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Recently, deep learning (DL) has automated and accelerated the clinical radiation therapy (RT) planning significantly by predicting accurate dose maps. However, most DL-based dose map prediction methods are data-driven and not applicable…
The density fields constructed by traditional mass assignment methods are susceptible to irritating discreteness, which hinders morphological measurements of cosmic large-scale structure (LSS) through Minkowski functionals (MFs). For…
This work presents a novel framework for time series analysis using entropic measures based on the kernel density estimate (KDE) of the time series' Takens' embeddings. Using this framework we introduce two distinct analytical tools: (1) a…
Topographic mapping in planetary environments relies on accurate 3D scan registration methods. However, most global registration algorithms relying on features such as FPFH and Harris-3D show poor alignment accuracy in these settings due to…
Genomic phenotypes, such as DNA methylation and chromatin accessibility, can be used to characterize the transcriptional and regulatory activity of DNA within a cell. Recent technological advances have made it possible to measure such…
Breast cancer continues to be a significant cause of mortality among women globally. Timely identification and precise diagnosis of breast abnormalities are critical for enhancing patient prognosis. In this study, we focus on improving the…
Organoids are multi-cellular structures which are cultured in vitro from stem cells to resemble specific organs (e.g., brain, liver) in their three-dimensional composition. Dynamic changes in the shape and composition of these model systems…
DNA methylation is an intensely studied epigenetic mark implicated in many biological processes of direct clinical relevance. While sequencing based technologies are increasingly allowing high resolution measurements of DNA methylation,…
Cell instance segmentation in fluorescence microscopy images is becoming essential for cancer dynamics and prognosis. Data extracted from cancer dynamics allows to understand and accurately model different metabolic processes such as…
A novel image matching method is proposed that utilizes learned features extracted by an off-the-shelf deep neural network to obtain a promising performance. The proposed method uses pre-trained VGG architecture as a feature extractor and…
Purpose: We propose a general framework for quantifying predictive uncertainties of dose-related quantities and leveraging this information in a dose mimicking problem in the context of automated radiation therapy treatment planning.…
Diffeomorphic image registration is a fundamental step in medical image analysis, owing to its capability to ensure the invertibility of transformations and preservation of topology. Currently, unsupervised learning-based registration…
A complete representation of 3D objects requires characterizing the space of deformations in an interpretable manner, from articulations of a single instance to changes in shape across categories. In this work, we improve on a prior…
In recent years, geotagged social media has become popular as a novel source for geographic knowledge discovery. Ground-level images and videos provide a different perspective than overhead imagery and can be applied to a range of…
Accurate annotation of fixation type is a critical step in slide preparation for pathology laboratories. However, this manual process is prone to errors, impacting downstream analyses and diagnostic accuracy. Existing methods for verifying…
This study innovates geometric morphometrics by incorporating functional data analysis, the square-root velocity function (SRVF), and arc-length parameterisation for 3D morphometric data, leading to the development of seven new pipelines in…
Large-scale agent systems have foreseeable applications in the near future. Estimating their macroscopic density is critical for many density-based optimization and control tasks, such as sensor deployment and city traffic scheduling. In…
Understanding the morphological structure of medical images and precisely segmenting the region of interest or abnormality is an important task that can assist in diagnosis. However, the unique properties of medical imaging make clear…
We present a longitudinal MR simulation framework which simulates the future neurodegenerative progression by outputting the predicted follow-up MR image and the voxel-based morphometry (VBM) map. This framework expects the patients to have…
We introduce the Push-Forward Signed Distance Morphometric (PF-SDM) for shape quantification in biomedical imaging. The PF-SDM compactly encodes geometric and topological properties of closed shapes, including their skeleton and symmetries.…