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Joint modelling of longitudinal and time-to-event data has received much attention recently. Increasingly, extensions to standard joint modelling approaches are being proposed to handle complex data structures commonly encountered in…

Multivariate time series (MTS) forecasting is widely used in various domains, such as meteorology and traffic. Due to limitations on data collection, transmission, and storage, real-world MTS data usually contains missing values, making it…

Machine Learning · Computer Science 2019-11-26 Xianfeng Tang , Huaxiu Yao , Yiwei Sun , Charu Aggarwal , Prasenjit Mitra , Suhang Wang

Joint models for longitudinal and time-to-event data are widely used in many disciplines. Nonetheless, existing model comparison criteria do not indicate whether a model adequately fits the data or which components may be misspecified. We…

Methodology · Statistics 2026-01-27 Dimitris Rizopoulos , Jeremy M. G. Taylor , Isabella Kardys

A large amount of data is typically collected during a periodontal exam. Analyzing these data poses several challenges. Several types of measurements are taken at many locations throughout the mouth. These spatially-referenced data are a…

Applications · Statistics 2010-10-08 Brian J. Reich , Dipankar Bandyopadhyay

The analysis of randomized trials is often complicated by the occurrence of intercurrent events and missing values. Even though there are different strategies to address missing values it is still common to require missing values…

Methodology · Statistics 2025-11-11 A. Ruiz de Villa , Ll. Badiella

The problem of missing data, usually absent incurated and competition-standard datasets, is an unfortunate reality for most machine learning models used in industry applications. Recent work has focused on understanding the nature and the…

Machine Learning · Computer Science 2022-01-25 Spyridon Mouselinos , Kyriakos Polymenakos , Antonis Nikitakis , Konstantinos Kyriakopoulos

Stepped wedge cluster-randomized trial (CRTs) designs randomize clusters of individuals to intervention sequences, ensuring that every cluster eventually transitions from a control period to receive the intervention under study by the end…

Regular medical records are useful for medical practitioners to analyze and monitor patient health status especially for those with chronic disease, but such records are usually incomplete due to unpunctuality and absence of patients. In…

In biomedical studies it is common to collect data on multiple biomarkers during study follow-up for dynamic prediction of a time-to-event clinical outcome. The biomarkers are typically intermittently measured, missing at some event times,…

Methodology · Statistics 2021-07-05 Ning Li , Yi Liu , Shanpeng Li , Robert M. Elashoff , Gang Li

Modern datasets commonly feature both substantial missingness and many variables of mixed data types, which present significant challenges for estimation and inference. Complete case analysis, which proceeds using only the observations with…

Methodology · Statistics 2023-04-10 Joseph Feldman , Daniel R. Kowal

Deep Learning (DL) methods have dramatically increased in popularity in recent years, with significant growth in their application to supervised learning problems in the biomedical sciences. However, the greater prevalence and complexity of…

Machine Learning · Statistics 2023-10-30 David K Lim , Naim U Rashid , Junier B Oliva , Joseph G Ibrahim

Missing values frequently arise in modern biomedical studies due to various reasons, including missing tests or complex profiling technologies for different omics measurements. Missing values can complicate the application of clustering…

Machine Learning · Statistics 2019-02-27 Shahin Boluki , Siamak Zamani Dadaneh , Xiaoning Qian , Edward R. Dougherty

This paper tackles the problem of robust covariance matrix estimation when the data is incomplete. Classical statistical estimation methodologies are usually built upon the Gaussian assumption, whereas existing robust estimation ones assume…

Motivated by recent findings that within-subject (WS) visit-to-visit variabilities of longitudinal biomarkers can be strong risk factors for health outcomes, this paper introduces and examines a new joint model of a longitudinal biomarker…

Observational longitudinal data on treatments and covariates are increasingly used to investigate treatment effects, but are often subject to time-dependent confounding. Marginal structural models (MSMs), estimated using inverse probability…

Methodology · Statistics 2020-02-11 Ruth H. Keogh , Shaun R. Seaman , Jon Michael Gran , Stijn Vansteelandt

Multivariate time series data for real-world applications typically contain a significant amount of missing values. The dominant approach for classification with such missing values is to impute them heuristically with specific values…

Machine Learning · Computer Science 2023-08-15 SeungHyun Kim , Hyunsu Kim , EungGu Yun , Hwangrae Lee , Jaehun Lee , Juho Lee

Missingness is a common occurrence in educational assessment and psychological measurement. It could not be casually ignored as it may threaten the validity of the test if not handled properly. Considering the difference between omitted and…

Methodology · Statistics 2019-04-09 Jinxin Guo

Joint modeling of longitudinal and survival data has become increasingly important in medical research, particularly for understanding disease progression in chronic conditions where both repeated biomarker measurements and time-to-event…

Methodology · Statistics 2025-12-30 Nithisha Suryadevara , Vivek Reddy Srigiri

Techniques such as clusterization, neural networks and decision making usually rely on algorithms that are not well suited to deal with missing values. However, real world data frequently contains such cases. The simplest solution is to…

Machine Learning · Computer Science 2016-08-16 Davi E. N. Frossard , Igor O. Nunes , Renato A. Krohling

An approach to amputation, the process of introducing missing values to a complete dataset, is presented. It allows to construct missingness indicators in a flexible and principled way via copulas and Bernoulli margins and to incorporate…

Applications · Statistics 2025-07-28 Marius Hofert , James Jackson , Niels Hagenbuch