phylogenetic networks offer themselves as a…

Populations and Evolution · Quantitative Biology 2023-02-21 Katharina T. Huber , Liam J. Maher

The human immune system protects the human body against various pathogens like e.g. biological viruses and bacteria. Artificial immune systems reuse the architecture, organization, and workflows of the human immune system for various…

Multiagent Systems · Computer Science 2008-05-14 Michael Hilker

Viruses are submicroscopic agents that can infect all kinds of lifeforms and use their hosts' living cells to replicate themselves. Despite having some of the simplest genetic structures among all living beings, viruses are highly…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Niloy Sikder , Md. Al-Masrur Khan , Anupam Kumar Bairagi , Mehedi Masud , Jun Jiat Tiang , Abdullah-Al Nahid