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Clinical Practice Guidelines (CPGs) for cancer diseases evolve rapidly due to new evidence generated by active research. Currently, CPGs are primarily published in a document format that is ill-suited for managing this developing knowledge.…

Artificial Intelligence · Computer Science 2023-07-21 Pralaypati Ta , Bhumika Gupta , Arihant Jain , Sneha Sree C , Arunima Sarkar , Keerthi Ram , Mohanasankar Sivaprakasam

Clinical practice guidelines (CPGs) encode evidence-based decision logic that clinicians apply by evaluating patient variables, conditional criteria, and recommendation rules. However, existing methods often use CPGs as free-text training…

Artificial Intelligence · Computer Science 2026-05-27 Yuhao Shen , Lang Cao , Simo Du , Yuqing Wang , Juexiao Zhou , Hao Peng , Yue Guo

In the medical domain, several disease treatment procedures have been documented properly as a set of instructions known as Clinical Practice Guidelines (CPGs). CPGs have been developed over the years on the basis of past treatments, and…

Information Retrieval · Computer Science 2023-08-08 Vasudhan Varma Kandula , Pushpak Bhattacharyya

An automated knowledge modeling algorithm for Cancer Clinical Practice Guidelines (CPGs) extracts the knowledge contained in the CPG documents and transforms it into a programmatically interactable, easy-to-update structured model with…

Computation and Language · Computer Science 2024-08-01 Pralaypati Ta , Bhumika Gupta , Arihant Jain , Sneha Sree C , Keerthi Ram , Mohanasankar Sivaprakasam

The updated recommendations on diagnostic procedures and treatment pathways for a medical condition are documented as graphical flows in Clinical Practice Guidelines (CPGs). For effective use of the CPGs in helping medical professionals in…

Computation and Language · Computer Science 2025-01-27 Bhumika Gupta , Pralaypati Ta , Keerthi Ram , Mohanasankar Sivaprakasam

Clinical practice guidelines (CPGs) provide evidence-based recommendations for patient care; however, integrating them into Artificial Intelligence (AI) remains challenging. Previous approaches, such as rule-based systems, face significant…

Artificial Intelligence · Computer Science 2026-01-08 Ruiqi Deng , Geoffrey Martin , Tony Wang , Gongbo Zhang , Yi Liu , Chunhua Weng , Yanshan Wang , Justin F Rousseau , Yifan Peng

Clinical practice guidelines (CPGs) play a pivotal role in ensuring evidence-based decision-making and improving patient outcomes. While Large Language Models (LLMs) are increasingly deployed in healthcare scenarios, it is unclear to which…

Computation and Language · Computer Science 2026-03-27 Andong Tan , Shuyu Dai , Jinglu Wang , Fengtao Zhou , Yan Lu , Xi Wang , Yingcong Chen , Can Yang , Shujie Liu , Hao Chen

This paper advances the state of the art in text understanding of medical guidelines by releasing two new annotated clinical guidelines datasets, and establishing baselines for using machine learning to extract condition-action pairs. In…

Computation and Language · Computer Science 2017-06-23 Hossein Hematialam , Wlodek Zadrozny

Clinical diagnosis requires answers that are accurate, verifiable, and explicitly grounded in official guidelines. While large language models excel at natural language processing, their tendency to hallucinate undermines their utility in…

Artificial Intelligence · Computer Science 2026-05-29 Navapat Nananukul , Mayank Kejriwal

Background Large Language Models (LLMs), enhanced with Clinical Practice Guidelines (CPGs), can significantly improve Clinical Decision Support (CDS). However, methods for incorporating CPGs into LLMs are not well studied. Methods We…

Computation and Language · Computer Science 2024-01-25 David Oniani , Xizhi Wu , Shyam Visweswaran , Sumit Kapoor , Shravan Kooragayalu , Katelyn Polanska , Yanshan Wang

Academic advances of AI models in high-precision domains, like healthcare, need to be made explainable in order to enhance real-world adoption. Our past studies and ongoing interactions indicate that medical experts can use AI systems with…

Clinical reasoning refers to the cognitive process that physicians employ in evaluating and managing patients. This process typically involves suggesting necessary examinations, diagnosing patients' diseases, and deciding on appropriate…

Computation and Language · Computer Science 2024-06-11 Jiageng WU , Xian Wu , Jie Yang

HealthBench, a benchmark designed to measure the capabilities of AI systems for health better (Arora et al., 2025), has advanced medical language model evaluation through physician-crafted dialogues and transparent rubrics. However, its…

Artificial Intelligence · Computer Science 2025-08-04 Fred Mutisya , Shikoh Gitau , Nasubo Ongoma , Keith Mbae , Elizabeth Wamicha

Background Concept extraction, a subdomain of natural language processing (NLP) with a focus on extracting concepts of interest, has been adopted to computationally extract clinical information from text for a wide range of applications…

Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang

Current medical language models, adapted from large language models (LLMs), typically predict ICD code-based diagnosis from electronic health records (EHRs) because these labels are readily available. However, ICD codes do not capture the…

Computation and Language · Computer Science 2025-12-09 Wenhao Li , Hongkuan Zhang , Hongwei Zhang , Zhengxu Li , Zengjie Dong , Yafan Chen , Niranjan Bidargaddi , Hong Liu

Clinical notes containing valuable patient information are written by different health care providers with various scientific levels and writing styles. It might be helpful for clinicians and researchers to understand what information is…

Computation and Language · Computer Science 2023-03-17 Hoda Memarzadeh , Nasser Ghadiri , Matthias Samwald , Maryam Lotfi Shahreza

This research paper outlines the development and implementation of a novel Clinical Decision Support System (CDSS) that integrates AI predictive modeling with medical knowledge bases. It utilizes the quantifiable information elements in lab…

Artificial Intelligence · Computer Science 2026-03-17 Muhammad Hammad Maqsood , Mubashir Sajid , Khubaib Ahmed , Muhammad Usamah Shahid , Muddassar Farooq

Advanced AI technologies are increasingly integrated into clinical domains to advance patient care. The design and development of clinical AI technologies necessitate seamless collaboration between clinical and technical experts. However,…

Human-Computer Interaction · Computer Science 2026-05-05 Bingsheng Yao , Yao Du , Yue Fu , Xuhai Xu , Yanjun Gao , Hong Yu , Dakuo Wang

Large language models have exhibited exceptional performance on various Natural Language Processing (NLP) tasks, leveraging techniques such as the pre-training, and instruction fine-tuning. Despite these advances, their effectiveness in…

Computation and Language · Computer Science 2023-06-19 Guangyu Wang , Guoxing Yang , Zongxin Du , Longjun Fan , Xiaohu Li
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