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The world is still struggling in controlling and containing the spread of the COVID-19 pandemic caused by the SARS-CoV-2 virus. The medical conditions associated with SARS-CoV-2 infections have resulted in a surge in the number of patients…

Image and Video Processing · Electrical Eng. & Systems 2021-05-04 Hossein Aboutalebi , Maya Pavlova , Mohammad Javad Shafiee , Ali Sabri , Amer Alaref , Alexander Wong

The recent outbreak of COVID-19 has led to urgent needs for reliable diagnosis and management of SARS-CoV-2 infection. As a complimentary tool, chest CT has been shown to be able to reveal visual patterns characteristic for COVID-19, which…

Background: Global viral threats underscore the need for effective genomic surveillance, but high costs and uneven resource distribution hamper its implementation. Targeting surveillance to international travelers in major travel hubs may…

Populations and Evolution · Quantitative Biology 2025-02-14 Haogao Gu , Jifan Li , Wanying Sun , Mengting Li , Kathy Leung , Joseph T. Wu , Hsiang-Yu Yuan , Maggie H. Wang , Bingyi Yang , Matthew R. McKay , Ning Ning , Leo L. M. Poon

The SARS-CoV2 virus has caused a lot of tribulation to the human population. Predictive modeling that can accurately determine whether a person is infected with COVID-19 is imperative. The study proposes a novel approach that utilizes deep…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Jash Dalvi , Aziz Bohra

Due to SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) being a novel virus, there are currently no known effective antiviral drugs capable of slowing its progress. To accelerate the discovery of potential drug candidates,…

Biomolecules · Quantitative Biology 2020-09-29 Lokesh Agrawal , Thanasis Poullikkas , Scott Eisenhower , Carlo Monsanto , Ranjith Kumar Bakku

Since the first reports of a coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome virus (SARS-CoV-2) in Wuhan, Hubei province, China, scientists are working around the clock to find sound answers to the…

Genomics · Quantitative Biology 2020-10-02 Nabil Abid , Giovanni Chillemi , Ahmed Rebai

SARS-CoV-2 is colloquially known as COVID-19 that had an initial outbreak in December 2019. The deadly virus has spread across the world, taking part in the global pandemic disease since March 2020. In addition, a recent variant of…

The UK Office for National Statistics (ONS) publish a regular infection survey that reports data on positive RT-PCR test results for SARS-COV-2 virus. This survey reports that a large proportion of positive test results may be based on the…

Applications · Statistics 2021-03-19 Martin Neil

The question of how SARS-CoV-2 is transmitted remains surprisingly controversial today, especially with reference to airborne transmission. In fact, despite a large body of scientific evidence, health and regulatory authorities still…

Medical Physics · Physics 2021-10-07 G. Buonanno , A. Robotto , E. Brizio , L. Morawska , A. Civra , F. Corino , D. Lembo , G. Ficco , L. Stabile

Sequence data, such as DNA, RNA, and protein sequences, exhibit intricate, multi-scale structures that pose significant challenges for conventional analysis methods, particularly those relying on alignment or purely statistical…

Genomics · Quantitative Biology 2025-10-22 Jian Liu , Li Shen , Mushal Zia , Guo-Wei Wei

Genome-wide epistasis analysis is a powerful tool to infer gene interactions, which can guide drug and vaccine development and lead to a deeper understanding of microbial pathogenesis. We have considered all complete SARS-CoV-2 genomes…

Quantitative Methods · Quantitative Biology 2022-05-18 Hong-Li Zeng , Vito Dichio , Edwin Rodríguez Horta , Kaisa Thorell , Erik Aurell

With the rapid global spread of COVID-19, more and more data related to this virus is becoming available, including genomic sequence data. The total number of genomic sequences that are publicly available on platforms such as GISAID is…

Genomics · Quantitative Biology 2021-11-16 Sarwan Ali , Murray Patterson

The recent zoonotic coronavirus virus outbreak of a novel type [COVID 19] has necessitated the adequate understanding of the evolutionary pathway of zoonotic viruses which adversely affects human populations for therapeutic constructs to…

Other Quantitative Biology · Quantitative Biology 2020-05-07 Adejoke Olukayode Obajuluwa , Pius Abimbola Okiki , Tiwalola Madoc Obajuluwa , Olakunle Bamikole Afolabi

The aim of the study is to analyze viruses using parameters obtained from distributions of nucleotide sequences in the viral RNA. Seeking for the input data homogeneity, we analyze single-stranded RNA viruses only. Two approaches are used…

Other Quantitative Biology · Quantitative Biology 2022-04-25 Mykola Husev , Andrij Rovenchak

Predicting the future evolutionary trajectory of SARS-CoV-2 remains a critical challenge, particularly due to the pivotal role of spike protein mutations. It is therefore essential to develop evolutionary models capable of continuously…

Quantitative Methods · Quantitative Biology 2025-10-06 Liaofu Luo , Jun Lv

The amount of sequencing data for SARS-CoV-2 is several orders of magnitude larger than any virus. This will continue to grow geometrically for SARS-CoV-2, and other viruses, as many countries heavily finance genomic surveillance efforts.…

Genomics · Quantitative Biology 2023-04-10 Sarwan Ali , Prakash Chourasia , Zahra Tayebi , Babatunde Bello , Murray Patterson

In late 2019, a novel coronavirus, the SARS-CoV-2 outbreak was identified in Wuhan, China and later spread to every corner of the globe. Whilst the number of infection-induced deaths in Ghana, West Africa are minimal when compared with the…

Populations and Evolution · Quantitative Biology 2021-02-08 Edward Acheampong , Eric Okyere , Samuel Iddi , Joseph H. K. Bonney , Jonathan A. D. Wattis , Rachel L. Gomes

In this paper, we estimate the seroprevalence against COVID-19 by country and derive the seroprevalence over the world. To estimate seroprevalence, we use serological surveys (also called the serosurveys) conducted within each country. When…

Applications · Statistics 2022-02-01 Kwangmin Lee , Seongmin Kim , Seongil Jo , Jaeyong Lee

During the SARS-CoV-2 pandemic, wastewater-based genomic surveillance (WWGS) emerged as an efficient viral surveillance tool that takes into account asymptomatic cases and can identify known and novel mutations and offers the opportunity to…

The increasing spread of COVID-19, caused by the virus SARS-CoV-2, raises concerns about the extent to which mutations have occurred across the viral genome. We present a partial replication of an earlier 2021 study by Wang, R. et al. that…

Genomics · Quantitative Biology 2021-12-28 William Svoboda , Brendan McManamon , Sara Schwartz