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Efficient text indexing data structures have enabled large-scale genomic sequence analysis and are used to help solve problems ranging from assembly to read mapping. However, these data structures typically assume that the underlying…

Genomics · Quantitative Biology 2016-04-13 Nitish Gupta , Komal Sanjeev , Tim Wall , Carl Kingsford , Rob Patro

The rapid growth of artificial intelligence (AI) has made low-precision formats such as FP16, FP8, and, most recently, block-scaled FP4 the primary focus of modern GPUs, where Tensor Cores now deliver orders-of-magnitude higher throughput…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-19 Angelika Schwarz , Anton Anders , Cole Brower , Harun Bayraktar , John Gunnels , Kate Clark , RuQing G. Xu , Samuel Rodriguez , Sebastien Cayrols , Paweł Tabaszewski , Victor Podlozhnyuk

Optimization acceleration techniques such as momentum play a key role in state-of-the-art machine learning algorithms. Recently, generic vector sequence extrapolation techniques, such as regularized nonlinear acceleration (RNA) of Scieur et…

Optimization and Control · Mathematics 2019-05-29 Aritra Dutta , El Houcine Bergou , Yunming Xiao , Marco Canini , Peter Richtárik

Structured, or tabular, data is the most common format in data science. While deep learning models have proven formidable in learning from unstructured data such as images or speech, they are less accurate than simpler approaches when…

Edge inference for large language models (LLM) offers secure, low-latency, and cost-effective inference solutions. We emphasize that an edge accelerator should achieve high area efficiency and minimize external memory access (EMA) during…

Hardware Architecture · Computer Science 2025-07-15 Chun-Ting Chen , HanGyeol Mun , Jian Meng , Mohamed S. Abdelfattah , Jae-sun Seo

Genome-to-genome comparisons require designating anchor points, which are given by Maximum Exact Matches (MEMs) between their sequences. For large genomes this is a challenging problem and the performance of existing solutions, even in…

Data Structures and Algorithms · Computer Science 2018-05-24 Szymon Grabowski , Wojciech Bieniecki

This study presents advanced neural network architectures including Convolutional Neural Networks (CNN), Recurrent Neural Networks (RNN), Long Short-Term Memory Networks (LSTMs), and Deep Belief Networks (DBNs) for enhanced ECG signal…

Hardware Architecture · Computer Science 2023-07-18 Kayode Inadagbo , Baran Arig , Nisanur Alici , Murat Isik

To extract the relevant features in a given dataset is a difficult task, recently resolved in the non-negative data case with the Non-negative Matrix factorization (NMF) method. The objective of this research work is to extend this method…

Large Language Models (LLMs) impose massive computational demands, driving the need for scalable multi-chiplet accelerators. However, existing mapping space exploration efforts for such accelerators primarily focus on traditional…

Hardware Architecture · Computer Science 2026-04-02 Boyu Li , Zongwei Zhu , Yi Xiong , Qianyue Cao , Jiawei Geng , Xiaonan Zhang , Xi Li

Fully Homomorphic Encryption (FHE) imposes substantial memory bandwidth demands, presenting significant challenges for efficient hardware acceleration. Near-memory Processing (NMP) has emerged as a promising architectural solution to…

Hardware Architecture · Computer Science 2025-04-01 Shangyi Shi , Husheng Han , Jianan Mu , Xinyao Zheng , Ling Liang , Hang Lu , Zidong Du , Xiaowei Li , Xing Hu , Qi Guo

Text indexing is a fundamental and well-studied problem. Classic solutions either replace the original text with a compressed representation, e.g., the FM-index and its variants, or keep it uncompressed but attach some redundancy - an index…

Data Structures and Algorithms · Computer Science 2026-02-05 Lorraine A. K. Ayad , Gabriele Fici , Ragnar Groot Koerkamp , Grigorios Loukides , Rob Patro , Giulio Ermanno Pibiri , Solon P. Pissis

Stereo depth estimation is used for many computer vision applications. Though many popular methods strive solely for depth quality, for real-time mobile applications (e.g. prosthetic glasses or micro-UAVs), speed and power efficiency are…

Image and Video Processing · Electrical Eng. & Systems 2019-08-09 Oscar Rahnama , Tommaso Cavallari , Stuart Golodetz , Simon Walker , Philip H. S. Torr

The GEneral Matrix Multiplication (GEMM) is one of the essential algorithms in scientific computing. Single-thread GEMM implementations are well-optimised with techniques like blocking and autotuning. However, due to the complexity of…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-15 Yufan Xia , Marco De La Pierre , Amanda S. Barnard , Giuseppe Maria Junior Barca

Pairwise sequence alignment is a very time-consuming step in common bioinformatics pipelines. Speeding up this step requires heuristics, efficient implementations, and/or hardware acceleration. A promising candidate for all of the above is…

Hardware Architecture · Computer Science 2023-04-14 Joël Lindegger , Damla Senol Cali , Mohammed Alser , Juan Gómez-Luna , Nika Mansouri Ghiasi , Onur Mutlu

As genome sequencing is finding utility in a wide variety of domains beyond the confines of traditional medical settings, its computational pipeline faces two significant challenges. First, the creation of up to 0.5 GB of data per minute…

Deep Neural Networks (DNN's) are a widely-used solution for a variety of machine learning problems. However, it is often necessary to invest a significant amount of a data scientist's time to pre-process input data, test different neural…

Machine Learning · Computer Science 2022-05-27 Anish Thite , Mohan Dodda , Pulak Agarwal , Jason Zutty

An efficient hardware implementation for Simultaneous Localization and Mapping (SLAM) methods is of necessity for mobile autonomous robots with limited computational resources. In this paper, we propose a resource-efficient FPGA…

Signal Processing · Electrical Eng. & Systems 2023-05-31 Keisuke Sugiura , Hiroki Matsutani

The rapid advancements in artificial intelligence (AI), particularly the Large Language Models (LLMs), have profoundly affected our daily work and communication forms. However, it is still a challenge to deploy LLMs on resource-constrained…

Hardware Architecture · Computer Science 2025-03-03 Mingqiang Huang , Ao Shen , Kai Li , Haoxiang Peng , Boyu Li , Yupeng Su , Hao Yu

Multimodal deep learning harnesses diverse imaging modalities, such as MRI sequences, to enhance diagnostic accuracy in medical imaging. A key challenge is determining the optimal timing for integrating these modalities-specifically,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Valerio Guarrasi , Klara Mogensen , Sara Tassinari , Sara Qvarlander , Paolo Soda

Many modern sequence alignment tools implement fast string matching using the space efficient data structure called FM-index. The succinct nature of this data structure presents unique challenges for the algorithm designers. In this paper,…

Data Structures and Algorithms · Computer Science 2019-09-04 Roman Snytsar
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