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Deep reinforcement learning (DRL) has been applied to a variety of problems during the past decade, and has provided effective control strategies in high-dimensional and non-linear situations that are challenging to traditional methods.…

Fluid Dynamics · Physics 2023-04-07 Colin Vignon , Jean Rabault , Ricardo Vinuesa

The integration of real-world data (RWD) and randomized controlled trials (RCT) is increasingly important for advancing causal inference in scientific research. This combination holds great promise for enhancing the efficiency of causal…

Methodology · Statistics 2024-07-02 Xi Lin , Jens Magelund Tarp , Robin J. Evans

A comprehensive view of factors associated with AD/ADRD will significantly aid in studies to develop new treatments for AD/ADRD and identify high-risk populations and patients for prevention efforts. In our study, we summarized the risk…

Artificial Intelligence · Computer Science 2024-02-27 Aokun Chen , Qian Li , Yu Huang , Yongqiu Li , Yu-neng Chuang , Xia Hu , Serena Guo , Yonghui Wu , Yi Guo , Jiang Bian

Clinical decision support systems (CDSS) augmented with artificial intelligence (AI) models are emerging as potentially valuable tools in healthcare. Despite their promise, the development and implementation of these systems typically…

Human-Computer Interaction · Computer Science 2023-03-08 Grace Golden , Christina Popescu , Sonia Israel , Kelly Perlman , Caitrin Armstrong , Robert Fratila , Myriam Tanguay-Sela , David Benrimoh

Monitoring the biomedical literature for cases of Adverse Drug Reactions (ADRs) is a critically important and time consuming task in pharmacovigilance. The development of computer assisted approaches to aid this process in different forms…

Computation and Language · Computer Science 2018-04-25 Diego Saldana Miranda

The emergence of powerful artificial intelligence is defining new research directions in neuroscience. To date, this research has focused largely on deep neural networks trained using supervised learning, in tasks such as image…

Artificial Intelligence · Computer Science 2020-07-09 Matthew Botvinick , Jane X. Wang , Will Dabney , Kevin J. Miller , Zeb Kurth-Nelson

Decades of research in artificial intelligence (AI) have produced formidable technologies that are providing immense benefit to industry, government, and society. AI systems can now translate across multiple languages, identify objects in…

Computers and Society · Computer Science 2019-08-08 Yolanda Gil , Bart Selman

Drug overdose deaths, including those due to prescription opioids, represent a critical public health issue in the United States and worldwide. Artificial intelligence (AI) approaches have been developed and deployed to help prescribers…

Human-Computer Interaction · Computer Science 2025-02-18 Venkatesh Sivaraman , Yejun Kwak , Courtney Kuza , Qingnan Yang , Kayleigh Adamson , Katie Suda , Lu Tang , Walid Gellad , Adam Perer

Recent advances in artificial intelligence (AI) and machine learning have created a general perception that AI could be used to solve complex problems, and in some situations over-hyped as a tool that can be so easily used. Unfortunately,…

Artificial Intelligence · Computer Science 2018-04-27 Jinyang Gao , Wei Wang , Meihui Zhang , Gang Chen , H. V. Jagadish , Guoliang Li , Teck Khim Ng , Beng Chin Ooi , Sheng Wang , Jingren Zhou

Generative artificial intelligence (AI) has brought revolutionary innovations in various fields, including medicine. However, it also exhibits limitations. In response, retrieval-augmented generation (RAG) provides a potential solution,…

Artificial Intelligence · Computer Science 2024-06-19 Rui Yang , Yilin Ning , Emilia Keppo , Mingxuan Liu , Chuan Hong , Danielle S Bitterman , Jasmine Chiat Ling Ong , Daniel Shu Wei Ting , Nan Liu

Artificial neural network (ANN) has been widely used due to its strong nonlinear mapping ability, fault tolerance and self-learning ability. This article summarizes the development history of artificial neural networks, introduces three…

Systems and Control · Electrical Eng. & Systems 2021-10-12 Fei Liang , Taowen Zhang

Deep Reinforcement Learning (DRL) is considered a potential framework to improve many real-world autonomous systems; it has attracted the attention of multiple and diverse fields. Nevertheless, the successful deployment in the real world is…

Machine Learning · Computer Science 2021-07-08 Juan Jose Garau-Luis , Edward Crawley , Bruce Cameron

Dry eye disease (DED) has a prevalence of between 5 and 50\%, depending on the diagnostic criteria used and population under study. However, it remains one of the most underdiagnosed and undertreated conditions in ophthalmology. Many tests…

Clinical trials are an indispensable part of the drug development process, bridging the gap between basic research and clinical application. During the development of new drugs, clinical trials are used not only to evaluate the safety and…

Access to accurate and actionable harm reduction information can directly impact the health outcomes of People Who Use Drugs (PWUD), yet existing online channels often fail to meet their diverse and dynamic needs due to limitations in…

Human-Computer Interaction · Computer Science 2025-07-15 Kaixuan Wang , Jason T. Jacques , Chenxin Diao , Carl-Cyril J Dreue

The rapid advance of generative AI is reshaping the strategic vision for R&D across industries. The unique challenges of pharmaceutical R&D will see applications of generative AI deliver value along the entire value chain from early…

Quantitative Methods · Quantitative Biology 2023-12-21 Guy Doron , Sam Genway , Mark Roberts , Sai Jasti

Real-World Data (RWD), with its large sample sizes and rich clinical detail, offers a compelling alternative to randomized controlled trials (RCTs) for studying treatment effects in diverse and complex patient populations. However, its…

Applications · Statistics 2026-05-26 Yifei Xu , Hwiyoung Lee , Zhenyao Ye , Yezhi Pan , Jingsong Zhou , Yun Yang , Chixiang Chen , Shuo Chen

The use of multiple drugs accounts for almost 30% of all hospital admission and is the 5th leading cause of death in America. Since over 30% of all adverse drug events (ADEs) are thought to be caused by drug-drug interactions (DDI), better…

Quantitative Methods · Quantitative Biology 2020-09-02 Ricky Wang

Artificial Intelligence (AI) has become an important part of our everyday lives, yet user requirements for designing AI-assisted systems in law enforcement remain unclear. To address this gap, we conducted qualitative research on…

Since deep neural networks' resurgence, reinforcement learning has gradually strengthened and surpassed humans in many conventional games. However, it is not easy to copy these accomplishments to autonomous driving because state spaces are…

Robotics · Computer Science 2023-02-14 B. Udugama