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A photoacoustic contrast mechanism is presented based on the photoacoustic fluctuations induced by microbubbles flowing inside a micro vessel filled with a continuous absorber. It is demonstrated that the standard deviation of a homogeneous…
Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation by tissue optical properties, an effect that causes spectral corruption. Predictions of the spectral variations of…
Various morphological and functional parameters of peripheral nerves and their vascular supply are indicative of pathological changes due to injury or disease. Based on recent improvements in optoacoustic image quality, we explore the…
Laser treatment has emerged into a cornerstone of industrial manufacturing. This creates the demand to understand in detail the involved physical processes and their dynamics, to control the process, and to keep guard in-situ the laser…
Optical microscopy has so far been restricted to superficial layers, leaving many important biological questions unanswered. Random scattering causes the ballistic focus, which is conventionally used for image formation, to decay…
Recent advances in types and extent of medical imaging technologies has led to proliferation of multimodal quantitative imaging data in cancer. Quantitative medical imaging data refer to numerical representations derived from medical…
The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the TME are acidosis and hypoxia, both of which are considered hallmarks of tumours as well as critical factors…
Medical ultrasound imaging is the most widespread real-time non-invasive imaging system and its formulation comprises signal transmission, signal reception, and image formation. Ultrasound signal transmission modelling has been formalized…
Magneto-acoustic tomography combines near-field radio-frequency (RF) and ultrasound with the aim of creating a safe, high resolution, high contrast hybrid imaging technique. We present continuous-wave magneto-acoustic imaging techniques,…
Breast cancer is a disease in which cells in the breast grow out of control. After surgery, chemotherapy, and other invasive treatments, hyperthermia is a suitable choice with the minimal side effects. In this paper, the treatment of breast…
Histological images are critical in the diagnosis and treatment of cancers. Unfortunately, the current method for capturing these microscopy images require resource intensive tissue preparation that delays diagnosis for many days to a few…
Imaging through opaque, highly scattering walls is a long sought after capability with potential applications in a variety of fields. The use of wavefront shaping to compensate for scattering has brought a renewed interest as a potential…
Non-invasive imaging of deep blood vessels for mapping hemodynamics remains an open quest in biomedical optical imaging. Although pure optical imaging techniques offer rich optical contrast of blood and have been reported to measure blood…
Central nervous system (CNS) tumors come with the vastly heterogeneous histologic, molecular and radiographic landscape, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics…
Although the photoacoustic effect is most commonly generated by pulsed or amplitude modulated continuous optical sources, it is possible to generate acoustic waves by moving a constant amplitude, continuous light beam. If the light beam…
Fourier ptychographic microscopy (FPM) is a recently developed imaging modality that uses angularly varying illumination to extend a system performance beyond the limit defined by its optical elements. The FPM technique applies a novel…
With the continued evolution of modern radiation therapy towards high precision delivery of high therapeutic doses to the tumour while optimally sparing surrounding healthy tissue, imaging becomes a crucial component to identify the…
Accurate measurement of optical absorption coefficients from photoacoustic imaging (PAI) data would enable direct mapping of molecular concentrations, providing vital clinical insight. The ill-posed nature of the problem of absorption…
Thermoacoustic tomography (TAT) is an imaging modality based on the thermoacoustic effect. In TAT, a short microwave or radio wave pulse is directed to the imaged target. The energy of the electromagnetic pulse is absorbed depending on the…
There has been an explosion of interest in time-varying photonics due to the recent discovery and design of materials and metamaterials with strong, time-varying, nonlinear optical responses. This opens the door to novel optical phenomena…