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Having accurate and timely data on confirmed active COVID-19 cases is challenging, since it depends on testing capacity and the availability of an appropriate infrastructure to perform tests and aggregate their results. In this paper, we…

We argue that frequent sampling of the fraction of infected people (either by random testing or by analysis of sewage water), is central to managing the COVID-19 pandemic because it both measures in real time the key variable controlled by…

Populations and Evolution · Quantitative Biology 2020-07-24 Markus Müller , Peter M. Derlet , Christopher Mudry , Gabriel Aeppli

Estimation of prevalence of undocumented SARS-CoV-2 infections is critical for understanding the overall impact of the Covid-19 disease. In fact, unveiling uncounted cases has fundamental implications for public policy interventions…

Physics and Society · Physics 2022-01-31 Luigi Palatella , Fabio Vanni , David Lambert

This paper describes types of errors arising in a recently proposed method of incidence estimation from prevalence data. The errors are illustrated by a simulation study about a hypothetical irreversible disease. In addition, a way of…

Populations and Evolution · Quantitative Biology 2014-10-06 Ralph Brinks

Prevalent cohort sampling is commonly used to study the natural history of a disease when the disease is rare or it usually takes a long time to observe the failure event. It is known, however, that the collected sample in this situation is…

Methodology · Statistics 2022-09-05 Omidali Aghababaei Jazi

The relative case fatality rates (CFRs) between groups and countries are key measures of relative risk that guide policy decisions regarding scarce medical resource allocation during the ongoing COVID-19 pandemic. In the middle of an active…

Quantitative Methods · Quantitative Biology 2022-12-08 Anastasios Nikolas Angelopoulos , Reese Pathak , Rohit Varma , Michael I. Jordan

Capture-recapture (CRC) surveys are used to estimate the size of a population whose members cannot be enumerated directly. CRC surveys have been used to estimate the number of Covid-19 infections, people who use drugs, sex workers, conflict…

Methodology · Statistics 2022-10-17 Jinghao Sun , Luk Van Baelen , Els Plettinckx , Forrest W. Crawford

During the current Covid-19 pandemic in Italy, official data are collected with medical swabs following a pure convenience criterion which, at least in an early phase, has privileged the exam of patients showing evident symptoms. However,…

Quantitative Methods · Quantitative Biology 2020-05-18 Francesca Bassi , Giuseppe Arbia , Pietro Demetrio Falorsi

We consider the problem of estimating the reproduction number $R_t$ of an epidemic for populations where the probability of detection of cases depends on a known covariate. We argue that in such cases the normal empirical estimator can fail…

Applications · Statistics 2020-12-04 Guido Sanguinetti

Nonprobability (convenience) samples are increasingly sought to reduce the estimation variance for one or more population variables of interest that are estimated using a randomized survey (reference) sample by increasing the effective…

Serology testing can identify past infection by quantifying the immune response of an infected individual providing important public health guidance. Individual immune responses are time-dependent, which is reflected in antibody…

Quantitative Methods · Quantitative Biology 2022-08-04 Prajakta Bedekar , Anthony J. Kearsley , Paul N. Patrone

Compartmental models are used in epidemiology to capture the evolution of infectious diseases such as COVID-19 in a population by assigning members of it to compartments with labels such as susceptible, infected, and recovered. In a…

Formal Languages and Automata Theory · Computer Science 2024-02-15 Tim Leys , Guillermo A. Perez

The role of epidemiological models is crucial for informing public health officials during a public health emergency, such as the COVID-19 pandemic. However, traditional epidemiological models fail to capture the time-varying effects of…

Methodology · Statistics 2022-06-17 Adam Spannaus , Theodore Papamarkou , Samantha Erwin , J. Blair Christian

Representative risk estimation is fundamental to clinical decision-making. However, risks are often estimated from non-representative epidemiologic studies, which usually underrepresent minorities. "Model-based" methods use population…

Methodology · Statistics 2023-04-12 Lingxiao Wang , Yan Li , Barry I. Graubard , Hormuzd A. Katki

Sample pooling consists in combining samples from multiple individuals into a single pool that is then tested using a unique test-kit. A positive test means that at least one individual within the pool is infected. Here, we propose an…

Quantitative Methods · Quantitative Biology 2021-03-18 Vincent Brault , Bastien Mallein , Jean-Francois Rupprecht

Longitudinal cohorts to determine the incidence of HIV infection are logistically challenging, so researchers have sought alternative strategies. Recency test methods use biomarker profiles of HIV-infected subjects in a cross-sectional…

Methodology · Statistics 2022-01-13 Fei Gao , Marlena S. Bannick

Nonprobability (convenience) samples are increasingly sought to stabilize estimations for one or more population variables of interest that are performed using a randomized survey (reference) sample by increasing the effective sample size.…

The interpretation of sampling data plays a crucial role in policy response to the spread of a disease during an epidemic, such as the COVID-19 epidemic of 2020. However, this is a non-trivial endeavor due to the complexity of real world…

Populations and Evolution · Quantitative Biology 2020-07-30 James D. Brunner , Nicholas Chia

We demonstrate the ability of statistical data assimilation to identify the measurements required for accurate state and parameter estimation in an epidemiological model for the novel coronavirus disease COVID-19. Our context is an effort…

Populations and Evolution · Quantitative Biology 2020-08-04 Eve Armstrong , Manuela Runge , Jaline Gerardin

This paper investigates various ways in which a pandemic such as the novel coronavirus, could be predicted using different mathematical models. It also studies the various ways in which these models could be depicted using various…

General Economics · Economics 2021-02-16 Shailesh Bharati , Rahul Batra