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Background: Patient recruitment in clinical trials is hindered by complex eligibility criteria and labor-intensive chart reviews. Prior research using text-only models have struggled to address this problem in a reliable and scalable way…

Computation and Language · Computer Science 2025-03-20 Anatole Callies , Quentin Bodinier , Philippe Ravaud , Kourosh Davarpanah

Disentanglement is a runtime property of parallel programs guaranteeing that parallel tasks remain oblivious to each other's allocations. As demonstrated in the MaPLe compiler and run-time system, disentanglement can be exploited for fast…

Programming Languages · Computer Science 2025-12-03 Alexandre Moine , Stephanie Balzer , Alex Xu , Sam Westrick

The extraction of sequence patterns from a collection of functionally linked unlabeled DNA sequences is known as DNA motif discovery, and it is a key task in computational biology. Several deep learning-based techniques have recently been…

Machine Learning · Computer Science 2022-10-03 Wen Wang , Jianzong Wang , Shijing Si , Zhangcheng Huang , Jing Xiao

Standard multiple testing procedures are designed to report a list of discoveries, or suspected false null hypotheses, given the hypotheses' p-values or test scores. Recently there has been a growing interest in enhancing such procedures by…

Methodology · Statistics 2025-10-29 Jack Freestone , William Stafford Noble , Uri Keich

Single-cell RNA-sequencing (scRNA-seq) has become a routinely used technique to quantify the gene expression profile of thousands of single cells simultaneously. Analysis of scRNA-seq data plays an important role in the study of cell states…

Genomics · Quantitative Biology 2022-10-13 Matthew Brendel , Chang Su , Zilong Bai , Hao Zhang , Olivier Elemento , Fei Wang

Extracting information from r\'esum\'es is typically formulated as a two-stage problem, where the document is first segmented into sections and then each section is processed individually to extract the target entities. Instead, we cast the…

Computation and Language · Computer Science 2023-09-14 Federico Retyk , Hermenegildo Fabregat , Juan Aizpuru , Mariana Taglio , Rabih Zbib

Traditional applications of latent class models (LCMs) often focus on scenarios where a set of unobserved classes are well-defined and easily distinguishable. However, in numerous real-world applications, these classes are weakly separated…

Computation · Statistics 2023-09-21 Mengbing Li , Bolin Wu , Briana Stephenson , Zhenke Wu

We target the problem of automatically synthesizing proofs of semantic equivalence between two programs made of sequences of statements. We represent programs using abstract syntax trees (AST), where a given set of semantics-preserving…

Machine Learning · Computer Science 2023-07-11 Steve Kommrusch , Martin Monperrus , Louis-Noël Pouchet

Biclustering has gained interest in gene expression data analysis due to its ability to identify groups of samples that exhibit similar behaviour in specific subsets of genes (or vice versa), in contrast to traditional clustering methods…

Applications · Statistics 2024-12-12 Luis A. Vargas-Mieles , Paul D. W. Kirk , Chris Wallace

Cell type identification from single-cell transcriptomic data is a common goal of single-cell RNA sequencing (scRNAseq) data analysis. Neural networks have been employed to identify cell types from scRNAseq data with high performance.…

Genomics · Quantitative Biology 2020-05-11 Xishuang Dong , Shanta Chowdhury , Uboho Victor , Xiangfang Li , Lijun Qian

Entity Linking (EL) and Relation Extraction (RE) are fundamental tasks in Natural Language Processing, serving as critical components in a wide range of applications. In this paper, we propose ReLiK, a Retriever-Reader architecture for both…

Computation and Language · Computer Science 2025-05-12 Riccardo Orlando , Pere-Lluis Huguet Cabot , Edoardo Barba , Roberto Navigli

We are interested in the comparison of transcript boundaries from cells which originated in different environments. The goal is to assess whether this phenomenon, called differential splicing, is used to modify the transcription of the…

Applications · Statistics 2013-07-12 Alice Cleynen , Stéphane Robin

Using natural language to query visual information is a fundamental need in real-world applications. Text-Image Retrieval (TIR) retrieves a target image from a gallery based on an image-level description, while Referring Expression…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Xiangzhao Hao , Kuan Zhu , Hongyu Guo , Haiyun Guo , Ning Jiang , Quan Lu , Ming Tang , Jinqiao Wang

Large language models (LLMs) suffer from high inference latency due to the auto-regressive decoding process. Speculative decoding accelerates inference by generating multiple draft tokens using a lightweight model and verifying them in…

Machine Learning · Computer Science 2025-05-27 Yixuan Wang , Yijun Liu , Shiyu ji , Yuzhuang Xu , Yang Xu , Qingfu Zhu , Wanxiang Che

Large language models (LLMs) are increasingly used in scientific domains. While they can produce reasoning-like content via methods such as chain-of-thought prompting, these outputs are typically unstructured and informal, obscuring whether…

Artificial Intelligence · Computer Science 2025-11-18 Pengze Li , Jiaqi Liu , Junchi Yu , Lihao Liu , Mingyu Ding , Wanli Ouyang , Shixiang Tang , Xi Chen

Speculative decoding is an effective technique for accelerating large language model inference by drafting multiple tokens in parallel. In practice, its speedup is often bottlenecked by a rigid verification step that strictly enforces the…

Computation and Language · Computer Science 2026-04-10 Ziyi Wang , Siva Rajesh Kasa , Ankith M S , Santhosh Kumar Kasa , Jiaru Zou , Sumit Negi , Ruqi Zhang , Nan Jiang , Qifan Song

Machine learning methods can automate the in silico design of biological sequences, aiming to reduce costs and accelerate medical research. Given the limited access to wet labs, in silico design methods commonly use an oracle model to…

Machine Learning · Computer Science 2025-02-25 Shikha Surana , Nathan Grinsztajn , Timothy Atkinson , Paul Duckworth , Thomas D. Barrett

Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into cellular heterogeneity, enabling detailed analysis of complex biological systems at single-cell resolution. However, the high dimensionality and technical noise…

Genomics · Quantitative Biology 2025-09-04 Hojjat Torabi Goudarzi , Maziyar Baran Pouyan

As high-throughput sequencing has become common practice, the cost of sequencing large amounts of genetic data has been drastically reduced, leading to much larger data sets for analysis. One important task is to identify biological…

Methodology · Statistics 2014-10-14 Ciaran Evans , Johanna Hardin , Mark Huber , Daniel Stoebel , Garrett Wong

High-throughput RNA sequencing (RNA-seq) has emerged as a revolutionary and powerful technology for expression profiling. Most proposed methods for detecting differentially expressed (DE) genes from RNA-seq are based on statistics that…

Genomics · Quantitative Biology 2014-11-18 Li Zhang , Xuejun Liu , Songcan Chen