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Modeling the time evolution of discrete sets of items (e.g., genetic mutations) is a fundamental problem in many biomedical applications. We approach this problem through the lens of continuous-time Markov chains, and show that the…

Machine Learning · Computer Science 2021-07-08 Alkis Gotovos , Rebekka Burkholz , John Quackenbush , Stefanie Jegelka

In this paper, we study consistent and partially exchangeable sequences of Markov chains on a finite state space. We provide a characterisation of the admissible transition rates via a decomposition into individual and coordinated motion of…

We consider Markov chains on general state spaces in stationary random environment which are defined by a random mapping that is contractive up to a bounded perturbation. We prove their convergence to a limiting law, providing convergence…

Probability · Mathematics 2025-12-18 Attila Lovas , Miklós Rásonyi , Lionel Truquet

This simple note lays out a few observations which are well known in many ways but may not have been said in quite this way before. The basic idea is that when comparing two different Markov chains it is useful to couple them is such a way…

Probability · Mathematics 2017-11-16 James E. Johndrow , Jonathan C. Mattingly

We derive a Poisson random field model for population site polymorphisms differences within and between two species that share a relatively recent common ancestor. The model can be either equilibrium or time inhomogeneous. We first consider…

Probability · Mathematics 2010-11-09 Amei Amei , Stanley Sawyer

A challenge for practitioners of Bayesian inference is specifying a model that incorporates multiple relevant, heterogeneous data sets. It may be easier to instead specify distinct submodels for each source of data, then join the submodels…

Methodology · Statistics 2026-03-24 Andrew A. Manderson , Robert J. B. Goudie

We give computable bounds on the rate of convergence of the transition probabilities to the stationary distribution for a certain class of geometrically ergodic Markov chains. Our results are different from earlier estimates of Meyn and…

Probability · Mathematics 2007-05-23 Peter H. Baxendale

We study Markov chains which model genome rearrangements. These models are useful for studying the equilibrium distribution of chromosomal lengths, and are used in methods for estimating genomic distances. The primary Markov chain studied…

Probability · Mathematics 2007-10-25 Nayantara Bhatnagar , Pietro Caputo , Prasad Tetali , Eric Vigoda

This paper introduces a concept of approximate spectral gap to analyze the mixing time of Markov Chain Monte Carlo (MCMC) algorithms for which the usual spectral gap is degenerate or almost degenerate. We use the idea to analyze a class of…

Computation · Statistics 2019-08-26 Yves F. Atchadé

Bayesian inference for phylogenetics is a gold standard for computing distributions of phylogenies. It faces the challenging problem of. moving throughout the high-dimensional space of trees. However, hyperbolic space offers a low…

Populations and Evolution · Quantitative Biology 2023-07-19 Matthew Macaulay , Aaron E. Darling , Mathieu Fourment

We study very simple sorting algorithms based on a probabilistic comparator model. In our model, errors in comparing two elements are due to (1) the energy or effort put in the comparison and (2) the difference between the compared…

Data Structures and Algorithms · Computer Science 2018-05-16 Barbara Geissmann , Paolo Penna

Markov chains for probability distributions related to matrix product states and 1D Hamiltonians are introduced. With appropriate 'inverse temperature' schedules, these chains can be combined into a random approximation scheme for ground…

Strongly Correlated Electrons · Physics 2014-05-14 S. Iblisdir

Full Bayesian computational inference for model determination in undirected graphical models is currently restricted to decomposable graphs, except for problems of very small scale. In this paper we develop new, more efficient methodology…

Computation · Statistics 2012-06-05 Peter J. Green , Alun Thomas

Kingman's coalescent is a widely used process to model sample genealogies in population genetics. Recently there have been studies on the inference of quantities related to the genealogy of additional individuals given a known sample. This…

Probability · Mathematics 2024-02-29 Linglong Yuan

Consider the Aldous Markov chain on the space of rooted binary trees with $n$ labeled leaves in which at each transition a uniform random leaf is deleted and reattached to a uniform random edge. Now, fix $1\le k < n$ and project the leaf…

Probability · Mathematics 2018-02-06 Noah Forman , Soumik Pal , Douglas Rizzolo , Matthias Winkel

The goal of these lectures is to review some mathematical aspects of random tree models used in evolutionary biology to model gene trees or species trees. We start with stochastic models of tree shapes (finite trees without edge lengths),…

Probability · Mathematics 2017-08-30 Amaury Lambert

In this paper, we propose to study a general notion of a down-up Markov chain for multifurcating trees with n labelled leaves. We study in detail down-up chains associated with the $(\alpha, \gamma)$-model of Chen et al. (2009),…

Probability · Mathematics 2020-09-23 Frederik Sørensen

Randomising networks using a naive `accept-all' edge-swap algorithm is generally biased. Building on recent results for nondirected graphs, we construct an ergodic detailed balance Markov chain with non-trivial acceptance probabilities for…

Quantitative Methods · Quantitative Biology 2011-12-21 E. S. Roberts , A. C. C. Coolen

This article provides the first procedure for computing a fully data-dependent interval that traps the mixing time $t_{\text{mix}}$ of a finite reversible ergodic Markov chain at a prescribed confidence level. The interval is computed from…

Machine Learning · Computer Science 2015-11-04 Daniel Hsu , Aryeh Kontorovich , Csaba Szepesvári

We introduce a Markov Chain Monte Carlo algorithm which samples from the space of spanning trees of complete graphs using local rewiring operations only. The probability distribution of graphs of this kind is shown to depend on the…

Discrete Mathematics · Computer Science 2017-11-21 Neal McBride , John Bulava