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During embryonic morphogenesis, tissues undergo dramatic deformations in order to form functional organs. Similarly, in adult animals, living cells and tissues are continually subjected to forces and deformations. Therefore, the success of…
Mathematical models of biological growth commonly attempt to distinguish deformation due to growth from that due to mechanical stresses through a hypothesised multiplicative decomposition of the deformation gradient. Here we demonstrate…
Structural resonance involves the absorption of inertial loads by a tuned structural elasticity: a process playing a key role in a wide range of biological and technological systems, including many biological and bio-inspired locomotion…
Patient-specific computational models of the heart are powerful tools for cardiovascular research and medicine, with demonstrated applications in treatment planning, device evaluation, and surgical decision-making. Yet constructing such…
Bone remodeling is a complex process involving cell-cell interactions, biochemical signaling and mechanical stimuli. Early models of the biological aspects of remodeling were non-spatial and focused on the local dynamics at a fixed location…
The ability to design and fabricate materials with tailored mechanical properties, combined with immunity to damage, is a frontier of materials engineering. For example, materials which are characterized by elastic properties that depend on…
Mechanical signaling plays a key role in biological processes like embryo development and cancer growth. One prominent way to probe mechanical properties of tissues is to study their response to externally applied forces. Using a…
A stable shape for corneas experiencing refractive surgery has to be sustained so as to elude post-refractive surgery de-compensation. This de-compensation leads to visual complications and unsatisfactory procedure recovery. Variation in…
Mechanical properties are intrinsically related to the structures and dynamics of systems. The main tools to investigate mechanical properties are rheology and microrheology. Those techniques can focus on the macroscopic and microscopic…
A new class of micromechanically motivated chain network models for soft biological tissues is presented. On the microlevel, it is based on the statistics of long chain molecules. A wormlike chain model is applied to capture the behavior of…
The classical flexure problem of non-linear incompressible elasticity is revisited for elastic materials whose mechanical response is different in tension and compression---the so-called bimodular materials. The flexure problem is chosen to…
Biological adhesion is a critical mechanical function of complex organisms operating at multiple scales. At the cellular scale, cell-cell adhesion is remarkably tunable to enable both cohesion and malleability during development,…
Inelastic mechanical responses in solids, such as plasticity, damage and crack initiation, are typically modeled in constitutive ways that display microstructural and loading dependence. Nevertheless, {linear} elasticity at infinitesimal…
Neurological injuries and age-related decline can impair sensory processing and disrupt motor coordination, gait, and balance. As mechanisms of neuroplasticity have become better understood, vibration-based interventions have gained…
The mechanics of biological tissues mainly proceeds from the cell cortex rheology. A direct, explicit link between cortex rheology and tissue rheology remains lacking, yet would be instrumental in understanding how modulations of cortical…
Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of…
Medical imaging is an invaluable resource in medicine as it enables to peer inside the human body and provides scientists and physicians with a wealth of information indispensable for understanding, modelling, diagnosis, and treatment of…
The rich novel materials class of iron based superconductors turned out to exhibit a very complex electronic structure, despite of the simplicity of their crystal structures. For various approaches to study the instability against magnetic…
Brittle materials fail catastrophically. In consequence of their limited flaw-tolerance, failure occurs by localized fracture and is typically a dynamic process. Recently, experiments on epithelial cell monolayers have revealed that this…
The mechanical properties of tissues play an essential role for all tissue properties such as cell division, and differentiation or morphogenesis. Here, we study theoretically the rheology of 2-dimensional epithelial tissues described by a…