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The inference of gene regulatory networks (GRNs) is a foundational stride towards deciphering the fundamentals of complex biological systems. Inferring a possible regulatory link between two genes can be formulated as a link prediction…

Machine Learning · Computer Science 2025-04-25 Binon Teji , Swarup Roy

Reciprocal best match graphs (RBMGs) are vertex colored graphs whose vertices represent genes and the colors the species where the genes reside. Edges identify pairs of genes that are most closely related with respect to an underlying…

Computational Complexity · Computer Science 2019-07-23 Marc Hellmuth , Manuela Geiß , Peter F. Stadler

A major problem for inferring species trees from gene trees is that evolutionary processes can sometimes favour gene tree topologies that conflict with an underlying species tree. In the case of incomplete lineage sorting, this phenomenon…

Populations and Evolution · Quantitative Biology 2012-12-03 Mike Steel , Simone Linz , Daniel H. Huson , Michael J. Sanderson

2-colored best match graphs (2-BMGs) form a subclass of sink-free bi-transitive graphs that appears in phylogenetic combinatorics. There, 2-BMGs describe evolutionarily most closely related genes between a pair of species. They are…

Populations and Evolution · Quantitative Biology 2021-01-19 David Schaller , Manuela Geiß , Marc Hellmuth , Peter F. Stadler

In phylogenetic studies, the evolution of molecular sequences is assumed to have taken place along the phylogeny traced by the ancestors of extant species. In the presence of lateral gene transfer (LGT), however, this may not be the case,…

Populations and Evolution · Quantitative Biology 2013-07-01 Gergely J Szöllösi , Eric Tannier , Nicolas Lartillot , Vincent Daubin

Synthetic lethality (SL) prediction is used to identify if the co-mutation of two genes results in cell death. The prevalent strategy is to abstract SL prediction as an edge classification task on gene nodes within SL data and achieve it…

Machine Learning · Computer Science 2023-10-18 Xusheng Zhao , Hao Liu , Qiong Dai , Hao Peng , Xu Bai , Huailiang Peng

Multi-graph learning is crucial for extracting meaningful signals from collections of heterogeneous graphs. However, effectively integrating information across graphs with differing topologies, scales, and semantics, often in the absence of…

Machine Learning · Computer Science 2026-02-02 Zahra Moslemi , Ziyi Liang , Norbert Fortin , Babak Shahbaba

On graph data, the multitude of node or edge types gives rise to heterogeneous information networks (HINs). To preserve the heterogeneous semantics on HINs, the rich node/edge types become a cornerstone of HIN representation learning.…

Machine Learning · Computer Science 2023-02-22 Trung-Kien Nguyen , Zemin Liu , Yuan Fang

Horizontal gene transfer inference approaches are usually based on gene sequences: parametric methods search for patterns that deviate from a particular genomic signature, while phylogenetic methods use sequences to reconstruct the gene and…

Discrete Mathematics · Computer Science 2023-12-06 Alitzel López Sánchez , Manuel Lafond

Technology convergence integrates distinct domains to create novel combinations, driving radical innovation that reshapes markets and industries. However, most approaches rely on pairwise networks that cannot capture multi-technology…

Physics and Society · Physics 2026-02-27 Yiwei Huang , Shuqi Xu , Shimin Cai , Linyuan Lü

Graph representation learning (GRL) has emerged as an effective technique for modeling graph-structured data. When modeling heterogeneity and dynamics in real-world complex networks, GRL methods designed for complex heterogeneous temporal…

Social and Information Networks · Computer Science 2026-05-19 Huan Liu , Pengfei Jiao , Mengzhou Gao , Chaochao Chen , Di Jin

Heterogeneous graphs (HGs) also known as heterogeneous information networks have become ubiquitous in real-world scenarios; therefore, HG embedding, which aims to learn representations in a lower-dimension space while preserving the…

Social and Information Networks · Computer Science 2020-12-02 Xiao Wang , Deyu Bo , Chuan Shi , Shaohua Fan , Yanfang Ye , Philip S. Yu

This is the second part of the paper that provides a new strategy for the heterogeneous change detection (HCD) problem, that is, solving HCD from the perspective of graph signal processing (GSP). We construct a graph to represent the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Yuli Sun , Lin Lei , Dongdong Guan , Gangyao Kuang , Li Liu

We introduce a dense counterpart of graph degeneracy, which extends the recently-proposed invariant symmetric difference. We say that a graph has sd-degeneracy (for symmetric-difference degeneracy) at most $d$ if it admits an elimination…

Data Structures and Algorithms · Computer Science 2024-05-16 Édouard Bonnet , Julien Duron , John Sylvester , Viktor Zamaraev

Graph Neural Networks usually rely on the assumption that the graph topology is available to the network as well as optimal for the downstream task. Latent graph inference allows models to dynamically learn the intrinsic graph structure of…

Machine Learning · Computer Science 2023-06-28 Haitz Sáez de Ocáriz Borde , Anees Kazi , Federico Barbero , Pietro Liò

In order to make more complex number-based strings from topological coding for defending against the intelligent attacks equipped with quantum computing and providing effective protection technology for the age of quantum computing, we will…

Cryptography and Security · Computer Science 2024-04-18 Bing Yao , Fei Ma

The complex pattern of presence and absence of many genes across different species provides tantalising clues as to how genes evolved through the processes of gene genesis, gene loss and lateral gene transfer (LGT). The extent of LGT,…

Populations and Evolution · Quantitative Biology 2009-11-09 Leo van Iersel , Charles Semple , Mike Steel

Research shows that gene duplication followed by either repurposing or removal of duplicated genes is an important contributor to evolution of gene and protein interaction networks. We aim to identify which characteristics of a network can…

Molecular Networks · Quantitative Biology 2021-07-27 Peter Crawford-Kahrl , Robert R. Nerem , Bree Cummins , Tomas Gedeon

Learning a hidden hypergraph is a natural generalization of the classical group testing problem that consists in detecting unknown hypergraph $H_{un}=H(V,E)$ by carrying out edge-detecting tests. In the given paper we focus our attention…

Information Theory · Computer Science 2016-11-18 A. G. D'yachkov , I. V. Vorobyev , N. A. Polyanskii , V. Yu. Shchukin

An edge labeling of a graph distinguishes neighbors by sets (multisets, resp.), if for any two adjacent vertices $u$ and $v$ the sets (multisets, resp.) of labels appearing on edges incident to $u$ and $v$ are different. In an analogous way…

Discrete Mathematics · Computer Science 2018-04-30 Karolina Okrasa , Paweł Rzążewski