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Molecular phenotyping is central in cancer precision medicine, but remains costly and standard methods only provide a tumour average profile. Microscopic morphological patterns observable in histopathology sections from tumours are…

Image and Video Processing · Electrical Eng. & Systems 2020-09-21 Yinxi Wang , Kimmo Kartasalo , Masi Valkonen , Christer Larsson , Pekka Ruusuvuori , Johan Hartman , Mattias Rantalainen

In breast surgical planning, accurate registration of MR images across patient positions has the potential to improve the localisation of tumours during breast cancer treatment. While learning-based registration methods have recently become…

Accurate automated detection of recurrent prostate cancer in PSMA PET/CT scans is challenging due to heterogeneous lesion size, activity, anatomical location, and intra- and inter-class imbalances. Conventional deep learning loss functions…

Image and Video Processing · Electrical Eng. & Systems 2026-03-17 Obed Korshie Dzikunu , Shadab Ahamed , Amirhossein Toosi , Xiaoxiao Li , Arman Rahmim

One of the fundamental challenges in supervised learning for multimodal image registration is the lack of ground-truth for voxel-level spatial correspondence. This work describes a method to infer voxel-level transformation from…

This paper presents a predictive model for estimating regularization parameters of diffeomorphic image registration. We introduce a novel framework that automatically determines the parameters controlling the smoothness of diffeomorphic…

Image and Video Processing · Electrical Eng. & Systems 2022-02-08 Jian Wang , Miaomiao Zhang

This study investigates the use of the unsupervised deep learning framework VoxelMorph for deformable registration of longitudinal abdominopelvic CT images acquired in patients with bone metastases from breast cancer. The CT images were…

Ultrasound imaging is a cost-effective and radiation-free modality for visualizing anatomical structures in real-time, making it ideal for guiding surgical interventions. However, its limited field-of-view, speckle noise, and imaging…

Image and Video Processing · Electrical Eng. & Systems 2024-04-26 Remi Delaunay , Ruisi Zhang , Filipe C. Pedrosa , Navid Feizi , Dianne Sacco , Rajni Patel , Jayender Jagadeesan

Background: Cribriform morphology in prostate cancer is a histological feature that indicates poor prognosis and contraindicates active surveillance. However, it remains underreported and subject to significant interobserver variability…

Purpose: Accurate 3D MRI-ultrasound (US) deformable registration is critical for real-time guidance in high-dose-rate (HDR) prostate brachytherapy. We present a weakly supervised spatial implicit neural representation (SINR) method to…

Medical Physics · Physics 2025-03-19 Jing Wang , Ruirui Liu , Yu Lei , Michael J. Baine , Tian Liu , Yang Lei

Prostate cancer (PCa) is one of the most common cancers in men worldwide. Bi-parametric MRI (bp-MRI) and clinical variables are crucial for PCa identification and improving treatment decisions. However, this process is subjective to expert…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Juan A. Olmos , Antoine Manzanera , Fabio Martínez

Pathologies systematically induce morphological changes, thus providing a major but yet insufficiently quantified source of observables for diagnosis. The study develops a predictive model of the pathological states based on morphological…

The emergence of real-time 3D ultrasound (US) makes it possible to consider image-based tracking of subcutaneous soft tissue targets for computer guided diagnosis and therapy. We propose a 3D transrectal US based tracking system for precise…

Other Computer Science · Computer Science 2008-01-17 Michael Baumann , Pierre Mozer , Vincent Daanen , Jocelyne Troccaz

Image registration is a fundamental step in medical image analysis. Ideally, the transformation that registers one image to another should be a diffeomorphism that is both invertible and smooth. Traditional methods like geodesic shooting…

Computer Vision and Pattern Recognition · Computer Science 2019-07-02 Dongyang Kuang

Mathematical morphology is a theory and technique to collect features like geometric and topological structures in digital images. Given a target image, determining suitable morphological operations and structuring elements is a cumbersome…

Computer Vision and Pattern Recognition · Computer Science 2019-09-05 Yucong Shen , Xin Zhong , Frank Y. Shih

Image registration is a key technique in medical image analysis to estimate deformations between image pairs. A good deformation model is important for high-quality estimates. However, most existing approaches use ad-hoc deformation models…

Computer Vision and Pattern Recognition · Computer Science 2019-04-23 Marc Niethammer , Roland Kwitt , Francois-Xavier Vialard

Diffeomorphic image registration (DIR) is a fundamental task in 3D medical image analysis that seeks topology-preserving deformations between image pairs. To ensure diffeomorphism, a common approach is to model the deformation field as the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Mohammadjavad Matinkia , Nilanjan Ray

Deformable registration is crucial in medical imaging. Several existing applications include lesion tracking, probabilistic atlas generation, and treatment response evaluation. However, current methods often lack robustness and…

Image and Video Processing · Electrical Eng. & Systems 2026-03-04 Yunzheng Zhu , Aichi Chien , Kimaya kulkarni , Luoting Zhuang , Stephen Park , Ricky Savjani , Daniel Low , William Hsu

The joint utilization of diverse data sources for medical imaging segmentation has emerged as a crucial area of research, aiming to address challenges such as data heterogeneity, domain shift, and data quality discrepancies. Integrating…

Computer Vision and Pattern Recognition · Computer Science 2024-04-04 Eddardaa B. Loussaief , Mohammed Ayad , Domenc Puig , Hatem A. Rashwan

Joint image registration and segmentation has long been an active area of research in medical imaging. Here, we reformulate this problem in a deep learning setting using adversarial learning. We consider the case in which fixed and moving…

Image and Video Processing · Electrical Eng. & Systems 2019-07-01 Mohamed S. Elmahdy , Jelmer M. Wolterink , Hessam Sokooti , Ivana Išgum , Marius Staring

Accurate detection of ultrasound nodules is essential for the early diagnosis and treatment of thyroid and breast cancers. However, this task remains challenging due to irregular nodule shapes, indistinct boundaries, substantial scale…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Jingjing Wang , Zhuo Xiao , Xinning Yao , Bo Liu , Lijuan Niu , Xiangzhi Bai , Fugen Zhou
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