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The structure of molecular networks derives from dynamical processes on evolutionary time scales. For protein interaction networks, global statistical features of their structure can now be inferred consistently from several…

Statistical Mechanics · Physics 2007-05-23 Johannes Berg , Michael Lässig , Andreas Wagner

Shaped by natural selection and other evolutionary forces, an organism's evolutionary history is reflected through its genome sequence, content of functional elements and organization. Consequently, organisms connected through phylogeny,…

Genomics · Quantitative Biology 2023-06-16 Serena Lam , Giorgio Gonnella

Evolution is often understood through genetic mutations driving changes in an organism's fitness, but there is potential to extend this understanding beyond the genetic code. We propose that natural products - complex molecules central to…

Populations and Evolution · Quantitative Biology 2024-09-11 Sebastian Pagel , Abhishek Sharma , Leroy Cronin

In the principles-and-parameters framework, the structural features of languages depend on parameters that may be toggled on or off, with a single parameter often dictating the status of multiple features. The implied covariance between…

Computation and Language · Computer Science 2019-05-16 Johannes Bjerva , Yova Kementchedjhieva , Ryan Cotterell , Isabelle Augenstein

Since the time of Darwin, scientists have struggled to reconcile the evolution of biological forms in a universe determined by fixed laws. These laws underpin the origin of life, evolution, human culture and technology, as set by the…

The classification of life should be based upon the fundamental mechanism in the evolution of life. We found that the global relationships among species should be circular phylogeny, which is quite different from the common sense based upon…

Genomics · Quantitative Biology 2009-12-16 Dirson Jian Li , Shengli Zhang

Just as physicists strive to develop a TOE (theory of everything), which explains and unifies the physical laws of the universe, the life-scientist wishes to uncover the TOE as it relates to cellular systems. This can only be achieved with…

Quantitative Methods · Quantitative Biology 2009-11-04 Kyung Dae Ko , Yoojin Hong , Gaurav Bhardwaj , Teresa M. Killick , Damian B. van Rossum , Randen L. Patterson

When we speak, write or listen, we continuously make predictions based on our knowledge of a language's grammar. Remarkably, children acquire this grammatical knowledge within just a few years, enabling them to understand and generalise to…

Computation and Language · Computer Science 2024-11-26 Jaap Jumelet

All living organisms use the same genetic languages in their molecular biology machinery. They can be understood as the optimal solutions to the replication tasks involving DNA and proteins. These solutions perfectly fit the pattern…

Other Quantitative Biology · Quantitative Biology 2025-05-21 Apoorva D. Patel

The present view of biological phenomena is based on a biochemical paradigm that development of living organisms is defined by information stored in a molecular form as some genetic code. However, new discoveries indicate that biological…

Other Quantitative Biology · Quantitative Biology 2023-11-14 Yuri K. Shestopaloff

There is an intrinsic relationship between the molecular evolution in primordial period and the properties of genomes and proteomes of contemporary species. The genomic data may help us understand the driving force of evolution of life at…

Genomics · Quantitative Biology 2009-11-25 Dirson Jian Li , Shengli Zhang

Languages and genes are both transmitted from generation to generation, with opportunity for differential reproduction and survivorship of forms. Here we apply a rigorous inference framework, drawn from population genetics, to distinguish…

Populations and Evolution · Quantitative Biology 2017-11-07 Christopher A. Ahern , Mitchell G. Newberry , Robin Clark , Joshua B. Plotkin

Biological systems reach organizational complexity that far exceeds the complexity of any known inanimate objects. Biological entities undoubtedly obey the laws of quantum physics and statistical mechanics. However, is modern physics…

Other Quantitative Biology · Quantitative Biology 2018-02-26 Mikhail I. Katsnelson , Yuri I. Wolf , Eugene V. Koonin

The next step in the understanding of the genome organization, after the determination of complete sequences, involves proteomics. The proteome includes the whole set of protein-protein interactions, and two recent independent studies have…

Statistical Mechanics · Physics 2007-05-23 Ricard V. Sole , Romualdo Pastor-Satorras , Eric Smith , Thomas B. Kepler

Many of life's most fascinating phenomena emerge from interactions among many elements--many amino acids determine the structure of a single protein, many genes determine the fate of a cell, many neurons are involved in shaping our thoughts…

Quantitative Methods · Quantitative Biology 2011-11-28 Thierry Mora , William Bialek

The evolution in coding DNA sequences brings new flexibility and freedom to the codon words, even as the underlying nucleotides get significantly ordered. These curious contra-rules of gene organisation are observed from the distribution of…

Biological Physics · Physics 2007-05-23 Sujay Chattopadhyay , William A. Kanner , Jayprokas Chakrabarti

A new account of parameter setting during grammatical acquisition is presented in terms of Generalized Categorial Grammar embedded in a default inheritance hierarchy, providing a natural partial ordering on the setting of parameters.…

cmp-lg · Computer Science 2008-02-03 Ted Briscoe

This paper attempts to connects the evolution of computer languages with the evolution of life, where the later has been dictated by \emph{theory of evolution of species}, and tries to give supportive evidence that the new languages are…

Programming Languages · Computer Science 2020-07-07 K. R. Chowdhary

Languages vary considerably in syntactic structure. About 40% of the world's languages have subject-verb-object order, and about 40% have subject-object-verb order. Extensive work has sought to explain this word order variation across…

Computation and Language · Computer Science 2022-06-10 Michael Hahn , Yang Xu

Understanding how cognitive and social mechanisms shape the evolution of complex artifacts such as songs is central to cultural evolution research. Social network topology (what artifacts are available?), selection (which are chosen?), and…

Social and Information Networks · Computer Science 2025-02-19 Raja Marjieh , Manuel Anglada-Tort , Thomas L. Griffiths , Nori Jacoby