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Our knowledge of the organisation of the human brain at the population-level is yet to translate into power to predict functional differences at the individual-level, limiting clinical applications, and casting doubt on the generalisability…

Neurons and Cognition · Quantitative Biology 2024-04-04 James K Ruffle , Robert J Gray , Samia Mohinta , Guilherme Pombo , Chaitanya Kaul , Harpreet Hyare , Geraint Rees , Parashkev Nachev

Background: Brain network models offer insights into brain dynamics, but the utility of model-derived bifurcation parameters as biomarkers remains underexplored. Objective: This study evaluates bifurcation parameters from a whole-brain…

Neurons and Cognition · Quantitative Biology 2025-11-26 Facundo Roffet , Gustavo Deco , Claudio Delrieux , Gustavo Patow

Understanding how the brain's complex nonlinear dynamics give rise to cognitive function remains a central challenge in neuroscience. While brain functional dynamics exhibits scale-free and multifractal properties across temporal scales,…

Neurons and Cognition · Quantitative Biology 2025-06-18 Sangyoon Bae , Junbeom Kwon , Shinjae Yoo , Jiook Cha

Sustainable research on computational models of neuronal networks requires published models to be understandable, reproducible, and extendable. Missing details or ambiguities about mathematical concepts and assumptions, algorithmic…

Predictive coding is an influential theory of cortical function which posits that the principal computation the brain performs, which underlies both perception and learning, is the minimization of prediction errors. While motivated by…

Neurons and Cognition · Quantitative Biology 2020-10-13 Beren Millidge , Alexander Tschantz , Anil Seth , Christopher L Buckley

Dynamic brain data, teeming with biological and functional insights, are becoming increasingly accessible through advanced measurements, providing a gateway to understanding the inner workings of the brain in living subjects. However, the…

Neurons and Cognition · Quantitative Biology 2025-08-19 Zixia Zhou , Junyan Liu , Wei Emma Wu , Ruogu Fang , Sheng Liu , Qingyue Wei , Rui Yan , Yi Guo , Qian Tao , Yuanyuan Wang , Md Tauhidul Islam , Lei Xing

It is essential to understand the complex structure of the human brain to develop new treatment approaches for neurodegenerative disorders (NDDs). This review paper comprehensively discusses the challenges associated with modelling the…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

Artificial Recurrent Neural Networks (RNNs) are widely used in neuroscience to model the collective activity of neurons during behavioral tasks. The high dimensionality of their parameter and activity spaces, however, often make it…

Dynamical Systems · Mathematics 2025-10-16 Alice Marraffa , Renate Krause , Valerio Mante , George Haller

It has been proposed that neural noise in the cortex arises from chaotic dynamics in the balanced state: in this model of cortical dynamics, the excitatory and inhibitory inputs to each neuron approximately cancel, and activity is driven by…

Disordered Systems and Neural Networks · Physics 2017-04-28 Nimrod Shaham , Yoram Burak

Neuronal ensemble activity, including coordinated and oscillatory patterns, exhibits hallmarks of nonequilibrium systems with time-asymmetric trajectories to maintain their organization. However, assessing time asymmetry from neuronal…

Neurons and Cognition · Quantitative Biology 2025-12-12 Ken Ishihara , Hideaki Shimazaki

Synaptic connections between neurons in the brain are dynamic because of continuously ongoing spine dynamics, axonal sprouting, and other processes. In fact, it was recently shown that the spontaneous synapse-autonomous component of spine…

Neurons and Cognition · Quantitative Biology 2018-01-08 David Kappel , Robert Legenstein , Stefan Habenschuss , Michael Hsieh , Wolfgang Maass

Understanding how large-scale functional brain networks reorganize during cognitive decline remains a central challenge in neuroimaging. While recent self-supervised models have shown promise for learning representations from resting-state…

Machine Learning · Computer Science 2026-03-03 Karanpartap Singh , Adam Turnbull , Mohammad Abbasi , Kilian Pohl , Feng Vankee Lin , Ehsan Adeli

The growing interest in brain-inspired computational models arises from the remarkable problem-solving efficiency of the human brain. Action recognition, a complex task in computational neuroscience, has received significant attention due…

Neural and Evolutionary Computing · Computer Science 2024-06-18 Alireza Nadafian , Milad Mozafari , Timothée Masquelier , Mohammad Ganjtabesh

In this paper, we propose a novel unsupervised learning method to learn the brain dynamics using a deep learning architecture named residual D-net. As it is often the case in medical research, in contrast to typical deep learning tasks, the…

Machine Learning · Statistics 2019-03-01 Youngjoo Seo , Manuel Morante , Yannis Kopsinis , Sergios Theodoridis

A complete understanding of the brain requires an integrated description of the numerous scales of neural organization. It means studying the interplay of genes, synapses, and even whole brain regions which ultimately leads to different…

Neurons and Cognition · Quantitative Biology 2022-08-09 Charley Presigny , Fabrizio De Vico Fallani

Neurons can display highly variable dynamics. While such variability presumably supports the wide range of behaviors generated by the organism, their gene expressions are relatively stable in the adult brain. This suggests that neuronal…

Neurons and Cognition · Quantitative Biology 2023-11-07 Lu Mi , Trung Le , Tianxing He , Eli Shlizerman , Uygar Sümbül

Highly correlated brain dynamics produces synchronized states with no behavioral value, while weakly correlated dynamics prevent information flow. In between these states, the unique dynamical features of the critical state endow the brain…

Neurons and Cognition · Quantitative Biology 2012-10-16 Dante R. Chialvo

When the human brain manifests the birth of organised communication among local and large-scale neuronal populations activity remains undescribed. We report, in resting-state EEG source-estimates of 100 infants at term age, the existence of…

Neurons and Cognition · Quantitative Biology 2020-09-08 Steve Mehrkanoon

The brain is a highly complex system. Most of such complexity stems from the intermingled connections between its parts, which give rise to rich dynamics and to the emergence of high-level cognitive functions. Disentangling the underlying…

Neurons and Cognition · Quantitative Biology 2023-08-14 Vito Dichio , Fabrizio De Vico Fallani

In recent years, there have been many computational simulations of spontaneous neural dynamics. Here, we explore a model of spontaneous neural dynamics and allow it to control a virtual agent moving in a simple environment. This setup…

Neurons and Cognition · Quantitative Biology 2016-08-19 Peter J. Hellyer , Claudia Clopath , Angie A. Kehagia , Federico E. Turkheimer , Robert Leech