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In this paper, we study the properties of robust nonparametric estimation using deep neural networks for regression models with heavy tailed error distributions. We establish the non-asymptotic error bounds for a class of robust…

Statistics Theory · Mathematics 2021-07-23 Guohao Shen , Yuling Jiao , Yuanyuan Lin , Jian Huang

Traditional Convolutional Neural Networks (CNNs) typically use the same activation function (usually ReLU) for all neurons with non-linear mapping operations. For example, the deep convolutional architecture Inception-v4 uses ReLU. To…

Computer Vision and Pattern Recognition · Computer Science 2018-05-31 Luna M. Zhang

Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot…

Machine Learning · Computer Science 2019-03-25 Jack Albright

Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…

Quantitative Methods · Quantitative Biology 2021-05-31 Nanyan Zhu , Chen Liu , Xinyang Feng , Dipika Sikka , Sabrina Gjerswold-Selleck , Scott A. Small , Jia Guo

Quantitative characterization of disease progression using longitudinal data can provide long-term predictions for the pathological stages of individuals. This work studies the robust modeling of Alzheimer's disease progression using…

Many biomedical studies have identified important imaging biomarkers that are associated with both repeated clinical measures and a survival outcome. The functional joint model (FJM) framework, proposed in Li and Luo (2017), investigates…

Methodology · Statistics 2021-09-24 Yue Wang , Joseph Ibrahim , Hongtu Zhu

The partial linear Cox model for interval-censoring is well-studied under the additive assumption but is still under-investigated without this assumption. In this paper, we propose to use a deep ReLU neural network to estimate the…

Methodology · Statistics 2023-07-04 Jie Zhou , Yue Zhang , Zhangsheng Yu

We study the approximation capacity of some variation spaces corresponding to shallow ReLU$^k$ neural networks. It is shown that sufficiently smooth functions are contained in these spaces with finite variation norms. For functions with…

Machine Learning · Statistics 2024-06-05 Yunfei Yang , Ding-Xuan Zhou

In this paper, we show how convolutional neural networks (CNN) can be used in regression and classification learning problems of noisy and non-noisy functional data. The main idea is to transform the functional data into a 28 by 28 image.…

Machine Learning · Computer Science 2023-10-09 Jose Galarza , Tamer Oraby

Recently, machine learning techniques especially predictive modeling and pattern recognition in biomedical sciences from drug delivery system to medical imaging has become one of the important methods which are assisting researchers to have…

Computer Vision and Pattern Recognition · Computer Science 2017-05-23 Saman Sarraf , Ghassem Tofighi

In the context of multivariate nonparametric regression with missing covariates, we propose Pattern Embedded Neural Networks (PENNs), which can be applied in conjunction with any existing imputation technique. In addition to a neural…

Methodology · Statistics 2025-04-30 Tianyi Ma , Tengyao Wang , Richard J. Samworth

Over the past few years, there has been a significant amount of research focused on studying the ReLU activation function, with the aim of achieving neural network convergence through over-parametrization. However, recent developments in…

Machine Learning · Computer Science 2023-03-30 Yeqi Gao , Sridhar Mahadevan , Zhao Song

A central topic in functional data analysis is how to design an optimaldecision rule, based on training samples, to classify a data function. We exploit the optimal classification problem when data functions are Gaussian processes. Sharp…

Methodology · Statistics 2021-09-14 Shuoyang Wang , Zuofeng Shang , Guanqun Cao , Jun Liu

Alzheimer's disease detection requires expensive neuroimaging or invasive procedures, limiting accessibility. This study explores whether deep learning can enable non-invasive Alzheimer's disease detection through handwriting analysis.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-19 Emanuele Nardone , Tiziana D'Alessandro , Francesco Fontanella , Claudio De Stefano

We explore the phase diagram of approximation rates for deep neural networks and prove several new theoretical results. In particular, we generalize the existing result on the existence of deep discontinuous phase in ReLU networks to…

Neural and Evolutionary Computing · Computer Science 2021-01-07 Dmitry Yarotsky , Anton Zhevnerchuk

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of…

Computer Vision and Pattern Recognition · Computer Science 2020-08-28 Wonsik Jung , Eunji Jun , Heung-Il Suk

In this paper, we focus on fully connected deep neural networks utilizing the Rectified Linear Unit (ReLU) activation function for nonparametric estimation. We derive non-asymptotic bounds that lead to convergence rates, addressing both…

Data harmonization is the process by which an equivalence is developed between two variables measuring a common trait. Our problem is motivated by dementia research in which multiple tests are used in practice to measure the same underlying…

Methodology · Statistics 2021-10-13 Steven Wilkins-Reeves , Yen-Chi Chen , Kwun Chuen Gary Chan

We introduce a new class of non-linear function-on-function regression models for functional data using neural networks. We propose a framework using a hidden layer consisting of continuous neurons, called a continuous hidden layer, for…

Methodology · Statistics 2023-10-10 Aniruddha Rajendra Rao , Matthew Reimherr

We study the approximation capacity of deep ReLU recurrent neural networks (RNNs) and explore the convergence properties of nonparametric least squares regression using RNNs. We derive upper bounds on the approximation error of RNNs for…

Machine Learning · Statistics 2025-10-07 Yuling Jiao , Yang Wang , Bokai Yan