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Using optical speckle scanning microscopy [1], we demonstrate that clear images of multiple cells can be obtained through biological scattering tissue, with subcellular resolution and good image quality, as long as the size of the imaging…

Optics · Physics 2023-07-19 Xin Yang , Ye Pu , Demetri Psaltis

Spectral CT has great potential for a variety of clinical applications due to the improved material discrimination with respect to conventional CT. Many clinical and preclinical spectral CT systems have two spectral channels for dual-energy…

Medical Physics · Physics 2020-10-17 Matthew Tivnan , Wenying Wang , J. Webster Stayman

We have demonstrated the capability of spectral multiplexing in multi-distance diffractive imaging, enabling the reconstruction of samples with diverse spectral responses. While previous methods like ptychography utilize redundancy in…

Optics · Physics 2024-05-31 Qijun You , Lingshuo Meng , Yun Gao , Qing Liao , Wei Cao , Peixiang Lu

Spectral imaging is a fundamental diagnostic technique with widespread application. Conventional spectral imaging approaches have intrinsic limitations on spatial and spectral resolutions due to the physical components they rely on. To…

Image and Video Processing · Electrical Eng. & Systems 2021-06-07 Figen S. Oktem , Oğuzhan Fatih Kar , Can Deniz Bezek , Farzad Kamalabadi

Knowledge of x-ray attenuation is essential for developing and evaluating x-ray imaging technologies. For instance, techniques to better characterize cysts at mammography screening would be highly desirable to reduce recalls, but the…

Three-dimensional phase contrast imaging of multiply-scattering samples in X-ray and electron microscopy is extremely challenging, due to small numerical apertures, the unavailability of wavefront shaping optics, and the highly nonlinear…

Computational Physics · Physics 2021-06-02 Philipp M Pelz , Hamish G Brown , Jim Ciston , Scott D Findlay , Yaqian Zhang , Mary Scott , Colin Ophus

As photon counting detectors are being explored for medical and industrial imaging applications, there is a critical need to understand spectral characteristics of scattered x-ray photons. Scattered radiation is detrimental to x-ray imaging…

Medical Physics · Physics 2022-12-14 Cale E. Lewis , Mini Das

Multi-energy X-ray tomography is studied for decomposing three materials using three X-ray energies and a classical energy-integrating detector. A novel regularization term comprises inner products between the material distribution…

We present a physically intuitive matrix approach for wave imaging and characterization in scattering media. The experimental proof-of-concept is performed with ultrasonic waves, but this approach can be applied to any field of wave physics…

Applied Physics · Physics 2020-07-01 William Lambert , Laura A. Cobus , Mathieu Couade , Mathias Fink , Alexandre Aubry

Quantitative estimation of contrast agent concentration is made possible by spectral CT and material decomposition. There are several approaches to modulate the sensitivity of the imaging system to obtain the different spectral channels…

Medical Physics · Physics 2020-10-16 Matthew Tivnan , Wenying Wang , Grace Gang , Eleni Liapi , Peter Noel , J. Webster Stayman

Dark-field imaging based on grating interferometry is an emerging X-ray modality in medical imaging, which is particularly capable of providing complementary diagnostic information by visualizing the microstructural properties of lung…

Medical Physics · Physics 2026-05-29 Longchao Men , Peiyuan Guo , Jincheng Lu , Yan Xu , Hongxia Yin , Zhenchang Wang , Li Zhang , Zhentian Wang

Dual energy CT (DECT) enhances tissue characterization because it can produce images of basis materials such as soft-tissue and bone. DECT is of great interest in applications to medical imaging, security inspection and nondestructive…

Medical Physics · Physics 2018-09-05 Qiaoqiao Ding , Tianye Niu , Xiaoqun Zhang , Yong Long

Random scattering is usually viewed as a serious nuisance in optical imaging, and needs to be prevented in the conventional imaging scheme based on single-photon interference. Here we proposed a two-photon imaging scheme with the widely…

Optics · Physics 2018-09-25 Peilong Hong

Rayleigh scattering has shown powerful abilities to study electron resonances of nanomaterials regardless of the specific shapes. In analogy to Rayleigh scattering, here we demonstrate that edge optical scattering from two-dimensional (2D)…

Mesoscale and Nanoscale Physics · Physics 2018-04-04 Huaiyi Ding , Yiyun Dong , Sijia Li , Nan Pan , Yi Luo , Xiaoping Wang

Spectral imaging enables the analysis of optical material properties that are invisible to the human eye. Different spectral capturing setups, e.g., based on filter-wheel, push-broom, line-scanning, or mosaic cameras, have been introduced…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Eric L. Wisotzky , Jost Triller , Anna Hilsmann , Peter Eisert

Standard dual-energy computed tomography (CT) uses two different X-ray energies to obtain energy-dependent tissue attenuation information to allow quantitative material decomposition. The combined use of dual-energy CT and positron emission…

Medical Physics · Physics 2020-12-30 Guobao Wang

Light passing through scattering media will be strongly scattered and diffused into complex speckle pattern, which however contains almost all the spatial information and color information of the objects. Although various technologies have…

Image and Video Processing · Electrical Eng. & Systems 2019-07-30 Lei Zhu , Yuxiang Wu , Jietao Liu , Tengfei Wu , Lixian Liu , Xiaopeng Shao

Recent innovations in x-ray technology (namely phase-based and energy-resolved imaging) offer unprecedented opportunities for material discrimination, however they are often used in isolation or in limited combinations. Here we show that…

Scintillators have been widely used in X-ray imaging due to their ability to convert high-energy radiation into visible light, making them essential for applications such as medical imaging and high-energy physics. Recent advances in the…

Instrumentation and Detectors · Physics 2025-04-14 Seokhwan Min , Seou Choi , Simo Pajovic , Sachin Vaidya , Nicholas Rivera , Shanhui Fan , Marin Soljačić , Charles Roques-Carmes

Material decomposition refers to using the energy dependence of material physical properties to differentiate materials in a sample, which is a very important application in computed tomography(CT). In propagation-based X-ray phase-contrast…

Medical Physics · Physics 2023-12-01 Suyu Liao , Huitao Zhang , Peng Zhang , Yining Zhu