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Deep learning has greatly advanced medical image segmentation, but its success relies heavily on fully supervised learning, which requires dense annotations that are costly and time-consuming for 3D volumetric scans. Barely-supervised…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Shuang Zeng , Boxu Xie , Lei Zhu , Xinliang Zhang , Jiakui Hu , Zhengjian Yao , Yuanwei Li , Yuxing Lu , Yanye Lu

Whole Slide Image (WSI) analysis, with its ability to reveal detailed tissue structures in magnified views, plays a crucial role in cancer diagnosis and prognosis. Due to their giga-sized nature, WSIs require substantial storage and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Doanh Cao Bui , Jin Tae Kwak

In recent years, deep learning (DL) methods have become powerful tools for biomedical image segmentation. However, high annotation efforts and costs are commonly needed to acquire sufficient biomedical training data for DL models. To…

Computer Vision and Pattern Recognition · Computer Science 2018-06-05 Lin Yang , Yizhe Zhang , Zhuo Zhao , Hao Zheng , Peixian Liang , Michael T. C. Ying , Anil T. Ahuja , Danny Z. Chen

The field of computational pathology has witnessed great advancements since deep neural networks have been widely applied. These networks usually require large numbers of annotated data to train vast parameters. However, it takes…

Computer Vision and Pattern Recognition · Computer Science 2022-08-11 Yixiao Zhang , Adam Kortylewski , Qing Liu , Seyoun Park , Benjamin Green , Elizabeth Engle , Guillermo Almodovar , Ryan Walk , Sigfredo Soto-Diaz , Janis Taube , Alex Szalay , Alan Yuille

Cancer detection and classification from gigapixel whole slide images of stained tissue specimens has recently experienced enormous progress in computational histopathology. The limitation of available pixel-wise annotated scans shifted the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-30 Mehdi Naouar , Gabriel Kalweit , Ignacio Mastroleo , Philipp Poxleitner , Marc Metzger , Joschka Boedecker , Maria Kalweit

Organ-at-risk contouring is still a bottleneck in radiotherapy, with many deep learning methods falling short of promised results when evaluated on clinical data. We investigate the accuracy and time-savings resulting from the use of an…

Computer Vision and Pattern Recognition · Computer Science 2022-04-06 Abraham George Smith , Jens Petersen , Cynthia Terrones-Campos , Anne Kiil Berthelsen , Nora Jarrett Forbes , Sune Darkner , Lena Specht , Ivan Richter Vogelius

Automatic image-based severity estimation is an important task in computer-aided diagnosis. Severity estimation by deep learning requires a large amount of training data to achieve a high performance. In general, severity estimation uses…

Computer Vision and Pattern Recognition · Computer Science 2024-09-11 Takeaki Kadota , Hideaki Hayashi , Ryoma Bise , Kiyohito Tanaka , Seiichi Uchida

Medical image annotation is essential for diagnosing diseases, yet manual annotation is time-consuming, costly, and prone to variability among experts. To address these challenges, we propose an automated explainable annotation system that…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Basma Nasir , Tehseen Zia , Muhammad Nawaz , Catarina Moreira

Deep learning classifiers for characterization of whole slide tissue morphology require large volumes of annotated data to learn variations across different tissue and cancer types. As is well known, manual generation of digital pathology…

Image and Video Processing · Electrical Eng. & Systems 2019-07-10 Shahira Abousamra , Le Hou , Rajarsi Gupta , Chao Chen , Dimitris Samaras , Tahsin Kurc , Rebecca Batiste , Tianhao Zhao , Shroyer Kenneth , Joel Saltz

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Deep neural networks deliver state-of-the-art visual recognition, but they rely on large datasets, which are time-consuming to annotate. These datasets are typically annotated in two stages: (1) determining the presence of object classes at…

Computer Vision and Pattern Recognition · Computer Science 2019-12-20 Michael Gygli , Vittorio Ferrari

Whole slide imaging is routinely adopted for carcinoma diagnosis and prognosis. Abundant experience is required for pathologists to achieve accurate and reliable diagnostic results of whole slide images (WSI). The huge size and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Pingyi Chen , Chenglu Zhu , Sunyi Zheng , Honglin Li , Lin Yang

In pre-clinical pathology, there is a paradox between the abundance of raw data (whole slide images from many organs of many individual animals) and the lack of pixel-level slide annotations done by pathologists. Due to time constraints and…

Computer Vision and Pattern Recognition · Computer Science 2023-02-06 Marco Bertolini , Van-Khoa Le , Jake Pencharz , Andreas Poehlmann , Djork-Arné Clevert , Santiago Villalba , Floriane Montanari

Mask-based annotation of medical images, especially for 3D data, is a bottleneck in developing reliable machine learning models. Using minimal-labor user interactions (UIs) to guide the annotation is promising, but challenges remain on best…

Computer Vision and Pattern Recognition · Computer Science 2020-09-08 Ashwin Raju , Zhanghexuan Ji , Chi Tung Cheng , Jinzheng Cai , Junzhou Huang , Jing Xiao , Le Lu , ChienHung Liao , Adam P. Harrison

Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase commercial…

There is a dire need for medical imaging datasets with accompanying annotations to perform downstream patient analysis. However, it is difficult to manually generate these annotations, due to the time-consuming nature, and the variability…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Deepa Krishnaswamy , Vamsi Krishna Thiriveedhi , Cosmin Ciausu , David Clunie , Steve Pieper , Ron Kikinis , Andrey Fedorov

Image annotation is one essential prior step to enable data-driven algorithms. In medical imaging, having large and reliably annotated data sets is crucial to recognize various diseases robustly. However, annotator performance varies…

Image and Video Processing · Electrical Eng. & Systems 2022-11-23 Sonja Kunzmann , Mathias Öttl , Prathmesh Madhu , Felix Denzinger , Andreas Maier

The work discusses the use of machine learning algorithms for anomaly detection in medical image analysis and how the performance of these algorithms depends on the number of annotators and the quality of labels. To address the issue of…

Computer Vision and Pattern Recognition · Computer Science 2023-03-30 Hieu H. Pham , Khiem H. Le , Tuan V. Tran , Ha Q. Nguyen

Nodule segmentation from breast ultrasound images is challenging yet essential for the diagnosis. Weakly-supervised segmentation (WSS) can help reduce time-consuming and cumbersome manual annotation. Unlike existing weakly-supervised…

Computer Vision and Pattern Recognition · Computer Science 2021-08-03 Yuhao Huang , Xin Yang , Yuxin Zou , Chaoyu Chen , Jian Wang , Haoran Dou , Nishant Ravikumar , Alejandro F Frangi , Jianqiao Zhou , Dong Ni

Segmentation and classification of large numbers of instances, such as cell nuclei, are crucial tasks in digital pathology for accurate diagnosis. However, the availability of high-quality datasets for deep learning methods is often limited…

Computer Vision and Pattern Recognition · Computer Science 2024-10-21 Laura Gálvez Jiménez , Christine Decaestecker
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