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The long duration of the COVID-19 pandemic allowed for multiple bursts in the infection and death rates, the so-called epidemic waves. This complex behavior is no longer tractable by simple compartmental model and requires more…

Our aim is to establish a framework where reinforcement learning (RL) of optimizing interventions retrospectively allows us a regulatory compliant pathway to prospective clinical testing of the learned policies in a clinical deployment. We…

Machine Learning · Computer Science 2020-03-20 Luchen Li , Ignacio Albert-Smet , Aldo A. Faisal

Mathematical models are instrumental to forecast the spread of pathogens and to evaluate the effectiveness of non-pharmaceutical measures. A plethora of optimal strategies has been recently developed to minimize either the infected peak…

Dynamical Systems · Mathematics 2021-11-11 J. Sereno , A. L. Anderson , A. Ferramosca , E. A. Hernandez-Vargas , A. H. Gonzalez

Epidemiological compartmental models are useful for understanding infectious disease propagation and directing public health policy decisions. Calibration of these models is an important step in offering accurate forecasts of disease…

Machine Learning · Computer Science 2023-12-12 Nikunj Gupta , Anh Mai , Azza Abouzied , Dennis Shasha

Downsizing the US public health workforce throughout 2025 amplifies potential risks during public health crises. Expert judgment from public health officials represents a vital information source, distinct from traditional surveillance…

Populations and Evolution · Quantitative Biology 2025-08-22 Garrik Hoyt , Eleanor Bergren , Gabrielle String , Thomas McAndrew

Nowadays, time series forecasting is predominantly approached through the end-to-end training of deep learning architectures using error-based objectives. While this is effective at minimizing average loss, it encourages the encoder to…

Machine Learning · Computer Science 2026-03-26 Jiacheng Wang , Liang Fan , Baihua Li , Luyan Zhang

Forecasting transmission of infectious diseases, especially for vector-borne diseases, poses unique challenges for researchers. Behaviors of and interactions between viruses, vectors, hosts, and the environment each play a part in…

Applications · Statistics 2020-06-02 Stephen A Lauer , Alexandria C Brown , Nicholas G Reich

Accurate forecasting of infectious disease incidence is critical for public health planning and timely intervention. While most data-driven forecasting approaches rely primarily on historical data from a single country, such data are often…

Populations and Evolution · Quantitative Biology 2026-01-29 Zacharias Komodromos , Kleanthis Malialis , Artemis Kontou , Panayiotis Kolios

We study how international flights can facilitate the spread of an epidemic to a worldwide scale. We combine an infrastructure network of flight connections with a population density dataset to derive the mobility network, and then we…

Physics and Society · Physics 2021-07-26 Hugo Dolan , Riccardo Rastelli

Integrating heterogeneous data sources and expert knowledge is essential for overcoming data scarcity and enhancing estimation accuracy. Two main frameworks naturally arise to perform the integration of these multiple sources: sequential…

Methodology · Statistics 2025-11-26 Mario Figueira , David Conesa , Antonio López-Quílez , Håvard Rue

The evolution of the hemagglutinin amino acids sequences of Influenza A virus is studied by a method based on an informational metrics, originally introduced by Rohlin for partitions in abstract probability spaces. This metrics does not…

Populations and Evolution · Quantitative Biology 2015-06-03 Raffaella Burioni , Riccardo Scalco , Mario Casartelli

Stochastic infectious disease models capture uncertainty in public health outcomes and have become increasingly popular in epidemiological practice. However, calibrating these models to observed data is challenging with existing methods for…

Methodology · Statistics 2024-12-18 Prayag Chatha , Fan Bu , Jeffrey Regier , Evan Snitkin , Jon Zelner

We consider a remote inference system with multiple modalities, where a multimodal machine learning (ML) model performs real-time inference using features collected from remote sensors. When sensor observations evolve dynamically over time,…

Machine Learning · Computer Science 2026-04-28 Keyuan Zhang , Yin Sun , Bo Ji

Reinforcement learning (RL) is a promising approach to generate treatment policies for sepsis patients in intensive care. While retrospective evaluation metrics show decreased mortality when these policies are followed, studies with…

Machine Learning · Computer Science 2024-04-11 Unnseo Park , Venkatesh Sivaraman , Adam Perer

Performative prediction characterizes environments where predictive models alter the very data distributions they aim to forecast, triggering complex feedback loops. While prior research treats single-agent and multi-agent performativity as…

Machine Learning · Statistics 2026-02-04 Zhixian Zhang , Xiaotian Hou , Linjun Zhang

This article describes a new method for estimating weekly incidence (new onset) of symptoms consistent with Influenza and COVID-19, using data from the Flutracking survey. The method mitigates some of the known self-selection and…

Bias in medical artificial intelligence is conventionally viewed as a defect requiring elimination. However, human reasoning inherently incorporates biases shaped by education, culture, and experience, suggesting their presence may be…

Artificial Intelligence · Computer Science 2026-03-05 Farhad Abtahi , Mehdi Astaraki , Fernando Seoane

Contact-tracing is an essential tool in order to mitigate the impact of pandemic such as the COVID-19. In order to achieve efficient and scalable contact-tracing in real time, digital devices can play an important role. While a lot of…

Contemporary Epidemiological Surveillance (ES) relies heavily on data analytics. These analytics are critical input for pandemics preparedness networks; however, this input is not integrated into a form suitable for decision makers or…

Artificial Intelligence · Computer Science 2020-08-11 Svetlana Yanushkevich , Vlad Shmerko

Forecasting the future course of epidemics has always been one of the main goals of epidemic modelling. This chapter reviews statistical methods to quantify the accuracy of epidemic forecasts. We distinguish point and probabilistic…

Methodology · Statistics 2019-12-19 Leonhard Held , Sebastian Meyer