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We tackle the challenges of modeling high-dimensional data sets, particularly those with latent low-dimensional structures hidden within complex, non-linear, and noisy relationships. Our approach enables a seamless integration of concepts…

Machine Learning · Statistics 2025-03-17 Zichuan Guo , Mihai Cucuringu , Alexander Y. Shestopaloff

Single-cell gene expression data are often characterized by large matrices, where the number of cells may be lower than the number of genes of interest. Factorization models have emerged as powerful tools to condense the available…

Methodology · Statistics 2023-05-22 Antonio Canale , Luisa Galtarossa , Davide Risso , Lorenzo Schiavon , Giovanni Toto

Researchers in the field of ultra-intense laser science are beginning to embrace machine learning methods. In this study we consider three different machine learning methods -- a two-hidden layer neural network, Support Vector Regression…

Convolutional Neural Networks (CNNs), a prominent type of Deep Neural Networks (DNNs), have emerged as a state-of-the-art solution for solving machine learning tasks. To improve the performance and energy efficiency of CNN inference, the…

Hardware Architecture · Computer Science 2024-08-06 Rachmad Vidya Wicaksana Putra , Muhammad Abdullah Hanif , Muhammad Shafique

Detecting and discovering new gene interactions based on known gene expressions and gene interaction data presents a significant challenge. Various statistical and deep learning methods have attempted to tackle this challenge by leveraging…

Machine Learning · Computer Science 2023-10-09 Ahmed Fakhry , Raneem Khafagy , Adriaan-Alexander Ludl

Machine learning methods play increasingly important roles in pre-procedural planning for complex surgeries and interventions. Very often, however, researchers find the historical records of emerging surgical techniques, such as the…

Computer Vision and Pattern Recognition · Computer Science 2019-02-06 Jialei Chen , Yujia Xie , Kan Wang , Zih Huei Wang , Geet Lahoti , Chuck Zhang , Mani A Vannan , Ben Wang , Zhen Qian

With the introduction of the Electric Health Records, large amounts of digital data become available for analysis and decision support. When physicians are prescribing treatments to a patient, they need to consider a large range of data…

Machine Learning · Computer Science 2016-12-05 Yinchong Yang , Peter A. Fasching , Markus Wallwiener , Tanja N. Fehm , Sara Y. Brucker , Volker Tresp

Learning tasks such as those involving genomic data often poses a serious challenge: the number of input features can be orders of magnitude larger than the number of training examples, making it difficult to avoid overfitting, even when…

Manifold learning techniques play a pivotal role in machine learning by revealing lower-dimensional embeddings within high-dimensional data, thus enhancing both the efficiency and interpretability of data analysis by transforming the data…

Neural and Evolutionary Computing · Computer Science 2025-05-02 Ben Cravens , Andrew Lensen , Paula Maddigan , Bing Xue

Feature selection is a dimensionality reduction technique that selects a subset of representative features from high dimensional data by eliminating irrelevant and redundant features. Recently, feature selection combined with sparse…

Computer Vision and Pattern Recognition · Computer Science 2018-04-24 Siwei Feng , Marco F. Duarte

This paper introduces a 3D shape generative model based on deep neural networks. A new image-like (i.e., tensor) data representation for genus-zero 3D shapes is devised. It is based on the observation that complicated shapes can be well…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Heli Ben-Hamu , Haggai Maron , Itay Kezurer , Gal Avineri , Yaron Lipman

Hypergraph neural networks can model multi-way connections among nodes of the graphs, which are common in real-world applications such as genetic medicine. In particular, genetic pathways or gene sets encode molecular functions driven by…

Machine Learning · Computer Science 2022-10-17 Yuan Luo

Reducing parameter redundancies in neural network architectures is crucial for achieving feasible computational and memory requirements during training and inference phases. Given its easy implementation and flexibility, one promising…

Machine Learning · Computer Science 2025-08-22 Emanuele Zangrando , Steffen Schotthöfer , Gianluca Ceruti , Jonas Kusch , Francesco Tudisco

Selecting the right drugs for the right patients is a primary goal of precision medicine. In this manuscript, we consider the problem of cancer drug selection in a learning-to-rank framework. We have formulated the cancer drug selection…

Machine Learning · Computer Science 2025-03-25 Yicheng He , Junfeng Liu , Xia Ning

Safe deployment of AI models requires proactive detection of failures to prevent costly errors. To this end, we study the important problem of detecting failures in deep regression models. Existing approaches rely on epistemic uncertainty…

Machine Learning · Computer Science 2024-06-04 Jayaraman J. Thiagarajan , Vivek Narayanaswamy , Puja Trivedi , Rushil Anirudh

Attentive Neural Process (ANP) improves the fitting ability of Neural Process (NP) and improves its prediction accuracy, but the higher time complexity of the model imposes a limitation on the length of the input sequence. Inspired by…

Computer Vision and Pattern Recognition · Computer Science 2022-02-07 Xiaohan Yu , Shaochen Mao

Accurately predicting gene mutations, mutation subtypes and their exons in lung cancer is critical for personalized treatment planning and prognostic assessment. Faced with regional disparities in medical resources and the high cost of…

Genomics · Quantitative Biology 2025-12-01 Liangrui Pan , Qingchun Liang , Shen Zhao , Songqing Fan , Shaoliang Peng

Recent advances in machine learning (ML) and computer vision tools have enabled applications in a wide variety of arenas such as financial analytics, medical diagnostics, and even within the Department of Defense. However, their widespread…

Computer Vision and Pattern Recognition · Computer Science 2020-08-13 Shashank Manjunath , Aitzaz Nathaniel , Jeff Druce , Stan German

Tensor decompositions, which represent an $N$-order tensor using approximately $N$ factors of much smaller dimensions, can significantly reduce the number of parameters. This is particularly beneficial for high-order tensors, as the number…

Machine Learning · Computer Science 2025-06-23 Zhen Qin , Michael B. Wakin , Zhihui Zhu

While imaging-genetics holds great promise for unraveling the complex interplay between brain structure and genetic variation in neurological disorders, traditional methods are limited to simplistic linear models or to black-box techniques…