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Following [Diggle 2011, Greenland 1995], we give a simple formula for the Bayesian posterior density of a prevalence parameter based on unreliable testing of a population. This problem is of particular importance when the false positive…

Applications · Statistics 2020-09-14 Jonathan Baxter

We present a method for efficient estimation of the prevalence of infection in a population with high accuracy using only a small number of tests. The presented approach uses pool testing with a mix of pool sizes of various sizes. The test…

Applications · Statistics 2020-04-08 Itsik Bergel

Respondent-driven sampling (RDS) is an approach to sampling design and analysis which utilizes the networks of social relationships that connect members of the target population, using chain-referral methods to facilitate sampling. RDS…

Methodology · Statistics 2015-08-19 Yakir Berchenko , Jonathan Rosenblatt , Simon D. W. Frost

Cross-sectional incidence estimation based on recency testing has become a widely used tool in HIV research. Recently, this method has gained prominence in HIV prevention trials to estimate the "placebo" incidence that participants might…

Methodology · Statistics 2024-12-18 Jianan Pan , Marlena Bannick , Fei Gao

Since the beginning of March 2020, the cumulative numbers of cases of infection with the novel coronavirus SARS-CoV-2 in Germany have been reported on a daily basis. The reports originate from national laws, according to which positive test…

Populations and Evolution · Quantitative Biology 2020-05-08 Ralph Brinks , Annika Hoyer

Network surveys of key populations at risk for HIV are an essential part of the effort to understand how the epidemic spreads and how it can be prevented. Estimation of population values from the sample data has been probematical, however,…

Applications · Statistics 2019-09-12 Steve Thompson

Intuitively, sampling is likely to be more efficient for prevalence estimation, if the cases (or positives) have a relatively higher representation in the sample than in the population. In case the virus is transmitted via personal…

Applications · Statistics 2020-11-18 Li-Chun Zhang

The new corona virus disease -- COVID-2019 -- is rapidly spreading through the world. The availability of unbiased timely statistics of trends in disease events are a key to effective responses. But due to reporting delays, the most…

Populations and Evolution · Quantitative Biology 2020-06-15 Adam Altmejd , Joacim Rocklöv , Jonas Wallin

The COVID-19 pandemic provides new motivation for a classic problem in epidemiology: estimating the empirical rate of transmission during an outbreak (formally, the time-varying reproduction number) from case counts. While standard methods…

Methodology · Statistics 2020-12-08 Bryan Wilder , Michael J. Mina , Milind Tambe

Pooled and individual disease testing are common methods for determining the population prevalences of diseases. Recently, researchers have used Monte Carlo Markov Chain methods to estimate population prevalence from the combined streams of…

Methodology · Statistics 2023-08-23 Matthew Ritch , Charles Copley

As a consequence of missing data on tests for infection and imperfect accuracy of tests, reported rates of population infection by the SARS CoV-2 virus are lower than actual rates of infection. Hence, reported rates of severe illness…

Econometrics · Economics 2020-04-27 Charles F. Manski , Francesca Molinari

Estimating the prevalence of a disease is necessary for evaluating and mitigating risks of its transmission within or between populations. Estimates that consider how prevalence changes with time provide more information about these risks…

Applications · Statistics 2021-11-12 Braden Scherting , Alison Peel , Raina Plowright , Andrew Hoegh

Based on the official data modeling, this paper studies the transmission process of the Corona Virus Disease 2019 (COVID-19). The error between the model and the official data curve is within 3%. At the same time, it realized forward…

Populations and Evolution · Quantitative Biology 2020-03-17 Lixiang Li , Zihang Yang , Zhongkai Dang , Cui Meng , Jingze Huang , Hao Tian Meng , Deyu Wang , Guanhua Chen , Jiaxuan Zhang , Haipeng Peng

During an infectious disease outbreak, public health decision-makers require real-time monitoring of disease transmission to respond quickly and intelligently. In these settings, a key measure of transmission is the instantaneous…

Methodology · Statistics 2025-02-07 Gary Hettinger , David Rubin , Jing Huang

The usual development cycles are too slow for the development of vaccines, diagnostics and treatments in pandemics such as the ongoing SARS-CoV-2 pandemic. Given the pressure in such a situation, there is a risk that findings of early…

Applications · Statistics 2020-10-12 Sarah Friedrich , Tim Friede

The estimation of unknown parameters in simulations, also known as calibration, is crucial for practical management of epidemics and prediction of pandemic risk. A simple yet widely used approach is to estimate the parameters by minimizing…

Methodology · Statistics 2023-06-26 Chih-Li Sung , Ying Hung

Timely prediction of the COVID-19 progression is not possible without a comprehensive understanding of environmental factors that may affect the infection transmissibility. Studies addressing parameters that may influence COVID-19…

Populations and Evolution · Quantitative Biology 2021-03-30 Igor Salom , Andjela Rodic , Ognjen Milicevic , Dusan Zigic , Magdalena Djordjevic , Marko Djordjevic

While COVID-19 has impacted humans for a long time, people search the web for pandemic-related information, causing anxiety. From a theoretic perspective, previous studies have confirmed that the number of COVID-19 cases can cause negative…

Computers and Society · Computer Science 2022-11-17 Linjiang Guo , Zijian Feng , Yuxue Chi , Mingzhu Wang , Yijun Liu

Estimates from infectious disease models have constituted a significant part of the scientific evidence used to inform the response to the COVID-19 pandemic in the UK. These estimates can vary strikingly in their bias and variability.…

Applications · Statistics 2022-10-12 R. E. Moore , C. Rosato , S. Maskell

COVID-19 pandemic has reshaped our world in a timescale much shorter than what we can understand. Particularities of SARS-CoV-2, such as its persistence in surfaces and the lack of a curative treatment or vaccine against COVID-19, have…