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Background Seizure severity can change from one seizure to the next within individual people with epilepsy. It is unclear if and how seizure severity is modulated over longer timescales. Characterising seizure severity variability over time…

Background and Objectives: Many biological processes are modulated by rhythms on circadian and multidien timescales. In focal epilepsy, various seizure features, such as spread and duration, can change from one seizure to the next within…

A seizure's electrographic dynamics are characterised by its spatiotemporal evolution, also termed dynamical "pathway" and the time it takes to complete that pathway, which results in the seizure's duration. Both seizure pathways and…

The extent of intra-individual and inter-individual variability is an important factor in determining the statistical, and hence possibly clinical, significance of observed differences in the EEG. This study investigates the changes in…

Neurons and Cognition · Quantitative Biology 2018-01-08 Sacha Jennifer van Albada , Christopher J. Rennie , Peter A. Robinson

Patients with epilepsy can manifest short, sub-clinical epileptic "bursts" in addition to full-blown clinical seizures. We believe the relationship between these two classes of events---something not previously studied…

Machine Learning · Statistics 2014-07-29 Drausin F. Wulsin , Emily B. Fox , Brian Litt

The amount of power in different frequency bands of the electroencephalogram (EEG) carries information about the behavioral state of a subject. Hence, neurologists treating epileptic patients monitor the temporal evolution of the different…

Neurons and Cognition · Quantitative Biology 2020-06-17 Melisa Maidana Capitán , Nuria Cámpora , Claudio Sebastián , Sigvard Silvia Kochen , Inés Samengo

Objective: The circadian rhythm synchronizes physiological and behavioural patterns with the 24-hour light-dark cycle. Disruption to the circadian rhythm is linked to various health conditions, though optimal methods to describe these…

Background: Direct electrical stimulation of the brain through intracranial electrodes is currently used to probe the epileptic brain as part of pre-surgical evaluation, and it is also being considered for therapeutic treatments through…

Neurons and Cognition · Quantitative Biology 2020-11-18 Christoforos A Papasavvas , Gabrielle M Schroeder , Beate Diehl , Gerold Baier , Peter N Taylor , Yujiang Wang

We investigate the nature of the modifications in the temporal dynamics manifested in the high-frequency EEG spectra of the normal human brain in comparison to the diseased brain undergoing epilepsy. For this purpose, the Fourier…

Chaotic Dynamics · Physics 2025-08-19 Jyotiraj Nath , Shreya Banerjee , Bhaswati Singha Deo , Mayukha Pal , Prasanta K. Panigrahi

Electrophysiological brain signals, such as electroencephalography (EEG), exhibit both periodic and aperiodic components, with the latter often modeled as 1/f noise and considered critical to cognitive and neurological processes. Although…

Neurons and Cognition · Quantitative Biology 2025-05-27 Yuhao Sun , Zhiyuan Ma , Xinke Shen , Jinhao Li , Guan Wang , Sen Song

During the last few years, there has been growing interest in the effects induced by individual variability on activation patterns and brain connectivity. The practical implications of individual variability is of basic relevance for both…

Signal Processing · Electrical Eng. & Systems 2020-01-29 Matteo Demuru , Matteo Fraschini

Understanding brain dynamics in epilepsy is critical for establishing rigorous control objectives that enable new therapeutic methods to mitigate seizure occurrence. In multichannel electrocorticography (ECoG) recordings acquired in 21…

Epilepsy is a common, chronic neurological disorder characterized by recurrent seizures caused by sudden bursts of abnormal electrical activity in the brain. Seizures can often be unpredictable, leading to uncertainty and anxiety for people…

Human-Computer Interaction · Computer Science 2026-04-21 Berenika Ewart-James , Matthew Wragg , Nawid Keshtmand , Amberly Brigden , Paul Marshall , Raul Santos-Rodriguez

Electroencephalography (EEG) monitors ---by either intrusive or noninvasive electrodes--- time and frequency variations and spectral content of voltage fluctuations or waves, known as brain rhythms, which in some way uncover activity during…

Neurons and Cognition · Quantitative Biology 2019-03-13 Javier A. Galadí , Joaquín J. Torres , J. Marro

The underlying dynamics for the electroencephalographic (EEG) recordings from humans but especially epilepsy patients are usually not completely known. However, the ictal activity is claimed to be characterized by synchronous oscillations…

Biological Physics · Physics 2010-08-09 Caglar Tuncay

The fluctuation properties of the human electroencephalogram (EEG) time series are studied using detrended fluctuation analysis. For all 128 channels in each of 18 subjects studied, it is found that the standard deviation of the…

Biological Physics · Physics 2009-11-07 Rudolph C. Hwa , Thomas C. Ferree

The use of EEG signal to diagnose several brain abnormalities is well-established in the literature. Particularly, epileptic seizure can be detected using EEG signals and several works were done in this field. The joint time-frequency…

Signal Processing · Electrical Eng. & Systems 2020-01-24 Abdullah Othman , Mohamed A. Deriche

Time irreversibility (temporal asymmetry) is one of fundamental properties that characterize the nonlinearity of complex dynamical processes, and our brain is a typical complex dynamical system manifested with nonlinearity. Two…

Neurons and Cognition · Quantitative Biology 2020-03-10 Yao Wen-po , Yao wen-li , Dai Jia-fei , Wang Jun

Electroencephalography (EEG) underpins neuroscience, clinical neurophysiology, and brain-computer interfaces (BCIs), yet pronounced inter- and intra-subject variability limits reliability, reproducibility, and translation. This systematic…

Neurons and Cognition · Quantitative Biology 2026-02-03 Xuan-The Tran , Thien-Nhan Vo , Son-Tung Vu , Thoa-Thi Tran , Manh-Dat Nguyen , Thomas Do , Chin-Teng Lin

Objective: Identifying abnormalities in interictal intracranial EEG, by comparing patient data to a normative map, has shown promise for the localisation of epileptogenic tissue and prediction of outcome. The approach typically uses short…

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