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Gene expression data represents a unique challenge in predictive model building, because of the small number of samples $(n)$ compared to the huge amount of features $(p)$. This "$n<<p$" property has hampered application of deep learning…

Machine Learning · Statistics 2018-02-13 Yunchuan Kong , Tianwei Yu

A structural optimization scheme for a single-layer nonnegative adaptive tensor tree (NATT) that models a target probability distribution is proposed as an alternative paradigm for generative modeling. The NATT scheme, by construction,…

Machine Learning · Computer Science 2025-07-02 Katsuya O. Akamatsu , Kenji Harada , Tsuyoshi Okubo , Naoki Kawashima

Cancer is a heterogeneous disease with diverse molecular etiologies and outcomes. The Cancer Genome Atlas (TCGA) has released a large compendium of over 10,000 tumors with RNA-seq gene expression measurements. Gene expression captures the…

Genomics · Quantitative Biology 2017-11-15 Gregory P. Way , Casey S. Greene

The development of self-propelled particles at the micro- and the nanoscale has sparked a huge potential for future applications in active matter physics, microsurgery, and targeted drug delivery. However, while the latter applications…

Soft Condensed Matter · Physics 2022-08-24 Mahdi Nasiri , Benno Liebchen

The tensor-structured parametric analysis (TPA) has been recently developed for simulating and analysing stochastic behaviours of gene regulatory networks [Liao et. al., 2015]. The method employs the Fokker-Planck approximation of the…

Quantitative Methods · Quantitative Biology 2019-10-08 Shuohao Liao

Mapping gene expression as a quantitative trait using whole genome-sequencing and transcriptome analysis allows to discover the functional consequences of genetic variation. We developed a novel method and ultra-fast software Findr for…

Genomics · Quantitative Biology 2017-08-23 Lingfei Wang , Tom Michoel

To achieve autonomous driving without high-definition maps, we present a model capable of generating multiple plausible paths from egocentric images for autonomous vehicles. Our generative model comprises two neural networks: the feature…

Computer Vision and Pattern Recognition · Computer Science 2021-03-04 Dooseop Choi , Seung-jun Han , Kyoungwook Min , Jeongdan Choi

Despite the success of existing tensor factorization methods, most of them conduct a multilinear decomposition, and rarely exploit powerful modeling frameworks, like deep neural networks, to capture a variety of complicated interactions in…

Machine Learning · Computer Science 2020-07-16 Shikai Fang , Zheng Wang , Zhimeng Pan , Ji Liu , Shandian Zhe

Deep neural networks usually benefit from unsupervised pre-training, e.g. auto-encoders. However, the classifier further needs supervised fine-tuning methods for good discrimination. Besides, due to the limits of full-connection, the…

Computer Vision and Pattern Recognition · Computer Science 2016-05-10 Hailin Shi , Xiangyu Zhu , Zhen Lei , Shengcai Liao , Stan Z. Li

Emerging research has highlighted that artificial intelligence-based multimodal fusion of digital pathology and transcriptomic features can improve cancer diagnosis (grading/subtyping) and prognosis (survival risk) prediction. However, such…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Samiran Dey , Christopher R. S. Banerji , Partha Basuchowdhuri , Sanjoy K. Saha , Deepak Parashar , Tapabrata Chakraborti

Density based representations of atomic environments that are invariant under Euclidean symmetries have become a widely used tool in the machine learning of interatomic potentials, broader data-driven atomistic modelling and the…

In medical genetics, each genetic variant is evaluated as an independent entity regarding its clinical importance. However, in most complex diseases, variant combinations in specific gene networks, rather than the presence of a particular…

Machine Learning · Computer Science 2023-01-30 Suha Tuna , Cagri Gulec , Emrah Yucesan , Ayse Cirakoglu , Yelda Tarkan Arguden

We introduce complex-valued tensor network models for sequence processing motivated by correspondence to probabilistic graphical models, interpretability and resource compression. Inductive bias is introduced to our models via network…

Quantum Physics · Physics 2023-08-16 Carys Harvey , Richie Yeung , Konstantinos Meichanetzidis

The recent low-rank prior based models solve the tensor completion problem efficiently. However, these models fail to exploit the local patterns of tensors, which compromises the performance of tensor completion. In this paper, we propose a…

Numerical Analysis · Mathematics 2021-04-13 Liyu Su

Progress in the application of machine learning techniques to the prediction of solid-state and molecular materials properties has been greatly facilitated by the development state-of-the-art feature representations and novel deep learning…

Materials Science · Physics 2022-03-21 David E. Sommer , Scott T. Dunham

Identifying genes associated with complex human diseases is one of the main challenges of human genetics and computational medicine. To answer this question, millions of genetic variants get screened to identify a few of importance. To…

Genomics · Quantitative Biology 2015-09-01 Aziz M. Mezlini , Fabio Fuligni , Adam Shlien , Anna Goldenberg

With the advent of quantum and quantum-inspired machine learning, adapting the structure of learning models to match the structure of target datasets has been shown to be crucial for obtaining high performance. Probabilistic models based on…

Quantum Physics · Physics 2022-11-30 Atithi Acharya , Manuel Rudolph , Jing Chen , Jacob Miller , Alejandro Perdomo-Ortiz

Machine learning methods can detect complex relationships between variables, but usually do not exploit domain knowledge. This is a limitation because in many scientific disciplines, such as systems biology, domain knowledge is available in…

Artificial Intelligence · Computer Science 2023-07-31 Bastian Pfeifer , Hubert Baniecki , Anna Saranti , Przemyslaw Biecek , Andreas Holzinger

In the evolving domains of Machine Learning and Data Analytics, existing dataset characterization methods such as statistical, structural, and model-based analyses often fail to deliver the deep understanding and insights essential for…

Machine Learning · Computer Science 2025-10-17 Matthew D. Merris , Tim Andersen

High-dimensional tensor-valued predictors arise in modern applications, increasingly as learned representations from neural networks. Existing tensor classification methods rely on sparsity or Tucker structures and often lack theoretical…

Machine Learning · Computer Science 2025-12-16 Elynn Chen , Yuefeng Han , Jiayu Li