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Carcinogenesis is a proteiform phenomenon, with tumors emerging in various locations and displaying complex, diverse shapes. At the crucial intersection of research and clinical practice, it demands precise and flexible assessment. However,…

Background: Apparent Diffusion Coefficient (ADC) values and Total Diffusion Volume (TDV) from Whole-body diffusion-weighted MRI (WB-DWI) are recognized cancer imaging biomarkers. However, manual disease delineation for ADC and TDV…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 A. Candito , A. Dragan , R. Holbrey , A. Ribeiro , R. Donners , C. Messiou , N. Tunariu , D. -M. Koh , M. D. Blackledge

Automatic image annotation has been an important research topic in facilitating large scale image management and retrieval. Existing methods focus on learning image-tag correlation or correlation between tags to improve annotation accuracy.…

Computer Vision and Pattern Recognition · Computer Science 2018-01-01 Jiren Jin , Hideki Nakayama

Artificial intelligence (AI) has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images (WSIs). However, current methods are computationally inefficient, processing thousands of redundant…

In recent years, deep learning has successfully been applied to automate a wide variety of tasks in diagnostic histopathology. However, fast and reliable localization of small-scale regions-of-interest (ROI) has remained a key challenge, as…

Image and Video Processing · Electrical Eng. & Systems 2022-01-06 Jon Braatz , Pranav Rajpurkar , Stephanie Zhang , Andrew Y. Ng , Jeanne Shen

We introduce Fluid Annotation, an intuitive human-machine collaboration interface for annotating the class label and outline of every object and background region in an image. Fluid annotation is based on three principles: (I) Strong…

Computer Vision and Pattern Recognition · Computer Science 2018-12-21 Mykhaylo Andriluka , Jasper R. R. Uijlings , Vittorio Ferrari

Manually annotated data is key to developing text-mining and information-extraction algorithms. However, human annotation requires considerable time, effort and expertise. Given the rapid growth of biomedical literature, it is paramount to…

Human-Computer Interaction · Computer Science 2020-04-27 Rezarta Islamaj , Dongseop Kwon , Sun Kim , Zhiyong Lu

In recent years, the integration of advanced imaging techniques and deep learning methods has significantly advanced computer-aided diagnosis (CAD) systems for breast cancer detection and classification. Transformers, which have shown great…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Mahtab Ranjbar , Mehdi Mohebbi , Mahdi Cherakhloo , Bijan Vosoughi. Vahdat

Fine-grained Entity Typing is a tough task which suffers from noise samples extracted from distant supervision. Thousands of manually annotated samples can achieve greater performance than millions of samples generated by the previous…

Artificial Intelligence · Computer Science 2019-06-14 Sheng Lin , Luye Zheng , Bo Chen , Siliang Tang , Yueting Zhuang , Fei Wu , Zhigang Chen , Guoping Hu , Xiang Ren

Whole slide images (WSI) are microscopy images of stained tissue slides routinely prepared for diagnosis and treatment selection in medical practice. WSI are very large (gigapixel size) and complex (made of up to millions of cells). The…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tristan Lazard , Marvin Lerousseau , Etienne Decencière , Thomas Walter

Weak labeling is a popular weak supervision strategy for Named Entity Recognition (NER) tasks, with the goal of reducing the necessity for hand-crafted annotations. Although there are numerous remarkable annotation tools for NER labeling,…

Computation and Language · Computer Science 2025-07-04 Mengyang Liu , Haozheng Luo , Leonard Thong , Yinghao Li , Chao Zhang , Le Song

Whole slide image (WSI) analysis in digital pathology presents unique challenges due to the gigapixel resolution of WSIs and the scarcity of dense supervision signals. While Multiple Instance Learning (MIL) is a natural fit for slide-level…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Sofiène Boutaj , Marin Scalbert , Pierre Marza , Florent Couzinie-Devy , Maria Vakalopoulou , Stergios Christodoulidis

Histopathology Whole Slide Image (WSI) analysis serves as the gold standard for clinical cancer diagnosis in the daily routines of doctors. To develop computer-aided diagnosis model for WSIs, previous methods typically employ Multi-Instance…

Computer Vision and Pattern Recognition · Computer Science 2024-10-21 Honglin Li , Yunlong Zhang , Pingyi Chen , Zhongyi Shui , Chenglu Zhu , Lin Yang

This thesis work falls within the framework of question answering (QA) in the biomedical domain where several specific challenges are addressed, such as specialized lexicons and terminologies, the types of treated questions, and the…

Computation and Language · Computer Science 2023-07-26 Mourad Sarrouti

Whole Slide Images (WSI), obtained by high-resolution digital scanning of microscope slides at multiple scales, are the cornerstone of modern Digital Pathology. However, they represent a particular challenge to AI-based/AI-mediated analysis…

Computer Vision and Pattern Recognition · Computer Science 2024-04-12 Martim Afonso , Praphulla M. S. Bhawsar , Monjoy Saha , Jonas S. Almeida , Arlindo L. Oliveira

Two of the most common tasks in medical imaging are classification and segmentation. Either task requires labeled data annotated by experts, which is scarce and expensive to collect. Annotating data for segmentation is generally considered…

Computer Vision and Pattern Recognition · Computer Science 2020-12-01 Ozan Ciga , Anne L. Martel

Deep-learning-based approaches for retinal lesion segmentation often require an abundant amount of precise pixel-wise annotated data. However, coarse annotations such as circles or ellipses for outlining the lesion area can be six times…

Computer Vision and Pattern Recognition · Computer Science 2022-08-31 Qinji Yu , Kang Dang , Ziyu Zhou , Yongwei Chen , Xiaowei Ding

Accurately estimating the wiring diagram of a brain, known as a connectome, at an ultrastructure level is an open research problem. Specifically, precisely tracking neural processes is difficult, especially across many image slices. Here,…

Computer Vision and Pattern Recognition · Computer Science 2014-05-09 Ayushi Sinha , William Gray Roncal , Narayanan Kasthuri , Jeff W. Lichtman , Randal Burns , Michael Kazhdan

Histopathology image analysis plays a crucial role in cancer diagnosis. However, training a clinically applicable segmentation algorithm requires pathologists to engage in labour-intensive labelling. In contrast, weakly supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Gang Xu , Shuhao Wang , Lingyu Zhao , Xiao Chen , Tongwei Wang , Lang Wang , Zhenwei Luo , Dahan Wang , Zewen Zhang , Aijun Liu , Wei Ba , Zhigang Song , Huaiyin Shi , Dingrong Zhong , Jianpeng Ma

Gate-defined semiconductor quantum dot (QD) arrays are a promising platform for quantum computing. However, presently, the large configuration spaces and inherent noise make tuning of QD devices a nontrivial task and with the increasing…

Mesoscale and Nanoscale Physics · Physics 2023-12-19 Brian Weber , Justyna P. Zwolak