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Attrition is a common and potentially important threat to internal validity in treatment effect studies. We extend the changes-in-changes approach to identify the average treatment effect for respondents and the entire study population in…

Econometrics · Economics 2024-03-29 Dalia Ghanem , Sarojini Hirshleifer , Désiré Kédagni , Karen Ortiz-Becerra

Leveraging external controls -- relevant individual patient data under control from external trials or real-world data -- has the potential to reduce the cost of randomized controlled trials (RCTs) while increasing the proportion of trial…

Methodology · Statistics 2022-07-13 Yanyao Yi , Ying Zhang , Yu Du , Ting Ye

We consider time to treatment initiation. This can commonly occur in preventive medicine, such as disease screening and vaccination; it can also occur with non-fatal health conditions such as HIV infection without the onset of AIDS. While…

Methodology · Statistics 2026-05-29 Zhichen Zhao , Andrew Ying , Ronghui Xu

Although deep learning (DL) models have shown great success in many medical image analysis tasks, deployment of the resulting models into real clinical contexts requires: (1) that they exhibit robustness and fairness across different…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Raghav Mehta , Changjian Shui , Tal Arbel

Kaplan-Meier survival analysis represents the most objective measure of treatment efficacy in oncology, though subjected to potential bias, which is worrisome in an era of precision medicine. Independent of the bias inherent to the design…

Methodology · Statistics 2020-12-17 Enrique Barrajón , Laura Barrajón

The present study performs a comprehensive fairness analysis of machine learning (ML) models for the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) from MRI-derived neuroimaging features. Biases associated with…

Machine Learning · Computer Science 2025-05-30 Maria Eleftheria Vlontzou , Maria Athanasiou , Christos Davatzikos , Konstantina S. Nikita

Background: The worst outcomes of diabetic retinopathy (DR) can be prevented by implementing DR screening programs assisted by AI. At the University Hospital of Navarre (HUN), Spain, general practitioners (GPs) grade fundus images in an…

Image and Video Processing · Electrical Eng. & Systems 2024-12-20 Imanol Pinto , Álvaro Olazarán , David Jurío , Borja de la Osa , Miguel Sainz , Aritz Oscoz , Jerónimo Ballaz , Javier Gorricho , Mikel Galar , José Andonegui

In industry, online randomized controlled experiment (a.k.a. A/B experiment) is a standard approach to measure the impact of a causal change. These experiments have small treatment effect to reduce the potential blast radius. As a result,…

Econometrics · Economics 2025-05-29 Tanmoy Das , Dohyeon Lee , Arnab Sinha

This paper analyzes the equilibrium of insurance market in a dynamic setting, focusing on the interaction between insurers' underwriting and investment strategies. Three possible equilibrium outcomes are identified: a positive insurance…

Theoretical Economics · Economics 2025-04-11 Bingzheng Chen , Zongxia Liang , Shunzhi Pang

We discovered secular trend bias in a drug effectiveness study for a recently approved drug. We compared treatment outcomes between patients who received the newly approved drug and patients exposed to the standard treatment. All patients…

Machine Learning · Computer Science 2018-08-21 Sharon Hensley Alford , Piyush Madan , Shilpa Mahatma , Italo Buleje , Yanyan Han , Fang Lu

Objective: To estimate the relationship between a hospital data breach and hospital quality outcome Materials and Methods: Hospital data breaches reported to the U.S. Department of Health and Human Services breach portal and the Privacy…

General Economics · Economics 2019-04-04 Sung J. Choi , M. Eric Johnson

Fairness has become increasingly pivotal in medical image recognition. However, without mitigating bias, deploying unfair medical AI systems could harm the interests of underprivileged populations. In this paper, we observe that while…

Computer Vision and Pattern Recognition · Computer Science 2024-02-21 Ching-Hao Chiu , Hao-Wei Chung , Yu-Jen Chen , Yiyu Shi , Tsung-Yi Ho

The Oregon Health Insurance Experiment (OHIE) offers a unique opportunity to examine the causal relationship between Medicaid coverage and happiness among low-income adults, using an experimental design. This study leverages data from…

General Economics · Economics 2025-10-17 Yangyang Li

This review paper explores recent advances in deep learning approaches for non-invasive cognitive impairment detection. We examine various non-invasive indicators of cognitive decline, including speech and language, facial, and motoric…

Machine Learning · Computer Science 2025-04-16 Muath Alsuhaibani , Ali Pourramezan Fard , Jian Sun , Farida Far Poor , Peter S. Pressman , Mohammad H. Mahoor

Suppression of disability progression is an important goal in the treatment of multiple sclerosis (MS). Randomized clinical trials in MS frequently use the time to the first confirmed disability progression (CDP) on the ordinal Expanded…

Applications · Statistics 2021-11-04 Alexandra Būhler

With the increasing frequency of major natural disasters, understanding their political consequences is of paramount importance for democratic accountability. The existing literature is deeply divided, with some studies finding that voters…

General Economics · Economics 2025-07-22 Nima Taheri Hosseinkhani

In aims to uncover insights into medical decision-making embedded within observational data from clinical settings, we present a novel application of Inverse Reinforcement Learning (IRL) that identifies suboptimal clinician actions based on…

In medical and epidemiological studies, one of the most common settings is studying the effect of a treatment on a time-to-event outcome, where the time-to-event might be censored before end of study. A common parameter of interest in such…

Methodology · Statistics 2024-02-15 Guilherme W. F. Barros , Jenny Häggström

We consider the challenges associated with causal inference in settings where data from a randomized trial is augmented with control data from an external source to improve efficiency in estimating the average treatment effect (ATE).…

As the COVID-19 pandemic restrictions slow down, employees start to return to their offices. Hence, the discussions on optimal workplaces and issues of diversity and inclusion have peaked. Previous research has shown that employees and…

Portfolio Management · Quantitative Finance 2022-11-08 Karoline Bax