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Individual-specific, time-constant, random effects are often used to model dependence and/or to account for omitted covariates in regression models for longitudinal responses. Longitudinal studies have known a huge and widespread use in the…

Methodology · Statistics 2026-01-14 Marco Alfo' , Roberto Rocci

In medical domain, data features often contain missing values. This can create serious bias in the predictive modeling. Typical standard data mining methods often produce poor performance measures. In this paper, we propose a new method to…

Machine Learning · Statistics 2015-03-24 Talayeh Razzaghi , Oleg Roderick , Ilya Safro , Nick Marko

Time series prediction with missing values is an important problem of time series analysis since complete data is usually hard to obtain in many real-world applications. To model the generation of time series, autoregressive (AR) model is a…

Machine Learning · Statistics 2019-08-28 Xi Chen , Hongzhi Wang , Yanjie Wei , Jianzhong Li , Hong Gao

Joint models have proven to be an effective approach for uncovering potentially hidden connections between various types of outcomes, mainly continuous, time-to-event, and binary. Typically, longitudinal continuous outcomes are…

This paper introduces the R package INLAjoint, designed as a toolbox for fitting a diverse range of regression models addressing both longitudinal and survival outcomes. INLAjoint relies on the computational efficiency of the integrated…

Methodology · Statistics 2024-04-04 Denis Rustand , Janet van Niekerk , Elias Teixeira Krainski , Håvard Rue

Joint models (JM) for longitudinal and survival data have gained increasing interest and found applications in a wide range of clinical and biomedical settings. These models facilitate the understanding of the relationship between outcomes…

Methodology · Statistics 2023-08-25 Sida Chen , Danilo Alvares , Christopher Jackson , Jessica Barrett

Missing data arises when certain values are not recorded or observed for variables of interest. However, most of the statistical theory assume complete data availability. To address incomplete databases, one approach is to fill the gaps…

Dynamic prediction of time-to-event outcomes using longitudinal data is highly useful in clinical research and practice. A common strategy is the joint modeling of longitudinal and time-to-event data. The shared random effect model has been…

Methodology · Statistics 2025-05-27 Wenhao Li , Zhe Yin , Liang Li

Dynamic prediction of causal effects under different treatment regimes conditional on an individual's characteristics and longitudinal history is an essential problem in precision medicine. This is challenging in practice because outcomes…

Methodology · Statistics 2023-03-07 Yizhen Xu , Jisoo Kim , Laura K. Hummers , Ami A. Shah , Scott Zeger

In some multivariate problems with missing data, pairs of variables exist that are never observed together. For example, some modern biological tools can produce data of this form. As a result of this structure, the covariance matrix is…

Methodology · Statistics 2013-08-13 Max Grazier G'Sell , Shai S. Shen-Orr , Robert Tibshirani

Randomized controlled trials (RCTs) are the accepted standard for treatment effect estimation but they can be infeasible due to ethical reasons and prohibitive costs. Single-arm trials, where all patients belong to the treatment group, can…

G-formula is a popular approach for estimating treatment or exposure effects from longitudinal data that are subject to time-varying confounding. G-formula estimation is typically performed by Monte-Carlo simulation, with non-parametric…

Simulation studies are commonly used in methodological research for the empirical evaluation of data analysis methods. They generate artificial data sets under specified mechanisms and compare the performance of methods across conditions.…

Methodology · Statistics 2025-07-11 Samuel Pawel , František Bartoš , Björn S. Siepe , Anna Lohmann

There is an emerging trend in the reinforcement learning for healthcare literature. In order to prepare longitudinal, irregularly sampled, clinical datasets for reinforcement learning algorithms, many researchers will resample the time…

Machine Learning · Computer Science 2019-11-19 Scott L. Fleming , Kuhan Jeyapragasan , Tony Duan , Daisy Ding , Saurabh Gombar , Nigam Shah , Emma Brunskill

Missing data is a common problem in medical research, and is commonly addressed using multiple imputation. Although traditional imputation methods allow for valid statistical inference when data are missing at random (MAR), their…

Irregular multivariate time series with missing values present significant challenges for predictive modeling in domains such as healthcare. While deep learning approaches often focus on temporal interpolation or complex architectures to…

Machine Learning · Computer Science 2026-03-16 Dingyi Nie , Yixing Wu , C. -C. Jay Kuo

In various data situations joint models are an efficient tool to analyze relationships between time dependent covariates and event times or to correct for event-dependent dropout occurring in regression analysis. Joint modeling connects a…

Methodology · Statistics 2018-10-25 Colin Griesbach , Andreas Mayr , Elisabeth Waldmann

Sensitivity analysis is popular in dealing with missing data problems particularly for non-ignorable missingness. It analyses how sensitively the conclusions may depend on assumptions about missing data e.g. missing data mechanism (MDM). We…

Methodology · Statistics 2015-01-26 Peng Yin , Jian Qing Shi

Time series imputation is one of the most challenge problems and has broad applications in various fields like health care and the Internet of Things. Existing methods mainly aim to model the temporally latent dependencies and the…

Machine Learning · Computer Science 2025-05-13 Ruichu Cai , Kaitao Zheng , Junxian Huang , Zijian Li , Zhengming Chen , Boyan Xu , Zhifeng Hao

Due to the cost or interference of measurement, we need to control measurement system. Assuming that each variable can be measured sequentially, there exists optimal policy choosing next measurement for the former observations. Though…

Machine Learning · Computer Science 2022-04-11 Seongwook Yoon , Jaehyun Kim , Heejeong Lim , Sanghoon Sull